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1.
Uptake of Adriamycin in tumour and surrounding brain tissue in patients with malignant gliomas 总被引:1,自引:0,他引:1
H. von Holst E. Knochenhauer H. Blomgren V. P. Collins L. Ehn M. Lindquist G. Norén C. Peterson 《Acta neurochirurgica》1990,104(1-2):13-16
Summary Eight patients with malignant gliomas verified on CT scan, received an intravenous injection of 50 mg of Adriamycin R, 24 hours prior to surgical removal of the tumour. Peroperatively, both tumour and surrounding tissue specimens were obtained for determination of the tissue concentrations of Adriamycin and its reduced metabolite Adriamycinol. It was found that Adriamycin could be detected in tumour tissue from all patients. The concentration varied between 0,9 and 4,6 nmol/g tissue. In contrast, Adriamycin could only be detected in surrounding brain tissue from one patient.In anin vitro study a human malignant glioma cell line (U-251 MG) was exposed to various concentrations of Adriamycin for 24 hours. It was found that an intracellular drug concentration above 30 nmol/g cells caused a concentration dependent inhibition of cell growth. Thus, it is likely that the poor effect of Adriamycin on patients with malignant gliomas is due to an ineffective drug accumulation in the tumour tissue. 相似文献
2.
A case of a pedunculated arachnoid cyst within the third ventricle is presented. The cyst was small so as not to appear as a significant expanding lesion on CT. The clinical history, however, suggested intermittent increase of the intracranial pressure. On CT there was some widening of the lateral and third ventricles, while the fourth ventricle had normal width. This finding in combination with the clinical history prompted further neuroradiologic examinations, including pneumoencephalography and ventriculography. The presence of a pedunculated mobile cystic lesion within the third ventricle was shown and its nature further elucidated by stereotactic puncture combined with contrast injection into the cyst. After emptying of the cyst, the patient has been free of symptoms during an observation time of 2 years. The diagnostic and differential diagnostic aspects are discussed and the value of traditional neuroradiologic methods emphasized. 相似文献
3.
Duvic Madeleine Chiao Nor Talpur Rakhshandra 《Journal of cutaneous medicine and surgery》2003,7(2):3-7
Journal of Cutaneous Medicine and Surgery - 相似文献
4.
Metallic taste has been reported from divers working with underwater electric welding and cutting. An in vitro model was designed to simulate the intraoral situation of the divers with respect to the magnetic field. Potentiostatic analyses were performed on amalgam samples exposed to AC and DC magnetic fields. Morphologic changes were analyzed using differential interference light microscopy and scanning electron microscopy. Chemical changes on the surface of the amalgam samples were analyzed with secondary ion mass spectrometry. Results demonstrated that dental amalgams exposed to a specific AC magnetic field underwent morphologic and chemical changes in the superficial amalgam layers. 相似文献
5.
Supportive treatment of patients with haematological disorders mainly takes the form of transfusions of blood and platelets,
and sometimes palliative chemotherapy is given. Most patients are treated in hospital or at the outpatient clinic. However,
it is often difficult for the patients to arrange to come to the hospital, as they need transport by ambulance or taxi and
sometimes a relative to help them. Throughout 1996 we offered such patients supportive treatment at home. A nurse was employed
on the project, who was supplied with a car and a mobile telephone. Treatment was given at home. In all, 17 patients were
treated, with a total of 90 blood and 40 platelet transfusions. At three visits chemotherapy was administered. No complications
were seen, and the patients felt safe and content. We conclude that supportive treatment at home is safe and well accepted
by patients and their relatives. In addition, the costs for transportation and hospital care of this patient group were reduced. 相似文献
6.
Isolation,Replication and Polyhedrin Gene Sequence of an Israeli Helicoverpa Armigera Single Nucleopolyhedrovirus 总被引:1,自引:0,他引:1
A local strain of Helicoverpa armigera baculovirus was isolated from infected H. armigera larvae. Infectivity to Helicoverpa
cells, restriction enzyme analysis and electron microscopy allowed its identification as a single embedded nucleopolyhedrovirus,
designated HaSNPV-IS. Analysis of DNA replication, protein synthesis and polyhedrin expression in HaSNPV-infected cells located
the late and very late phases of the viral cycle at 24 and 48 h after infection, respectively. The viral polyhedrin gene was
isolated and characterized. It encoded for a polypeptide of 246 amino acid residues. A 32 kDa polypeptide was identified by
immunoblot analysis using anti-polyhedrin antiserum. The HaSNPV-IS polyhedrin DNA sequence revealed 99.4% of homology to the
HzSNPV polyhedrin. The availability of this efficient replication system and the above knowledge paves the way to future genetic
engineering of the HaSNPV.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
7.
Molecular epidemiology of hospital-associated and community-acquired Clostridium difficile infection in a Swedish county 下载免费PDF全文
Norén T Akerlund T Bäck E Sjöberg L Persson I Alriksson I Burman LG 《Journal of clinical microbiology》2004,42(8):3635-3643
All episodes of Clostridium difficile associated diarrhea (CDAD) diagnosed in a defined population of 274,000 including one tertiary and two primary hospitals and their catchment areas were studied during 12 months. The annual CDAD incidence in the county was 97 primary episodes per 100,000, and 78% of all episodes were classified as hospital associated with a mean incidence of 5.3 (range, 1.4 to 6.5) primary episodes per 1,000 admissions. The incidence among hospitalized individuals was 1,300-fold higher than that in the community (33,700 versus 25 primary episodes per 100,000 persons per year), reflecting a 37-fold difference in antibiotic consumption (477 versus 13 defined daily doses [DDD]/1,000 persons/day) and other risk factors. Three tertiary hospital wards with the highest incidence (13 to 36 per 1,000) had CDAD patients of high age (median age of 80 years versus 70 years for other wards, P < 0.001), long hospital stay (up to 25 days versus 4 days), or a high antibiotic consumption rate (up to 2,427 versus 421 DDD/1,000 bed days). PCR ribotyping of C. difficile isolates available from 330 of 372 CDAD episodes indicated nosocomial acquisition of the strain in 17 to 27% of hospital-associated cases, depending on the time interval between index and secondary cases allowed (2 months or up to 12 months), and only 10% of recurrences were due to a new strain of C. difficile (apparent reinfection). In other words, most primary and recurring episodes were apparently caused by the patient's endogenous strain rather than by one of hospital origin. Typing also indicated that a majority of C. difficile strains belonged to international serotypes, and the distribution of types was similar within and outside hospitals and in primary and relapsing CDAD. However, type SE17 was an exception, comprising 22% of hospital isolates compared to 6% of community isolates (P = 0.008) and causing many minor clusters and a silent nosocomial outbreak including 36 to 44% of the CDAD episodes in the three high-incidence wards. 相似文献
8.
K. Norén C. Weistrand F. Karpe 《Archives of environmental contamination and toxicology》1999,37(3):408-414
The concentrations of chlorinated biphenyls (CBs), 1,1-bis(4-chlorophenyl)-2,2-dichloroethene (DDE), hexachlorobenzene (HCB),
and the methylsulfonyl metabolites of CBs (MeSO2-CBs) and DDE (MeSO2-DDE) were determined in human plasma samples and in the fractions obtained by ultracentrifugation of plasma into very-low-density
(VLDL), low-density (LDL), high-density (HDL) lipoprotein and lipoprotein depleted (LPDP) fractions (containing primarily
albumin). The concentrations of triacylglycerols, cholesterol, phospholipids, and apolipoprotein B (apoB) were determined.
The organochlorine compounds were associated with all fractions, but predominantly with the LPDP fraction. On an average 44%
of CBs, 61% of MeSO2-CBs, 73% of DDE, 77% of MeSO2-DDE, and 45% of HCB were distributed in the LPDP fraction. A tendency to greater association of 3-methylsulfonyl substituted
than of corresponding 4-methylsulfonyl substituted chlorobiphenyls to the LPDP fraction was noticed. Among the lipoprotein
fractions, LDL was the main carrier of HCB, DDE and CBs. MeSO2-DDE was predominantly found in HDL and MeSO2-CBs were distributed equally among the LDL and HDL fractions. Calculating the concentrations of organochlorine compounds
in relation to the content of apoB, the levels were about 10 times higher in VLDL than in LDL.
Received: 24 April 1998/Accepted: 24 April 1999 相似文献
9.
Twenty-five healthy infants were followed from the newborn period to the age of eighteen months, by evaluation of their neuromotor performance. Evaluation of the specific postural reaction patterns (as described by Vojta) did not seem to be any use as a "short-cut" for the early diagnosis of neuromotor abnormalities, a considerable number of deviations from the normal/optimal pattern being noted even in completely normal infants. 相似文献
10.
Ismail NA Saharan WS Zaleha MA Jaafar R Muhammad JA Razi ZR 《The journal of obstetrics and gynaecology research》2008,34(3):350-353
AIM: To compare the success, clinical outcomes, and maternal and neonatal complications between the Kiwi Omnicup and the Malmstrom metal cup in vacuum assisted delivery. METHODS: This was a prospective randomized comparative trial. Women who required vacuum assisted vaginal delivery were randomized into the Kiwi Omnicup (KO) group and the Malmstrom metal cup (MM) group. The vacuum assisted deliveries were conducted according to hospital protocol. Details of the procedure and delivery outcomes including success and complications were analyzed. RESULTS: One hundred and sixty-four women were recruited - 85 were assigned to vacuum assisted delivery using the KO and 79 the MM. One hundred percent delivery success was achieved with no significant differences between the two instruments in terms of maternal morbidity (P = 0.66). Six women in the MM group sustained post delivery complications in comparison to five in the KO group. Three babies were diagnosed with birth asphyxia in each group. More babies in the MM group were admitted to the Neonatal Intensive Care Unit (NICU) (10 babies versus 5 babies) and suffered complications (14 versus 12 babies), compared to the KO group, although the difference was not statistically significant. There were no intrapartum or neonatal deaths and of those admitted to the NICU, all were discharged within a week without any serious consequences. CONCLUSION: Kiwi Omnicup is an effective alternative to the currently available Malmstrom metal cup for vacuum assisted delivery with no increase in maternal or neonatal morbidity or mortality. 相似文献