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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Tyler B. Kratzer MPH Ahmedin Jemal DVM PhD Kimberly D. Miller MPH Sarah Nash PhD Charles Wiggins PhD Diana Redwood PhD Robert Smith PhD Rebecca L. Siegel MPH 《CA: a cancer journal for clinicians》2023,73(2):120-146
American Indian and Alaska Native (AIAN) individuals are diverse culturally and geographically but share a high prevalence of chronic illness, largely because of obstacles to high-quality health care. The authors comprehensively examined cancer incidence and mortality among non-Hispanic AIAN individuals, compared with non-Hispanic White individuals for context, using population-based data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries. Overall cancer rates among AIAN individuals were 2% higher than among White individuals for incidence (2014 through 2018, confined to Purchased/Referred Care Delivery Area counties to reduce racial misclassification) but 18% higher for mortality (2015 through 2019). However, disparities varied widely by cancer type and geographic region. For example, breast and prostate cancer mortality rates are 8% and 31% higher, respectively, in AIAN individuals than in White individuals despite lower incidence and the availability of early detection tests for these cancers. The burden among AIAN individuals is highest for infection-related cancers (liver, stomach, and cervix), for kidney cancer, and for colorectal cancer among indigenous Alaskans (91.3 vs. 35.5 cases per 100,000 for White Alaskans), who have the highest rates in the world. Steep increases for early onset colorectal cancer, from 18.8 cases per 100,000 Native Alaskans aged 20–49 years during 1998 through 2002 to 34.8 cases per 100,000 during 2014 through 2018, exacerbated this disparity. Death rates for infection-related cancers (liver, stomach, and cervix), as well as kidney cancer, were approximately two-fold higher among AIAN individuals compared with White individuals. These findings highlight the need for more effective strategies to reduce the prevalence of chronic oncogenic infections and improve access to high-quality cancer screening and treatment for AIAN individuals. Mitigating the disparate burden will require expanded financial support of tribal health care as well as increased collaboration and engagement with this marginalized population. 相似文献
2.
Carlos Casas-Arozamena Cristian Pablo Moiola Ana Vilar Marta Bouso Juan Cueva Silvia Cabrera Victoria Sampayo Efigenia Arias Alicia Abalo Ángel García Ramón Manuel Lago-Lestón Sara Oltra Eva Díaz Juan Ruiz-Bañobre Rafael López-López Gema Moreno-Bueno Antonio Gil-Moreno Eva Colás Miguel Abal Laura Muinelo-Romay 《International journal of cancer. Journal international du cancer》2023,152(10):2206-2217
The analysis of mismatch repair proteins in solid tissue is the standard of care (SoC) for the microsatellite instability (MSI) characterization in endometrial cancer (EC). Uterine aspirates (UAs) or circulating-DNA (cfDNA) samples capture the intratumor heterogeneity and provide a more comprehensive and dynamic molecular diagnosis. Thus, MSI analysis by droplet-digital PCR (ddPCR) in UAs and cfDNA can provide a reliable tool to characterize and follow-up the disease. The UAs, paraffin-embedded tumor tissue (FFPE) and longitudinal plasma samples from a cohort of 90 EC patients were analyzed using ddPCR panel and compared to the SoC. A high concordance (96.67%) was obtained between the analysis of MSI markers in UAs and the SoC. Three discordant cases were validated as unstable by ddPCR on FFPE samples. Besides, a good overall concordance (70.27%) was obtained when comparing the performance of the ddPCR assay on UAs and cfDNA in high-risk tumors. Importantly, our results also evidenced the value of MSI analysis to monitor the disease evolution. MSI evaluation in minimally invasive samples shows great accuracy and sensitivity and provides a valuable tool for the molecular characterization and follow-up of endometrial tumors, opening new opportunities for personalized management of EC. 相似文献
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Perkins Jessica M. Kakuhikire Bernard Baguma Charles Rasmussen Justin D. Satinsky Emily N. Kiconco Allen Kananura Justus Audet Carolyn M. Siedner Mark J. Haberer Jessica E. Bangsberg David R. Tsai Alexander C. 《AIDS and behavior》2022,26(6):1892-1904
AIDS and Behavior - Although misperceived norms often drive personal health behaviors, we do not know about this phenomenon in the context of antiretroviral therapy (ART) adherence. We conducted a... 相似文献
6.
Spindler L. Alam A. Fathallah N. Rentien A.-L. Draullette M. Pommaret E. Thierry M.-L. Mituialy A. El Abbes L. Aubert M. Benfredj P. Far E. Safa Beaussier H. de Parades V. 《Techniques in coloproctology》2022,26(2):143-146
Techniques in Coloproctology - The aim of our study was to assess the efficacy of sinus laser therapy (SiLaT) for the treatment of pilonidal disease. All adult patients treated with SiLaT in our... 相似文献
7.
Hunter Theresa Grabner Michael Birt Julie Isenberg Keith Shan Mingyang Teng Chia-Chen Wu Jianmin Griffing Kirstin Lisse Jeffrey Curtis Jeffrey R. 《Clinical rheumatology》2022,41(9):2863-2874
Clinical Rheumatology - This study aimed to assess treatment patterns and frequency of inadequate response associated with advanced therapy initiation among patients with ankylosing spondylitis... 相似文献
8.
Espersen Caroline Modin Daniel Hoffmann Søren Hagemann Christoffer A. Hagemann Rikke A. Olsen Flemming J. Fritz-Hansen Thomas Platz Elke Møgelvang Rasmus Biering-Sørensen Tor 《The international journal of cardiovascular imaging》2022,38(1):131-140
The International Journal of Cardiovascular Imaging - Global longitudinal strain (GLS) has proven to be a powerful prognostic marker in various patient populations, but the prognostic value of... 相似文献
9.
Lee Jeesoo El Hangouche Nadia Pathrose Ashitha Soulat Gilles Barker Alex J. Thomas James D. Markl Michael 《The international journal of cardiovascular imaging》2022,38(9):2047-2056
The International Journal of Cardiovascular Imaging - This study investigated the impact of bicuspid aortic valve (BAV) on valve morphology and motion as well as proximal and aortic hemodynamics... 相似文献
10.
Thomas Benjamin R. Gumaer Caitlyn Charlop Marjorie H. 《Journal of developmental and physical disabilities》2022,34(1):113-125
There are few published procedures for teaching athletic skills to children with autism spectrum disorder (ASD). This study used a multiple baseline across participants design to evaluate the effects of prompting, demand fading, and differential reinforcement, on the basketball shooting skills of four school-aged boys diagnosed with ASD. During baseline, all four boys rarely made correct and accurate baskets at the regulation height and distance for their age-group in youth basketball. Following intervention, all four boys increased their percentage of correct shots and accuracy, compared to baseline, and their shooting skills transferred to the game of “P-I-G” with peers.
相似文献