全文获取类型
收费全文 | 5131篇 |
免费 | 303篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 92篇 |
妇产科学 | 285篇 |
基础医学 | 550篇 |
口腔科学 | 91篇 |
临床医学 | 509篇 |
内科学 | 1132篇 |
皮肤病学 | 59篇 |
神经病学 | 396篇 |
特种医学 | 131篇 |
外科学 | 660篇 |
综合类 | 96篇 |
一般理论 | 2篇 |
预防医学 | 231篇 |
眼科学 | 294篇 |
药学 | 431篇 |
中国医学 | 29篇 |
肿瘤学 | 445篇 |
出版年
2023年 | 16篇 |
2022年 | 24篇 |
2021年 | 99篇 |
2020年 | 53篇 |
2019年 | 111篇 |
2018年 | 153篇 |
2017年 | 99篇 |
2016年 | 114篇 |
2015年 | 157篇 |
2014年 | 197篇 |
2013年 | 247篇 |
2012年 | 404篇 |
2011年 | 373篇 |
2010年 | 285篇 |
2009年 | 210篇 |
2008年 | 304篇 |
2007年 | 318篇 |
2006年 | 315篇 |
2005年 | 273篇 |
2004年 | 238篇 |
2003年 | 202篇 |
2002年 | 175篇 |
2001年 | 164篇 |
2000年 | 157篇 |
1999年 | 129篇 |
1998年 | 21篇 |
1997年 | 31篇 |
1996年 | 22篇 |
1995年 | 23篇 |
1994年 | 25篇 |
1993年 | 10篇 |
1992年 | 79篇 |
1991年 | 55篇 |
1990年 | 66篇 |
1989年 | 40篇 |
1988年 | 27篇 |
1987年 | 39篇 |
1986年 | 27篇 |
1985年 | 26篇 |
1984年 | 18篇 |
1983年 | 9篇 |
1981年 | 9篇 |
1980年 | 16篇 |
1979年 | 20篇 |
1978年 | 16篇 |
1977年 | 9篇 |
1975年 | 10篇 |
1973年 | 8篇 |
1972年 | 12篇 |
1971年 | 8篇 |
排序方式: 共有5484条查询结果,搜索用时 15 毫秒
1.
Geraghty Benjamin J. Dasgupta Archya Sandhu Michael Malik Nauman Maralani Pejman Jabehdar Detsky Jay Tseng Chia-Lin Soliman Hany Myrehaug Sten Husain Zain Perry James Lau Angus Sahgal Arjun Czarnota Gregory J. 《Journal of neuro-oncology》2022,156(3):579-588
Journal of Neuro-Oncology - Quantitative image analysis using pre-operative magnetic resonance imaging (MRI) has been able to predict survival in patients with glioblastoma (GBM). The study... 相似文献
2.
Jennifer Tseng MD 《Journal of surgical oncology》2020,122(1):11-14
What is important to think about in surgical education and technical skills training? Technical skills training is grounded in social cognitive theory and the concepts of modeling and self-efficacy. Cognitive and nontechnical learning is critical to supplement the overall proficiency of the surgical learner in performing an operation. Technical learning is cemented by deliberate practice and there is benefit to productive struggle and failure. External cognitive load should be minimized to maximized operative skills advancement. 相似文献
3.
Chien-Hua Tseng Ben-Jei Tsuang Chun-Ju Chiang Kai-Chen Ku Jeng-Sen Tseng Tsung-Ying Yang Kuo-Hsuan Hsu Kun-Chieh Chen Sung-Liang Yu Wen-Chung Lee Tsang-Wu Liu Chang-Chuan Chan Gee-Chen Chang 《Journal of thoracic oncology》2019,14(5):784-792
Introduction
For never-smokers (smoked <100 lifetime cigarettes), lung cancer (LC) has emerged as an important issue. We aimed to investigate the effects of prevalence changes in tobacco smoking and particulate matter (PM) 2.5 (PM2.5) levels on LC in Taiwan, in relation to contrasting PM2.5 levels, between Northern Taiwan (NT) and Southern Taiwan (ST).Methods
We reviewed 371,084 patients with LC to assess smoking prevalence and correlations between the incidence of adenocarcinoma lung cancer (AdLC) and non-AdLC. Two subsets were selected to assess different AdLC stage trends and the effect of PM2.5 on survival of patients with AdLC.Results
From 1995 to 2015, the proportion of male adult ever-smokers decreased from 59.4% to 29.9% whereas the female smoking rate remained low (3.2% to 5.3%). AdLC incidence in males and females increased from 9.06 to 23.25 and 7.05 to 24.22 per 100,000 population, respectively. Since 1993, atmospheric visibility in NT improved (from 7.6 to 11.5 km), but deteriorated in ST (from 16.3 to 4.2 km). The annual percent change in AdLC stages IB to IV was 0.3% since 2009 (95% confidence interval [CI]: -1.9%–2.6%) in NT, and 4.6% since 2007 (95% CI: 3.3%–5.8%) in ST; 53% patients with LC had never smoked. Five-year survival rates for never-smokers, those with EGFR wild-type genes, and female patients with AdLC were 12.6% in NT and 4.5% in ST (hazard ratio: 0.79, 95% CI: 0.70–0.90).Conclusions
In Taiwan, greater than 50% of patients with LC had never smoked. PM2.5 level changes can affect AdLC incidence and patient survival. 相似文献4.
Konstantinos Chouliaras MD Rebecca Senehi MD Cecilia G. Ethun MD MS George Poultsides MD Thuy Tran MD Valerie Grignol MD Thomas Clark Gamblin MD Kevin K. Roggin MD Jennifer Tseng MD Ryan C. Fields MD Sharon M. Weber MD Gregory B. Russell MS Edward A. Levine MD Kenneth Cardona MD Konstantinos Votanopoulos MD 《Journal of surgical oncology》2019,120(3):340-347
5.
Ying-Yi Liao I-Hsuan Chen Wei-Chun Hsu Han-Yun Tseng Ray-Yau Wang 《Annals of physical and rehabilitation medicine》2021,64(5):101492
BackgroundCognitive impairment is prevalent among frail older adults. Traditional exercise and exergaming positively affect cognition in healthy older people. However, few studies have investigated the effects of exergaming on cognition and brain activation in frail older adults.ObjectiveThis study compared the effect of Kinect based exergaming (EXER) and combined physical exercise (CPE) training on cognitive function and brain activation in frail older adults in Taiwan. We hypothesised that EXER would be superior to CPE in this population.MethodsWe randomised 46 community-dwelling frail older adults to the EXER or CPE group for 36 sessions (three 60-min training sessions per week) over 12 weeks. Outcome measures for cognitive function included global cognition measured by the Montreal Cognitive Assessment, executive function measured by the Executive Interview 25, verbal memory measured by the Chinese version of the California Verbal Learning Test, attention measured by the Stroop Colour and Word Test and Trail Making Test (part B), and working memory measured by spatial n-back tests. Prefrontal cortex activation during the global cognition test was documented with functional near-infrared spectroscopy (fNIRS).ResultsBoth groups improved significantly in global cognition (P < 0.05), executive function (P < 0.05), and attention (P < 0.05) after the 12-week intervention. The group × time interaction indicated that EXER training significantly enhanced global cognition more than CPE training (F(1,44) = 5.277, P = 0.026). Moreover, only the EXER group showed significant improvements in verbal (P < 0.05) and working (P < 0.05) memory after the intervention. The fNIRS hemodynamics data revealed decreased activation in prefrontal cortices of both groups (P < 0.05) during the post-training cognitive assessment, thereby suggesting greater neural efficiency; however, we found no significant group difference.ConclusionIn frail older adults, exergaming and CPE could improve cognitive function, most likely by increasing neural efficiency. Moreover, exergaming may be superior to CPE, particularly in improving global cognition. 相似文献
6.
Ammara A. Watkins Manuel Castillo-Angeles Rodrigo Calvillo-Ortiz Camila R. Guetter Mariam F. Eskander Eiman Ghaffarpasand Luis Anguiano-Landa Jennifer F. Tseng Arthur J. Moser Mark P. Callery Tara S. Kent 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2019,21(7):923-927
BackgroundPatients undergoing pancreatic resection frequently require rehabilitation facilities after hospital discharge. We evaluated the predictive role of validated markers of frailty on rehabilitation facility placement to identify patients who may require this service.MethodsSingle-center retrospective cohort study of patients who underwent pancreatic resection from 2010 to 2015. 90-day morbidity and mortality were calculated. Postoperative validated markers of frailty (Activities of Daily Living scale, Braden scale [assesses pressure ulcer risk, lower scores = higher risk] and Morse fall scale) were evaluated via multivariate regression to identify predictors of discharge to rehabilitation facility.Results470 patients with complete data were included. Mean age was 62 and 49.2% were male. Postoperative median length of stay (LOS) was 8 (IQR 7–10). 92 (19.66%) patients were discharged to rehabilitation facilities and 138 (29.49%) patients were readmitted within 90 days. On multivariate analysis, age, sex, LOS > 8 days, inpatient Comprehensive Complication Index (CCI) and initial Braden scale were predictive of rehabilitation placement.ConclusionA marker of frailty routinely collected daily by nursing staff, the Braden scale, is available to help surgeons predict the need for postoperative rehabilitation placement after pancreatic resection. Engaging discharge planning services for at-risk patients may help prevent delayed hospital discharge and should be further evaluated. 相似文献
7.
You-Sheng Lin Yun Chen Ya-Hui Tsai Sheng-Hong Tseng Kuen-Song Lin 《Journal of pediatric surgery》2021,56(7):1227-1232
BackgroundPatients with neuroblastoma, a common childhood malignancy, often have poor prognosis. It is mandatory to develop an accurate and efficient diagnostic tool for neuroblastomas, so that the treatment can be started early. Graphene quantum dot (GQD), a nanomaterial, can be used to carry proteins, genetic materials, or drugs. GD2, a disialoganglioside, is a surface antigen expressed on neuroblastoma. This study investigated the in vivo targeting and imaging of neuroblastomas using GD2-targeting GQDs.MethodsGQDs were synthesized and conjugated with anti-GD2 antibody (anti-GD2/GQDs). In vitro cytotoxicity of GQDs and anti-GD2/GQDs was studied in human neuroblastoma cells by 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide)-based colorimetric assay. The tumor tracking and imaging of anti-GD2/GQDs in mice were investigated by in vivo imaging system (IVIS).ResultsTreatment with GQDs or anti-GD2/GQDs induced no or mild cytotoxicity in fibroblasts and neuroblastoma cells. After co-incubation, GQDs and anti-GD2/GQDs were located in the cytoplasm and nucleus of neuroblastoma cells, with GQDs showing a blue fluorescence and anti-GD2/GQDs an orange/red emission. The IVIS images demonstrated accumulation of the fluorescence of anti-GD2/GQDs in the subcutaneous tumors in mice 24 h after intravenous injection of anti-GD2/GQDs.ConclusionsAnti-GD2/GQDs may potentially be used for the targeting and imaging of neuroblastomas in vivo. 相似文献
8.
9.
West Nile virus (WNV) nonstructural protein 3 (NS3) harbors the viral triphosphatase and helicase for viral RNA synthesis and, together with NS2B, constitutes the protease responsible for polyprotein processing. NS3 is a soluble protein, but it is localized to specialized compartments at the rough endoplasmic reticulum (RER), where its enzymatic functions are essential for virus replication. However, the mechanistic details behind the recruitment of NS3 from the cytoplasm to the RER have not yet been fully elucidated. In this study, we employed immunofluorescence and biochemical assays to demonstrate that NS3, when expressed individually and when cleaved from the viral polyprotein, is localized exclusively to the cytoplasm. Furthermore, NS3 appeared to be peripherally recruited to the RER and proteolytically active when NS2B was provided in trans. Thus, we provide evidence for a potential additional role for NS2B in not only serving as the cofactor for the NS3 protease, but also in recruiting NS3 from the cytoplasm to the RER for proper enzymatic activity. Results from our study suggest that targeting the interaction between NS2B and NS3 in disrupting the NS3 ER localization may be an attractive avenue for antiviral drug discovery. 相似文献