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Medicine, Health Care and Philosophy - Clinical ethics consultants respond to a multitude of issues, ranging from the cognitive to the emotional. As such, ethics consultants must be prepared to... 相似文献
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Ellemarije Altena Clyne H. Bastien Ernesto J. Sanz‐Arigita Yannick Daviaux Stphanie Bioulac Jean‐Arthur Micoulaud‐Franchi Jacques Taillard Pierre Philip 《Journal of sleep research》2020,29(2)
Emotional reactivity in insomnia is affected both subjectively and on a physiological level for negative emotional material, but little is known about reactions to positive stimuli. We here investigated whether in younger adult insomnia patients, presentation of short humorous films would lead to heart rate decreases during and after film viewing, as compared to heart rate changes when falling asleep. Investigating 20 participants with DSM‐5‐diagnosed insomnia and 18 participants without insomnia, we found that heart rate decreased when falling asleep, increased when watching humorous films and returned to normal values afterwards for all participants. Film‐related heart rate increases were strongly related to humour ratings of the films. No differences were found between those with and without insomnia on subjective ratings of the films, film‐related heart rate changes or when falling asleep. We conclude that the experience of positive daily life stimuli in younger adults is not affected by insomnia in our study, despite insomnia having a known more profound effect on negative stimuli. Future studies exploring insomnia‐related autonomous nervous system responses combining different neurophysiological modalities should confirm our findings. 相似文献
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Joubert Bastien Belbezier Aude Haesebaert Julie Rheims Sylvain Ducray François Picard Géraldine Rogemond Véronique Psimaras Dimitri Berzero Giulia Desestret Virginie Honnorat Jérôme 《Journal of neurology》2020,267(7):2083-2089
Journal of Neurology - To assess the long-term outcomes of patients with temporal lobe epilepsy and CSF anti-glutamate decarboxylase antibodies (GAD65-Abs). We retrospectively analyzed the clinical... 相似文献
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Baboudjian Michael Bandelier Quentin Gondran-Tellier Bastien Abdallah Rony Michel Floriane Sichez Pierre Clement Di-Crocco Eugenie Akiki Akram Gaillet Sarah Delaporte Veronique Andre Marc Daniel Laurent Karsenty Gilles Lechevallier Eric Boissier Romain 《International urology and nephrology》2020,52(4):611-618
International Urology and Nephrology - In our center, until 2018, MRI-targeted biopsy was underused. Since January 2018, we systematically performed MRI-targeted biopsy for suspicious... 相似文献
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Romain Dupont Mélanie Longué Anne Galinier Christel Cinq Frais Cécile Ingueneau Léonardo Astudillo Philippe Arlet Daniel Adoue Laurent Alric Grégoire Prévot Bastien Cabarrou Laurent Sailler Grégory Pugnet 《Autoimmunity reviews》2018,17(11):1081-1089
Objectives
The purpose of our study was to determine the prevalence and risk factors associated with malnutrition, and selenium (Se) and vitamin C (vitC) deficiencies in systemic sclerosis (SSc) patients.Methods
We included adult SSc patients fulfilling the 2013 ACR/EULAR criteria from the Toulouse University Hospital cohort who underwent a micronutrient workup (including vitC, Se or thiamine levels) between 2011 and 2016. Results: 82 patients were included, mostly women (76%), with a median age of 60?years. SSc was limited in 76% of the cases, with Scl-70 and centromere antibodies in 32% and 44%, respectively. Median disease duration was 7.4?years. Cardiac involvement was noticed in 19% and gastrointestinal tract in and 95%; 9% had pulmonary artery hypertension (PAH) and 63% had interstitial lung disease. Overt malnutrition was present in 14 (17%) patients. Micronutrient deficiencies included Se (35%), vitC (31%) and/or thiamine (6%). Malnourished patients had significantly a higher summed Medsger disease severity scales (7.5 vs. 5, P?=?.003), lower hemoglobin (10.6 vs. 12.9?g/dL, P?<?.0001) and vitC levels (3.6 vs. 10.6?mg/L, P?=?.003). Cardiac involvement was significantly associated with Se deficiency (OR 6.2, IC 95%[1.48–32.70], P?=?.05). The factors associated with vitC deficiency were malnutrition (OR 8.57, IC 95%[2.16–43.39], P?=?.003), modified Rodnan skin score?≤?14 (OR 0.33, IC95[0.11–1], P?=?.05), PAH (27% in deficient vs. none in non-deficient patients, P?=?.0006) and esophagitis or Barrett's mucosa (OR 4.05, IC95[1.27–13.54], P?=?.02).Conclusions
Se testing should be considered as soon as cardiac involvement is suspected. VitC testing should be considered in malnourished SSc patients, especially if skin involvement is extensive. 相似文献10.
Jean-Michel Constantin Emmanuel Futier Sebastien Perbet Laurence Roszyk Alexandre Lautrette Thierry Gillart Renaud Guerin Matthieu Jabaudon Bertrand Souweine Jean-Etienne Bazin Vincent Sapin 《Journal of critical care》2010