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排序方式: 共有313条查询结果,搜索用时 15 毫秒
1.
M Kleinrok 《The Journal of prosthetic dentistry》1992,68(4):597-606
A recording device termed a "Kleinrok Functiograph" was introduced to simultaneously document condylar- and tooth-guided mandibular movements on the same plate. The Functiograph instrument permitted objective monitoring of mandibular movement without tooth contact, with all tooth contacts, and allowed analysis of the correlation of these two recordings. After 10 years of conducting investigations on centric occlusion using the Functiograph instrument combined with clinical, radiographic, and electromyographic studies, it was possible to differentiate the horizontal Functiograph recordings of normal and disturbed centric occlusion at a clinically acceptable vertical dimension. Two types of centric occlusal disturbances were classified to accelerate diagnosis and standardize communication. 相似文献
2.
Katarzyna Kusnierz Zdzislaw Lekston Dmytro Zhavoronkov Slawomir Mrowiec Pawel Lampe 《The Journal of surgical research》2014
Background
The aim of this study was to evaluate the efficacy of a compression anastomosis clip (CAC) for gastrojejunostomy and comparison of a novel technique with a hand-sewn anastomosis.Methods
Sixty-six patients underwent gastrojejunostomy with the CAC or hand-sewn anastomosis. The time of bowel function recovery, the duration of nasogastric drainage, the time of initiation of oral feeding, the duration of postoperative hospital stay, the time needed to expel the clip, and the observation of any complications were recorded.Results
Neither group had anastomotic complications such as leakage or obstruction. Anastomosis time was shorter in the CAC group than in the control group (P < 0.01). The mean time of clip expulsion was 15.1 ± 6.04 d. There was no statistical difference in postoperative results between the two groups. There was a moderate positive correlation between the day of first bowel movement and the day of clip expulsion (r = 0.536) and a strong correlation between the duration of nasogastric drainage and the day of clip expulsion (r = 0.881).Conclusions
The method of using a CAC appeared to be safe, easy, inexpensive, and less time consuming. It should be taken into consideration that intra-abdominal complications may cause delayed CAC expulsion. 相似文献3.
Limited accuracy of transurethral and periurethral intrasphincteric injections of cellular suspension 下载免费PDF全文
4.
Senkal CE Ponnusamy S Rossi MJ Sundararaj K Szulc Z Bielawski J Bielawska A Meyer M Cobanoglu B Koybasi S Sinha D Day TA Obeid LM Hannun YA Ogretmen B 《The Journal of pharmacology and experimental therapeutics》2006,317(3):1188-1199
In this study, a cationic water-soluble ceramide analog L-threo-C6-pyridinium-ceramide-bromide (L-t-C6-Pyr-Cer), which exhibits high solubility and bioavailability, inhibited the growth of various human head and neck squamous cell carcinoma (HNSCC) cell lines at low IC50 concentrations, independent of their p53 status. Consistent with its design to target negatively charged intracellular compartments, L-t-C6-Pyr-Cer accumulated mainly in mitochondria-, and nuclei-enriched fractions upon treatment of human UM-SCC-22A cells [human squamous cell carcinoma (SCC) of the hypopharynx] at 1 to 6 h. In addition to its growth-inhibitory function as a single agent, the supra-additive interaction of L-t-C6-Pyr-Cer with gemcitabine (GMZ), a chemotherapeutic agent used in HNSCC, was determined using isobologram studies. Then, the effects of this ceramide, alone or in combination with GMZ, on the growth of UM-SCC-22A xenografts in SCID mice was assessed following the determination of preclinical parameters, such as maximum tolerated dose, clearance from the blood, and bioaccumulation. Results demonstrated that treatment with L-t-C6-Pyr-Cer in combination with GMZ significantly prevented the growth of HNSCC tumors in vivo. The therapeutic efficacy of L-t-C6-Pyr-Cer/GMZ combination against HNSCC tumors was approximately 2.5-fold better than that of the combination of 5-fluorouracil/cis-platin. In addition, liquid chromatography/mass spectroscopy analysis showed that the levels of L-t-C6-Pyr-Cer in HNSCC tumors were significantly higher than its levels in the liver and intestines; interestingly, the combination with GMZ increased the sustained accumulation of this ceramide by approximately 40%. Moreover, treatment with L-t-C6-Pyr-Cer/GMZ combination resulted in a significant inhibition of telomerase activity and decrease in telomere length in vivo, which are among downstream targets of ceramide. 相似文献
5.
6.
The ultrastructure of the uterine epithelium and underlying extracellular matrices has been studied in several cyclophyllideans,
but relatively little has been published on uterine fine structure in other cestode orders. To develop comparative data, we
initiated a study focusing on a common and widespread genus of the order Proteocephalidea. Adult specimens of Corallobothrium fimbriatum were removed from the small intestine of brown bullhead catfish, Ameiurus nebulosus, from the St. Lawrence River in North America. Early gravid proglottids were examined by light microscopy as whole mounts
or diced in buffered glutaraldehyde, processed by standard techniques and examined by as stained sections by light microscopy
and by transmission electron microscopy. Voucher specimens were deposited in the Museum of Comparative Zoology at Harvard
University. The uterus consisted of an epithelial wall supported basally by an extracellular matrix and parenchyma cells,
which together formed epitheliomesenchymal villi at many points. The uterine epithelium consisted of a single thin syncytial
layer, folded distally into long epithelial villi that protruded into the lumen at some points. The epithelium’s numerous
nuclei were very close to the lumen, but bulged along with the perinuclear cytoplasm proximally into the surrounding medullary
parenchyma. Each nucleus contained small amounts of evenly dispersed heterochromatin and euchromatin, with a central nucleolus.
Numerous mitochondria occurred in the cytoplasm, which was densely filled with free ribosomes but contained scant endomembrane
components and showed little evidence of secretory activity. The uterine cells possessed few of the apical microvilli that
are typical of some cyclophyllidean species, but the apical plasma membrane and cortical cytoplasm were extensively developed
into long microlamellae similar to other species. The basic syncytial nature of the epithelium is similar to that of other
cestodes studied previously, but the specific combination of features is unlike any previously described. Based on this one
proteocephalidean species, we discerned no pattern that would distinguish between Proteocephalidea and Cyclophyllidea based
on uterine structure. 相似文献
7.
Privatdozent Zdzislaw Sowiński 《Archives of dermatological research》1908,91(2-3):303-326
Ohne Zusammenfassung 相似文献
8.
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents 总被引:5,自引:0,他引:5
Common antiepileptic drugs and agents affecting different neurotransmitter systems were studied against aminophylline (280 mg/kg i.p.)-induced convulsions in mice. All drugs and agents were administered i.p. Diazepam and phenobarbital antagonized the whole seizure pattern and the respective ED50 values for the clonic phase were 3.5 and 62 mg/kg. Valproate at 500 mg/kg protected fewer than 50% of mice against the clonic phase. The remaining antiepileptics (acetazolamide, up to 1,000 mg/kg; carbamazepine and diphenylhydantoin, up to 50 mg/kg; ethosuximide, 500 mg/kg and trimethadione, 400 mg/kg) were totally ineffective in this respect. Propranolol (up to 20 mg/kg), baclofen (20 mg/kg), gamma-hydroxybutyric acid (300 mg/kg), aminooxyacetic acid (20 mg/kg), clonidine (up to 0.2 mg/kg), ketamine (30 mg/kg), atropine (20 mg/kg), papaverine (50 mg/kg) and L-phenylisopropyladenosine (2 mg/kg) did not affect the clonic phase either. Only antagonists of N-methyl-D-aspartic acid excitation, 2-amino-5-phosphonopentanoic acid and 2-amino-7-phosphonoheptanoic acid afforded protection against aminophylline-induced clonic seizure activity. The results show that aminophylline convulsions are relatively resistant to antiepileptic drugs and suggest that antagonists of excitatory transmission are potential antiaminophylline drugs. 相似文献
9.
10.
Effect of Aminophylline on the Protective Action of Common Antiepileptic Drugs Against Electroconvulsions in Mice 总被引:5,自引:4,他引:1
Stanislaw J. Czuczwar Chrysanthy Ikonomidou Zdzisiaw Kleinrok Lechoslaw Turski Waldemar Turski 《Epilepsia》1986,27(3):204-208
The increasing amount of data tends to suggest that adenosine-mediated inhibition may play a role in the anticonvulsant activity of a number of antiepileptic drugs. Consequently, we tried to reverse the protective action of acetazolamide [(40 and 80 mg/kg) i.p.; 60 min before the test]; carbamazepine (20 and 30 mg/kg i.p., 60 min); diazepam (5 and 10 mg/kg i.p., 60 min); diphenylhydantoin (8 and 12 mg/kg i.p., 120 min), phenobarbital (20 and 30 mg/kg i.p., 120 min) and valproate (200 and 300 mg/kg i.p., 30 min) with aminophylline (50 and 100 mg/kg i.p., 30 min) against electroconvulsions in mice. Aminophylline markedly decreased the anticonvulsant efficacy of almost all drugs studied, acetazolamide (40 and 80 mg/kg) and carbamazepine (30 mg/kg) being the only exceptions. The ethylenediamine component of aminophylline did not modify the anticonvulsant activity at all. These results seem to support the suggestion that aminophylline-induced blockade of adenosine receptors might be involved in the reversal of the protective action of at least some drugs studied. Regardless of the nature of the aminophylline-induced impairment in the anticonvulsant efficacy of a number of antiepileptic drugs, the use of methylxanthines in epileptic patients for the treatment of obstructive lung diseases should be avoided. 相似文献