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排序方式: 共有6713条查询结果,搜索用时 16 毫秒
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Vincenzo Di Nunno Veronica Mollica Matteo Santoni Lidia Gatto Riccardo Schiavina Michelangelo Fiorentino Eugenio Brunocilla Andrea Ardizzoni Francesco Massari 《Clinical genitourinary cancer》2019,17(5):e871-e877
In the past few years several hormonal agents have been tested in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC) leading to an impressive improvement in terms of metastases-free survival (MFS). We performed a meta-analysis aimed to: (1) estimate the pooled effect of new hormonal compounds in terms of MFS, overall survival (OS) in overall and specific subpopulations; and (2) estimate the effect of high-grade toxicities of these drugs. We identified 881 studies published between January 1, 2010 and February 16, 2018 on PubMed/Medline, Cochrane Library, and Scopus. Three randomized placebo controlled clinical trials were selected (PROSPER, SPARTAN, and ARAMIS). Because of the absence of individual data, all of the analyses performed were made on aggregated data provided in selected studies. We used the inverse variance technique for the meta-analysis of the hazard ratios collected for MFS and OS analysis. Fixed and randomized models were used. Relative risk and 95% confidence intervals and risk difference were estimated considering the number of Grade 3 adverse events in treatment and control arms. Administration of new hormonal compounds in nmCRPC patients led to a significant benefit in MFS in the overall population and in all subgroups analyzed. These agents might also improve OS but longer follow-up is needed to confirm this hypothesis. Indeed results of OS analysis should be carefully evaluated because none of the studies selected provided mature OS data. Administration of these agents resulted in a significant increased risk of treatment-related death, high cardiovascular toxicity, hypertension, fractures, and falls. Administration of new hormonal compounds prolongs the time of metastases occurrence and might prolong also survival in patients with nmCRPC. Treatment-related toxicity is an important issue because these agents increase the risk of death, cardiovascular toxicity, hypertension, fractures, and risk of falls. 相似文献
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Alessio Cortellini Sebastiano Buti Daniele Santini Fabiana Perrone Raffaele Giusti Marcello Tiseo Melissa Bersanelli Maria Michiara Antonino Grassadonia Davide Brocco Nicola Tinari Michele De Tursi Federica Zoratto Enzo Veltri Riccardo Marconcini Francesco Malorgio Carlo Garufi Marco Russano Cecilia Anesi Tea Zeppola Marco Filetti Paolo Marchetti Andrea Botticelli Gian Carlo Antonini Cappellini Federica De Galitiis Maria Giuseppa Vitale Roberto Sabbatini Sergio Bracarda Rossana Berardi Silvia Rinaldi Marianna Tudini Rosa Rita Silva Annagrazia Pireddu Francesco Atzori Rita Chiari Biagio Ricciuti Daniela Iacono Maria Rita Migliorino Antonio Rossi Giampiero Porzio Katia Cannita Valeria Ciciarelli Maria Concetta Fargnoli Paolo Antonio Ascierto Corrado Ficorella 《The oncologist》2019,24(6):e327-e337
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Valentina Becherucci Stefano Ermini Luisa Piccini Silvia Bisin Valentina Gori Francesca Gentile Riccardo Ceccantini Elena De Rienzo Barbara Bindi Paola Pavan Vanessa Cunial Elisa Allegro Francesca Brugnolo Daniela Maggio Daniela Calzolari Erika Maccarelli Silvia Galli Sonia Muricci Marco Berchielli Veronica Tintori Iacopo Sardi Franco Bambi 《Journal of clinical apheresis》2020,35(5):406-412
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Riccardo Zuccarino Valeria Prada Isabella Moroni Emanuela Pagliano Maria Foscan Giulia Robbiano Chiara Pisciotta Kayla Cornett Rosemary Shy Angelo Schenone Davide Pareyson Michael Shy Joshua Burns 《Journal of the peripheral nervous system : JPNS》2020,25(2):138-142
The Charcot‐Marie‐Tooth disease Pediatric Scale (CMTPedS) is a Rasch‐built clinical outcome measure of disease severity. It is valid, reliable, and responsive to change for children and adolescents aged 3 to 20 years. The aim of this study was to translate and validate an Italian version of the CMTPedS using a validated framework of transcultural adaptation. The CMTPedS (Italian) was translated and culturally adapted from source into Italian by two experts in CMT with good English language proficiency. The two translations were reviewed by a panel of experts in CMT. The agreed provisional version was back translated into English by a professional translator. The definitive Italian version was developed during a consensus teleconference by the same panel. CMT patients were assessed with the final version of the outcome measure and a subset had a second assessment after 2 weeks to evaluate test‐retest reliability. Seventeen patients with CMT aged 5 to 20 years (eight female) were evaluated with the CMTPedS (Italian), and test‐retest was performed in three patients. The CMTPedS (Italian) showed a high test‐retest reliability. No patient had difficulty in completing the scale. The instructions for the different items were clearly understood by clinicians and therefore the administration of the outcome measure was straight forward and easily understood by the children assessed. The CMTPedS (Italian) will be used for clinical follow‐up and in clinical research studies in the Italian population. The data is fully comparable to that obtained from the English language version. 相似文献
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