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排序方式: 共有1353条查询结果,搜索用时 15 毫秒
1.
Yoshida Akihito Motomura Kazuya Natsume Atsushi Chalise Lushun Iijima Kentaro Hara Daisuke Kadono Izumi Wakai Kenji Wakabayashi Toshihiko 《Journal of neuro-oncology》2020,146(1):195-205
Journal of Neuro-Oncology - This study aimed to investigate the preoperative predictive factors affecting return to work in patients with gliomas in the left cerebral hemisphere undergoing awake... 相似文献
2.
A possible contribution of endothelial CCN1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis 下载免费PDF全文
3.
ObjectivesTo determine the incidence of prolonged febrile seizures and status epilepticus in the first three years of life.MethodsA questionnaire was sent to 1560 families between April 2016 and March 2017 before their child attended a routine health check at three years of age in Izumo, Shimane prefecture, Japan. The questionnaire included an overview of febrile seizures, including the age at which febrile seizures occurred, the duration, and how the condition was managed.ResultsWe received 1089 (69.8%) responses and these showed that 134 (12.3%) children had a history of febrile seizures. Fourteen children with febrile seizures (10.4%) had prolonged seizures lasting 10–30 min and six children (4.5%) had status epilepticus. Ongoing febrile seizures that did not terminate on arrival to the hospital were observed in 11 children (8.2%) with febrile seizures. The incidence rates of status epilepticus, prolonged febrile seizures including status epilepticus and ongoing febrile seizures were 184, 612 and 337 per 100,000 children aged 36 months or less, respectively.ConclusionsThere was a greater incidence of status epilepticus than previously thought, possibly due to the high prevalence of febrile seizures in Japan. Eight percent of children with febrile seizures were seizing on arrival to the hospital. These ongoing seizures requiring emergency interventions were almost twice more than status epilepticus. Thus, it is necessary to develop an early intervention for the termination of prolonged febrile seizures. 相似文献
4.
Manabu Fujimoto Jun Asai Yoshihide Asano Takayuki Ishii Yohei Iwata Tamihiro Kawakami Masanari Kodera Masatoshi Abe Masahiro Amano Ryuta Ikegami Taiki Isei Zenzo Isogai Takaaki Ito Yuji Inoue Ryokichi Irisawa Masaki Ohtsuka Yoichi Omoto Hiroshi Kato Takafumi Kadono Sakae Kaneko Hiroyuki Kanoh Masakazu Kawaguchi Ryuichi Kukino Takeshi Kono Monji Koga Keisuke Sakai Eiichi Sakurai Yasuko Sarayama Yoichi Shintani Miki Tanioka Hideaki Tanizaki Jun Tsujita Naotaka Doi Takeshi Nakanishi Akira Hashimoto Minoru Hasegawa Masahiro Hayashi Kuninori Hirosaki Hideki Fujita Hiroshi Fujiwara Takeo Maekawa Koma Matsuo Naoki Madokoro Sei-Ichiro Motegi Hiroshi Yatsushiro Osamu Yamasaki Yuichiro Yoshino Andres James LE Pavoux Takao Tachibana Hironobu Ihn Japanese Dermatological Association Guidelines 《The Journal of dermatology》2020,47(10):1071-1109
The Japanese Dermatological Association prepared guidelines focused on the treatment of skin ulcers associated with connective tissue disease/vasculitis practical in clinical settings of dermatological care. Skin ulcers associated with connective tissue diseases or vasculitis occur on the background of a wide variety of diseases including, typically, systemic sclerosis but also systemic lupus erythematosus (SLE), dermatomyositis, rheumatoid arthritis (RA), various vasculitides and antiphospholipid antibody syndrome (APS). Therefore, in preparing the present guidelines, we considered diagnostic/therapeutic approaches appropriate for each of these disorders to be necessary and developed algorithms and clinical questions for systemic sclerosis, SLE, dermatomyositis, RA, vasculitis and APS. 相似文献
5.
Yuzo Nagai Sinsuke Kazama Daisuke Yamada Takuya Miyagawa Koji Murono Koji Yasuda Takeshi Nishikawa Toshiaki Tanaka Tomomichi Kiyomatsu Keisuke Hata Kazushige Kawai Yuri Masui Hiroaki Nozawa Hironori Yamaguchi Soichiro Ishihara Takafumi Kadono Toshiaki Watanabe 《ANNALS OF DERMATOLOGY》2016,28(5):624-628
Treatment of perianal and vulvar extramammary Paget disease (EMPD), rare intraepithelial malignancies, is often challenging because of its potential to spread into the anal canal. However, there is still no consensus regarding the optimal resection margin within the anal canal. Between 2004 and 2014, six patients (three with perianal EMPD and three with vulvar EMPD) in which the spread of Paget cells into the anal canal was highly suspected were referred to our department. To evaluate the disease extent within the anal canal, preoperative mapping biopsy of the anal canal was performed in five out of six patients. Two patients were positive for Paget cells within the anal canal (one at the dentate line and the other at 0.5 cm above the dentate line), whereas in three patients, Paget cell were present only in the skin of the anal verge. Using 1 cm margin within the anal canal from the positive biopsy sites, we performed anal-preserving wide local excision (WLE), and negative resection margins within the anal canal were confirmed in all five patients. The remaining one patient with perianal EMPD did not undergo mapping biopsy of the anal canal because preoperative colonoscopy revealed that the Paget cells had spread into the lower rectum. Therefore, WLE with abdominoperineal resection was performed. During the median follow-up period of 37.3 months, no local recurrence was observed in all patients. Our small case series suggest the usefulness of mapping biopsy of the anal canal for the treatment of perianal and vulvar EMPD. 相似文献
6.
Koji Yoshino Yasuhiro Fujisawa Yoshio Kiyohara Takafumi Kadono Yozo Murata Hisashi Uhara Naohito Hatta Hiroshi Uchi Shigeto Matsushita Tatsuya Takenouchi Toshihiko Hayashi Kuniaki Ohara 《The Journal of dermatology》2016,43(6):633-637
In invasive extramammary Paget's disease (EMPD), distant metastases may develop and the condition may become fatal; however, no standardized treatment has been established. Although based on only a few cases, several chemotherapy regimens were reported to be promising. We conducted a multicenter, retrospective study to evaluate the efficacy of docetaxel for metastatic EMPD. We retrospectively collected data on 18 metastatic EMPD patients treated using docetaxel from 1998 to 2012 in 12 institutes in Japan. The following clinical data were collected: tumor response, time to progression, overall survival and adverse effects. Of those, three patients treated combined with S‐1, one patient treated with weekly schedule and one patient treated combined with radiotherapy were excluded from the further analysis. All 13 patients received monthly docetaxel as the first‐line treatment. The average number of treatment cycles was 9.1. Among the 12 patients with a confirmed response, seven (58%) showed a partial response, three (25%) stable disease and two (17%) progressive disease. The disease control rate (partial response + stable disease) was as high as 83%. The time to progression and median overall survival were 7.1 and 16.6 months, respectively. The 1‐year overall survival rate determined by the Kaplan–Meier method was 75.0%. All adverse effects were manageable and no treatment‐related deaths were observed. The high disease control rate and overall survival shown by this study suggest that first‐line use of docetaxel may be a promising treatment for metastatic EMPD. A prospective clinical trial is required to confirm our results. 相似文献
7.
The wound/burn guidelines – 2: Guidelines for the diagnosis and treatment for pressure ulcers 下载免费PDF全文
Takao Tachibana Shinichi Imafuku Ryokichi Irisawa Masaki Ohtsuka Takafumi Kadono Hiroshi Fujiwara Yoshihide Asano Masatoshi Abe Takayuki Ishii Taiki Isei Takaaki Ito Yuji Inoue Mikio Ohtsuka Fumihide Ogawa Masanari Kodera Tamihiro Kawakami Masakazu Kawaguchi Ryuichi Kukino Takeshi Kono Keisuke Sakai Masakazu Takahara Miki Tanioka Takeshi Nakanishi Yasuhiro Nakamura Akira Hashimoto Minoru Hasegawa Masahiro Hayashi Manabu Fujimoto Takeo Maekawa Koma Matsuo Naoki Madokoro Osamu Yamasaki Yuichiro Yoshino Andres Le Pavoux Hironobu Ihn The Wound/Burn Guidelines Committee 《The Journal of dermatology》2016,43(5):469-506
The Wound/Burn Guidelines Committee consists of members commissioned by the Board of Directors of the Japanese Dermatological Association (JDA). It held several meetings and evaluations in writing since October 2008, and drafted five guidelines for the diagnosis and treatment including commentaries on wounds in general and the Guidelines for the Diagnosis and Treatment for Pressure Ulcers by taking opinions of the Scientific Committee and Board of Directors of JDA into consideration. 相似文献
8.
The wound/burn guidelines – 3: Guidelines for the diagnosis and treatment for diabetic ulcer/gangrene 下载免费PDF全文
Taiki Isei Masatoshi Abe Takeshi Nakanishi Koma Matsuo Osamu Yamasaki Yoshihide Asano Takayuki Ishii Takaaki Ito Yuji Inoue Shinichi Imafuku Ryokichi Irisawa Masaki Ohtsuka Mikio Ohtsuka Fumihide Ogawa Takafumi Kadono Masanari Kodera Tamihiro Kawakami Masakazu Kawaguchi Ryuichi Kukino Takeshi Kono Keisuke Sakai Masakazu Takahara Miki Tanioka Yasuhiro Nakamura Akira Hashimoto Minoru Hasegawa Masahiro Hayashi Manabu Fujimoto Hiroshi Fujiwara Takeo Maekawa Naoki Madokoro Yuichiro Yoshino Andres Le Pavoux Takao Tachibana Hironobu Ihn The Wound/Burn Guidelines Committee 《The Journal of dermatology》2016,43(6):591-619
We aimed to prepare guidelines for the management of diabetic ulcer/gangrene with emphasis on the diagnosis and treatment of skin symptoms. They serve as a tool to improve the quality of the diagnosis and treatment in each patient and, further, to improve the level of the care for diabetic ulcer in Japan by systematically presenting evidence‐based recommendations for clinical judgments by incorporating various viewpoints. 相似文献
9.
Yuichiro Yoshino Mikio Ohtsuka Masakazu Kawaguchi Keisuke Sakai Akira Hashimoto Masahiro Hayashi Naoki Madokoro Yoshihide Asano Masatoshi Abe Takayuki Ishii Taiki Isei Takaaki Ito Yuji Inoue Shinichi Imafuku Ryokichi Irisawa Masaki Ohtsuka Fumihide Ogawa Takafumi Kadono Tamihiro Kawakami Ryuichi Kukino Takeshi Kono Masanari Kodera Masakazu Takahara Miki Tanioka Takeshi Nakanishi Yasuhiro Nakamura Minoru Hasegawa Manabu Fujimoto Hiroshi Fujiwara Takeo Maekawa Koma Matsuo Osamu Yamasaki Andres Le Pavoux Takao Tachibana Hironobu Ihn The Wound/Burn Guidelines Committee 《The Journal of dermatology》2016,43(9):989-1010
Burns are a common type of skin injury encountered at all levels of medical facilities from private clinics to core hospitals. Minor burns heal by topical treatment alone, but moderate to severe burns require systemic management, and skin grafting is often necessary also for topical treatment. Inappropriate initial treatment or delay of initial treatment may exert adverse effects on the subsequent treatment and course. Therefore, accurate evaluation of the severity and initiation of appropriate treatment are necessary. The Guidelines for the Management of Burn Injuries were issued in March 2009 from the Japanese Society for Burn Injuries as guidelines concerning burns, but they were focused on the treatment for extensive and severe burns in the acute period. Therefore, we prepared guidelines intended to support the appropriate diagnosis and initial treatment for patients with burns that are commonly encountered including minor as well as moderate and severe cases. Because of this intention of the present guidelines, there is no recommendation of individual surgical procedures. 相似文献
10.
The relationship between prostate‐specific antigen and TNM classification or Gleason score in prostate cancer patients with low prostate‐specific antigen levels 下载免费PDF全文