全文获取类型
收费全文 | 5772篇 |
免费 | 249篇 |
国内免费 | 53篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 161篇 |
妇产科学 | 156篇 |
基础医学 | 722篇 |
口腔科学 | 166篇 |
临床医学 | 340篇 |
内科学 | 1527篇 |
皮肤病学 | 134篇 |
神经病学 | 294篇 |
特种医学 | 226篇 |
外科学 | 1044篇 |
综合类 | 37篇 |
一般理论 | 1篇 |
预防医学 | 162篇 |
眼科学 | 47篇 |
药学 | 442篇 |
中国医学 | 63篇 |
肿瘤学 | 529篇 |
出版年
2023年 | 30篇 |
2022年 | 18篇 |
2021年 | 113篇 |
2020年 | 65篇 |
2019年 | 93篇 |
2018年 | 110篇 |
2017年 | 79篇 |
2016年 | 124篇 |
2015年 | 121篇 |
2014年 | 163篇 |
2013年 | 200篇 |
2012年 | 333篇 |
2011年 | 317篇 |
2010年 | 225篇 |
2009年 | 190篇 |
2008年 | 358篇 |
2007年 | 382篇 |
2006年 | 349篇 |
2005年 | 358篇 |
2004年 | 347篇 |
2003年 | 403篇 |
2002年 | 434篇 |
2001年 | 95篇 |
2000年 | 69篇 |
1999年 | 101篇 |
1998年 | 100篇 |
1997年 | 68篇 |
1996年 | 54篇 |
1995年 | 52篇 |
1994年 | 57篇 |
1993年 | 63篇 |
1992年 | 39篇 |
1991年 | 39篇 |
1990年 | 61篇 |
1989年 | 43篇 |
1988年 | 43篇 |
1987年 | 53篇 |
1986年 | 58篇 |
1985年 | 35篇 |
1984年 | 29篇 |
1983年 | 30篇 |
1982年 | 24篇 |
1981年 | 22篇 |
1980年 | 17篇 |
1979年 | 12篇 |
1978年 | 18篇 |
1977年 | 11篇 |
1976年 | 10篇 |
1974年 | 8篇 |
1972年 | 9篇 |
排序方式: 共有6074条查询结果,搜索用时 31 毫秒
1.
Takehiko Mori Souichi Shiratori Junji Suzumiya Mineo Kurokawa Motohiro Shindo Uchida Naoyuki Takenaka Katsuto Toshihiro Miyamoto Satoshi Morishige Makoto Hirokawa Takahiro Fukuda Yoshiko Atsuta Ritsuro Suzuki 《Hematological oncology》2020,38(3):266-271
Although allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to provide prolonged remission of relapsed/refractory mycosis fungoides (MF) and Sézary syndrome (SS), its role has not been fully evaluated. Here, the outcomes of allogeneic HSCT for patients with MF/SS were retrospectively evaluated by using the registry database of the Japan Society for Hematopoietic Cell Transplantation. Forty-eight patients were evaluable and enrolled in the analysis. Median age was 45.5 years. Eighteen patients (38%) received myeloablative conditioning, and 33 (69%) received HSCT from an alternative donor. Disease status was complete or partial response in 25% of the patients and relapsed or refractory in the others. At the time of analysis, 18 patients were alive, with a median follow-up of 31.0 months (range, 3.8-31.1). Three-year overall survival (OS) and progression-free survival (PFS) were 30% (95%CI, 16-45%) and 19% (95%CI, 9-31%), respectively. Disease progression was not observed later than 17 months after transplantation. Both disease status and performance status at transplant significantly affected OS and PFS. Although our findings suggest that allogeneic HSCT provides long-term PFS in patients with MF/SS, the timing of transplantation should be decided carefully based on the disease status and the patient's condition in order to improve the outcome. 相似文献
2.
3.
Yasushi Sawayama Hidehiro Itonaga Takuya Fukushima Nobuaki Nakano Hiroshi Fujiwara Atae Utsunomiya Takahiro Fukuda Toshihiro Miyamoto Tetsuya Eto Kaname Miyashita Hirohisa Nakamae Masao Ogata Atsushi Yamanoha Yasuhiko Miyazaki Junya Kanda Yoshiko Atsuta Koji Kato ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation 《American journal of hematology》2019,94(5):E143-E146
4.
Yasushi Yamasaki Keita Harada Shumpei Yamamoto Eriko Yasutomi Shotaro Okanoue Mami Hirai Shohei Oka Yuka Obayashi Hiroyuki Sakae Kenta Hamada Toshihiro Inokuchi Hideaki Kinugasa Yuusaku Sugihara Masahiro Takahara Takehiro Tanaka Sakiko Hiraoka Yoshiro Kawahara Hiroyuki Okada 《Digestive endoscopy》2020,32(5):791-800
5.
6.
Takashi Yorifuji Yoko Kado Midory Higa Diez Toshihiro Kishikawa Satoshi Sanada 《Archives of environmental & occupational health》2016,71(3):170-177
In the 1950s, large-scale food poisoning caused by methylmercury was identified in Minamata, Japan. Although severe intrauterine exposure cases (ie, congenital Minamata disease patients) are well known, possible impacts of methylmercury exposure in utero among residents, which is likely at lower levels than in congenital Minamata disease patients, are rarely explored. In 2014, the authors examined neurological and neurocognitive functions among 18 exposed participants in Minamata, focusing on fine motor, visuospatial construction, and executive functions. More than half of the participants had some fine motor and coordination difficulties. In addition, several participants had lower performance for neurocognitive function tests (the Rey-Osterrieth Complex Figure test and Keio version of the Wisconsin card sorting test). These deficits imply diffuse brain damage. This study suggests possible neurological and neurocognitive impacts of prenatal exposure to methylmercury among exposed residents of Minamata. 相似文献
7.
8.
Intralymphatic histiocytosis comprises M2 macrophages in superficial dermal lymphatics with or without smooth muscles 下载免费PDF全文
Noriki Fujimoto Gen Nakanishi Toshiaki Manabe Taku Fujimura Toshihiro Tanaka 《Journal of cutaneous pathology》2016,43(10):898-902
Intralymphatic histiocytosis represents a rare reactive disorder, which is characterized by the accumulation of macrophages within lymphatic vessels and observed predominantly in upper extremities. The infiltration and preferential M2 differentiation of macrophage are observed in chronic lymphedema, and lymphedema is considered a causative factor of intralymphatic histiocytosis. However, what causes accumulation of histiocytes in the lymphatic vessels remains unclear, and investigation regarding the characteristics of the macrophages has not been evaluated. We present a case of intralymphatic histiocytosis, in which immunohistochemical staining for both macrophages and lymphatic vessels was performed to evaluate the nature of macrophages within lymphatic vessels and to determine the causative factor. Aggregated macrophages were shown to be M2 macrophages positive for CD68, CD163 and CD206 but negative for inducible nitric oxide synthase. Thick lymphatic vessels positive for D2‐40 and α‐SMA in the superficial dermis were observed. We speculate that chronic lymphedema leads to hypertrophy of lymphatic vessels with smooth muscle in the superficial dermis, which may be a kind of malformation, and these lymphatic vessels produce some chemokines that induce intralymphatic aggregation of macrophages. 相似文献
9.
Toshihiro Fukui Shuichiro Takanashi 《Annals of thoracic and cardiovascular surgery》2015,21(3):261-267
Purpose: Early and long-term outcomes of coronary artery bypass grafting (CABG) in patients with left main disease (LMD) with acute coronary syndrome (ACS) have never been assessed.Methods: Between September 2004 and April 2012, 459 patients with LMD underwent first-time isolated CABG. Of those, 191 patients had ACS and 268 did not. Early and late postoperative outcomes were compared between two groups.Results: Patients in the LMD+ACS group were older and more likely to be female. Left ventricular ejection fraction was lower in the LMD+ACS group. In both groups, bilateral internal thoracic artery grafts were used in over 90% of patients and off-pump technique in over 95%. Operative death rate was not significantly different between the groups (LMD+ACS: 2.1% vs. LMD–ACS: 0.4%). Log-rank test revealed that the actuarial survival rate (79.2 ± 3.7% vs. 81.5 ± 3.5%) and freedom from major adverse cardiac and cerebrovascular events (MACCE) (69.2 ± 4.2% vs. 67.0 ± 4.1%) were similar between groups at 7 years. Multivariate analyses demonstrated that ACS was not identified as an independent predictor of operative death, late mortality, and late MACCE.Conclusion: ACS did not have a negative impact on early and late outcomes of CABG in patients with LMD. 相似文献