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Aneesh Dhorepatil Somedeb Ball Raktim K. Ghosh Meera Kondapaneni Carl J. Lavie 《The American journal of medicine》2019,132(3):312-324
Inflammation has proven in multiple studies to be responsible for the progression of cardiometabolic diseases and malignancies. The interleukin family has been critically associated with progression of atherosclerosis, insulin resistance, and various malignancies. Given the advent of pharmacologic interleukin-1 (IL-1) inhibition, this pathway can potentially be targeted to improve outcomes. In the recently concluded Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) trial, investigators looked at the potential role of IL-1 (especially IL-1β) inhibition in halting the progression of atherosclerosis. In the subset analysis of the data from this trial, IL-1β inhibition with canakinumab was found to have beneficial effects in other cardiometabolic diseases characterized by inflammation, like diabetes, stroke, and chronic kidney disease, and also in patients with lung cancer. In this article, we will try to review the current literature on the role of canakinumab in the treatment of cardiometabolic diseases and malignancies. 相似文献
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Emily K Wright Kerri L Novak Cathy Lu Remo Panaccione Subrata Ghosh Stephanie R Wilson 《Journal canadien de gastroenterologie》2015,29(8):445-447
Aims of treatment for Crohn disease have moved beyond the resolution of clinical symptoms to objective end points including endoscopic and radiological normality. Regular re-evaluation of disease status to safely, readily and reliably detect the presence of inflammation and complications is paramount. Improvements in sonographic technology over recent years have facilitated a growing enthusiasm among radiologists and gastroenterologists in the use of ultrasound for the assessment of inflammatory bowel disease. Transabdominal intestinal ultrasound is accurate, affordable and safe for the assessment of lumi-nal inflammation and complications in Crohn disease, and can be performed with or without the use of intravenous contrast enhancement. Perianal fistulizing disease is a common, complex and often treatment-refractory complication of Crohn disease, which requires regular radiological monitoring. Endoanal ultrasound is invasive, uncomfortable and yields limited assessment of the perineal region. Although magnetic resonance imaging of the pelvis is established, timely access may be a problem. Transperineal ultrasound has been described in small studies, and is an accurate, painless and cost-effective method for documenting perianal fluid collections, fistulas and sinus tracts. In the present article, the authors review the literature regarding perineal ultrasound for the assessment of perianal Crohn disease and use case examples to illustrate its clinical utility. 相似文献
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Palashpriya Das Ruchi Supekar Ritika Chatterjee Subrata Roy Anisa Ghosh Subhajit Biswas 《World journal of hepatology》2022,14(8):1692-1693
Addition of authors’ affiliation to "Hepatitis B virus detected in paper currencies in a densely populated city of India: A plausible source of horizontal trans mission?" World J Hepatol 2020 Oct 27; 12(10): 775-791. In this article, one of the affiliations of two authors was not mentioned. Ruchi Supekar, a joint first author and Subhajit Biswas, the corresponding author are affiliated to Academy of Scientific and Innovative Research (AcSIR) Ghaziabad- 201002, India. 相似文献
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Indian Journal of Pediatrics - 相似文献