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De Sarkar Sritama Sarkar Deblina Sarkar Avijit Dighal Aishwarya Staniek Katrin Gille Lars Chatterjee Mitali 《Parasitology research》2019,118(1):335-345
Parasitology Research - Berberine chloride, a plant-derived isoquinoline alkaloid, has been demonstrated to have leishmanicidal activity, which is mediated by generation of a redox imbalance and... 相似文献
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Introduction and hypothesis
This study aimed to evaluate any differences in the incidence of perineal trauma in women undergoing vaginal delivery following intrauterine fetal death (IUFD) versus live-births. This information would be of interest in evaluating the possible effect of fetal demise on the mechanism of labour in the second stage and thus may provide invaluable insights to contribute to our understanding of the impact of fetal tone on the mechanics of labour and delivery.Methods
323 women who delivered vaginally following IUFD were matched with 1,000 women with a live-birth for age, parity, gestation and birth weight. Women undergoing assisted vaginal delivery and/or episiotomy were excluded.Results
Women with an IUFD had a significantly lower risk of perineal trauma overall (relative risk 0.16) as well as a lower risk of obstetric anal sphincter injury specifically (RR 0.12).Conclusions
Women delivering vaginally after IUFD have a lower incidence of perineal trauma compared with women delivering a live infant. This may be due to differences in biomechanics following an IUFD. 相似文献4.
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R. W. Thergaonkar Ankita Narang Bahadur Singh Gurjar Pradeep Tiwari Mamta Puraswani Himanshi Saini Aditi Sinha Binuja Varma Mitali Mukerji Pankaj Hari Arvind Bagga 《Clinical and experimental nephrology》2018,22(3):653-660
Background
Genetic susceptibility to atypical hemolytic uremic syndrome (aHUS) may lie within genes regulating or activating the alternate complement and related pathways converging on endothelial cell activation.Methods
We tested 32 Indian patients of aHUS negative for antibodies to complement factor H for genetic variations in a panel of 15 genes, i.e., CFH, CFHR1-5, CFI, CFB, C3, CD46, MASP2, DGKE, ADAMTS13, THBD and PLG using next-generation DNA sequencing and for copy number variation in CFHR1-3.Results
Despite absence of a public database of exome variations in the Indian population and limited functional studies, we could establish a genetic diagnosis in 6 (18.8%) patients using a stringent scheme of prioritization. One patient carried a likely pathogenic variation. The number of patients carrying possibly pathogenic variation was as follows: 1 variation: 5 patients, 2 variations: 9 patients, 3 variations: 5 patients, 4 variations: 9 patients, 5 variations: 2 patients and 6 variations: 2 patients. Homozygous deletion of CFHR1-3 was present in five patients; none of these carried a diagnostic genetic variation. Patients with or without diagnostic variation did not differ significantly in terms of enrichment of genetic variations that were rare/novel or predicted deleterious, or for possible environmental triggers.Conclusion
We conclude that genetic testing for multiple genes in patients with aHUS negative for anti-FH antibodies reveals multiple candidate variations that require prioritization. Population data on variation frequency of the Indian population and supportive functional studies are likely to improve diagnostic yield.7.
Priya Ranganathan Manju Sengar Girish Chinnaswamy Gaurav Agrawal Rajkumar Arumugham Rajiv Bhatt Ramesh Bilimagga Jayanta Chakrabarti Arun Chandrasekharan Harit Kumar Chaturvedi Rajiv Choudhrie Mitali Dandekar Ashok Das Vineeta Goel Caleb Harris Sujai Kolnadguthu Hegde Narendra Hulikal Deepa Joseph C S Pramesh 《The lancet oncology》2021,22(7):970-976
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Evaluation of direct agglutination test (DAT) and ELISA for serodiagnosis of visceral leishmaniasis in India 总被引:2,自引:0,他引:2
A Pal K Mukerji D Basu K Naskar K K Mallick D K Ghosh 《Journal of clinical laboratory analysis》1991,5(5):303-306
The direct agglutination test (DAT) and the enzyme-linked immunosorbent assay (ELISA) were used for serodiagnosis of parasitologically confirmed Indian visceral leishmaniasis (VL) cases. All the sera of VL cases were positive by both the methods. DAT titres of VL cases were greater than or equal to 1:3,200, and ELISA values were greater than or equal to 0.55 1:400 dilution. In the control group, sera of widely prevalent diseases of India, such as leprosy, tuberculosis, malaria, and liver cirrhosis, were included. Both tests could discriminate between VL and other patients of the control group. The sera of post-kala-azar dermal leishmaniasis (PKDL) patients gave OD values of greater than 0:55 and had DAT titres of 1:1,600. Both tests are sensitive and specific for the diagnosis of VL cases. DAT, being simpler and more economical, will be suitable for diagnosis and epidemiological studies for VL under rural conditions of India. 相似文献
10.
Saptarshi Mukerji Lyle Moncur Brendon Sanders Alex Currie Alistair Watson Karen Leeman 《The Australasian medical journal》2013,6(7):367-370
Tuberculosis (TB) of the cervix is a rare disease, especially in developed countries. We presented a patient with primary TB of the cervix with no concurrent immune deficiency or HIV infections. The case clinically mimicked carcinoma of the cervix. Difficulties in diagnosis have been discussed. Given the recent increase in migration patterns including travel from TB endemic areas, an abnormal-looking cervix should be regarded with a degree of suspicion for TB. 相似文献