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1.
Paula Pessin Fábrega Branisso Claudia Pinto Marques Souza de Oliveira Hilton Muniz Leão Filho Fabiana Roberto Lima Aritânia Sousa Santos Marcio Correa Mancini Maria Edna de Melo Flair José Carrilho Manoel de Souza Rocha Paul Clark Henrique José Pereira Branisso Cintia Cercato 《Annals of hepatology》2022,27(4):100707
IntroductionAlthough hyperferritinemia may reflect the inflammatory status of patients with non-alcoholic fatty liver disease (NAFLD), approximately 33% of hyperferritinemia cases reflect real hepatic iron overload.AimTo evaluate a non-invasive method for assessing mild iron overload in patients with NAFLD using 3T magnetic resonance imaging (MRI) relaxometry, serum hepcidin, and the expression of ferritin subunits.MethodsThis cross-sectional study assessed patients with biopsy-proven NAFLD. MRI relaxometry was performed using a 3T scanner in all patients, and the results were compared with iron content determined by liver biopsy. Ferritin, hepcidin, and ferritin subunits were assessed and classified according to ferritin levels and to siderosis identified by liver biopsy.ResultsA total of 67 patients with NAFLD were included in the study. MRI revealed mild iron overload in all patients (sensitivity, 73.5%; specificity, 70%). For mild (grade 1) siderosis, the transverse relaxation rate (R2*) threshold was 58.9 s?1 and the mean value was 72.5 s?1 (SD, 33.9), while for grades 2/3 it was 88.2 s?1 (SD, 31.9) (p < 0.001). The hepcidin threshold for siderosis was > 30.2 ng/mL (sensitivity, 87%; specificity, 82%). Ferritin H and ferritin L subunits were expressed similarly in patients with NAFLD, regardless of siderosis. There were no significant differences in laboratory test results between the groups, including glucose parameters and liver function tests.ConclusionsMRI relaxometry and serum hepcidin accurately assessed mild iron overload in patients with dysmetabolic iron overload syndrome. 相似文献
2.
de Souza Gabriel Hernandez Machado Pandolfo Mariana Travi Bortoluzzi Eduardo Antunes da Silveira Teixeira Cleonice Rossetto Hebert Luís da Rosa Amanda Freitas Machado Renata Gondo da Fonseca Roberti Garcia Lucas 《Odontology / the Society of the Nippon Dental University》2022,110(3):535-544
Odontology - The purpose of this study was to investigate whether the root perforation repair with mineral aggregate-based cements affects the retention of customized fiberglass posts to bovine... 相似文献
3.
Kniggendorf Vinicius Souza Maria Eduarda Perrud Russo Thatiane de Lima Marcelo Andrade Grupenmacher Alex Treiger Regatieri Caio V. Dreyfuss Juliana L. 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(12):3847-3855
Graefe's Archive for Clinical and Experimental Ophthalmology - The purpose of this study was to measure the anti-angiogenic effect of N-desulfated Re–N-acetylated, a chemically modified... 相似文献
4.
Araujo Rafael Antonius Amaral Sávio Tolentino Arthur Zeballos Diana Montaño Iris Souza Lucca S. Lins-Kusterer Liliane Brites Carlos 《AIDS and behavior》2022,26(2):397-406
AIDS and Behavior - Depression is the leading cause of years lived with disability worldwide and PLWHIV present a higher risk of developing depressive symptoms. We aimed to evaluate depressive... 相似文献
5.
de Souza Júlia Ruete Yokoyama Ana Paula Magnus Mariana Munari Boin Ilka de Ataide Elaine Cristina Munhoz Derli Conceição Pereira Fabrício Bíscaro Luzo Angela Orsi Fernanda Andrade 《Journal of thrombosis and thrombolysis》2022,53(4):887-897
Journal of Thrombosis and Thrombolysis - The relationship between acidosis and coagulopathy has long been described in vitro and in trauma patients, but not yet in orthotopic liver transplantation... 相似文献
6.
Eric J. Lehrer MD MS Jason Gurewitz DO Kenneth Bernstein MS Dev Patel Douglas Kondziolka MD Ajay Niranjan MD MBA Zhishuo Wei MSc L. Dade Lunsford MD Timothy D. Malouff MD Henry Ruiz-Garcia MD Samir Patel MD Phillip A. Bonney MD Lindsay Hwang MD Cheng Yu PhD Gabriel Zada MD David Mathieu MD Claire Trudel MD Rahul N. Prasad MD Joshua D. Palmer MD Brianna M. Jones MD Sonam Sharma MD Kareem R. Fakhoury MD Chad G. Rusthoven MD Christopher P. Deibert MD Piero Picozzi MD Andrea Franzini MD Luca Attuati MD Cheng-Chia Lee MD PhD Huai-Che Yang MD Manmeet S. Ahluwalia MD MBA Jason P. Sheehan MD PhD Daniel M. Trifiletti MD 《Cancer》2022,128(7):1429-1438
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Whitley W. Aamodt MD MPH Teresa Waligorska MSc Junchao Shen BS Thomas F. Tropea DO MPH MSTR Andrew Siderowf MD MSCE Daniel Weintraub MD Murray Grossman MD David Irwin MD MSTR David A. Wolk MD Sharon X. Xie PhD John Q. Trojanowski MD PhD Leslie M. Shaw PhD Alice S. Chen-Plotkin MD 《Movement disorders》2021,36(12):2945-2950