全文获取类型
收费全文 | 3150篇 |
免费 | 241篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 101篇 |
妇产科学 | 72篇 |
基础医学 | 501篇 |
口腔科学 | 35篇 |
临床医学 | 340篇 |
内科学 | 677篇 |
皮肤病学 | 48篇 |
神经病学 | 304篇 |
特种医学 | 105篇 |
外科学 | 368篇 |
综合类 | 27篇 |
一般理论 | 4篇 |
预防医学 | 221篇 |
眼科学 | 78篇 |
药学 | 206篇 |
中国医学 | 12篇 |
肿瘤学 | 277篇 |
出版年
2024年 | 3篇 |
2023年 | 30篇 |
2022年 | 24篇 |
2021年 | 107篇 |
2020年 | 75篇 |
2019年 | 101篇 |
2018年 | 123篇 |
2017年 | 88篇 |
2016年 | 115篇 |
2015年 | 136篇 |
2014年 | 155篇 |
2013年 | 191篇 |
2012年 | 293篇 |
2011年 | 268篇 |
2010年 | 167篇 |
2009年 | 143篇 |
2008年 | 203篇 |
2007年 | 171篇 |
2006年 | 173篇 |
2005年 | 187篇 |
2004年 | 161篇 |
2003年 | 151篇 |
2002年 | 137篇 |
2001年 | 34篇 |
2000年 | 17篇 |
1999年 | 23篇 |
1998年 | 28篇 |
1997年 | 18篇 |
1996年 | 10篇 |
1995年 | 13篇 |
1994年 | 9篇 |
1993年 | 9篇 |
1992年 | 12篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 1篇 |
1987年 | 1篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1969年 | 1篇 |
1968年 | 2篇 |
排序方式: 共有3406条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
AbstractThis is a secondary analysis of three qualitative studies about MAiD in which researchers asked about the differences between suicide and MAiD. In all, researchers interviewed 52 Canadians; 7 were people who had requested MAiD and had been found ineligible, 6 were MAiD providers and 39 were socially and economically marginalized. The overwhelming response was that MAiD is better than suicide in the context of suffering at the end of life. Whereas these people perceived suicide as uncertain, difficult, and something that was usually done alone and without support, they thought MAiD was certain, painless, and more socially acceptable. 相似文献
5.
6.
7.
Normal Pediatric Data for Isovolumic Acceleration at the Lateral Tricuspid Valve Annulus—A Heart Rate – Dependent Measure of Right Ventricular Contractility 下载免费PDF全文
8.
Cristina Cadenas Sonja Vosbeck Karolina Edlund Katharina Grgas Katrin Madjar Birte Hellwig Alshaimaa Adawy Annika Glotzbach Joanna D. Stewart Michaela S. Lesjak Dennis Franckenstein Maren Claus Heiko Hayen Alexander Schriewer Kathrin Gianmoena Sonja Thaler Marcus Schmidt Patrick Micke Fredrik Pontén Adil Mardinoglu Cheng Zhang Heiko U. Käfferlein Carsten Watzl Saša Frank Jörg Rahnenführer Rosemarie Marchan Jan G. Hengstler 《International journal of cancer. Journal international du cancer》2019,145(4):901-915
Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL). LIPG was recently reported to be expressed in breast cancer and to support proliferation, tumourigenicity and metastasis. Here we show that severe oxidative stress leading to AMPK activation triggers LIPG upregulation, resulting in intracellular lipid droplet accumulation in breast cancer cells, which supports survival. Neutralizing oxidative stress abrogated LIPG upregulation and the concomitant lipid storage. In human breast cancer, high LIPG expression was observed in a limited subset of tumours and was significantly associated with shorter metastasis-free survival in node-negative, untreated patients. Moreover, expression of PLIN2 and TXNRD1 in these tumours indicated a link to lipid storage and oxidative stress. Altogether, our findings reveal a previously unrecognized role for LIPG in enabling oxidative stress-induced lipid droplet accumulation in tumour cells that protects against oxidative stress, and thus supports tumour progression. 相似文献
9.
Stanislas Grassin‐Delyle Michaela Semeraro Frantz Foissac Naim Bouazza Haleema Shakur‐Still Ian Roberts Jean‐Marc Treluyer Saïk Urien 《Fundamental & clinical pharmacology》2019,33(6):670-678
Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss and death due to bleeding after trauma and post‐partum haemorrhage. One key issue for treatment success is early administration. While usually given intravenously, oral and intramuscular use would be useful in specific circumstances. Therefore, an understanding of TXA pharmacokinetics when given via different routes is valuable. The aim of this study was to perform an individual participant data meta‐analysis of pharmacokinetic studies with TXA given to healthy volunteers via different routes. We searched the following databases: PubMed, Web of Science, Wiley Online Library, Elsevier Science Direct and J‐STAGE. Individual subject data were extracted when available, otherwise arithmetic means were used. A population pharmacokinetic model was developed using nonlinear mixed effect modelling. Seven studies were included in the analysis with data from 10 patients for the IV route, six patients for the IM route and 114 patients for the oral route. The pharmacokinetics was ascribed to a two‐compartment model, and the main covariate was allometrically scaled bodyweight. Oral and IM bioavailabilities were 46 and 105%, respectively. For a 70 kg bodyweight, the population estimates were 7.6 L/h for clearance, 17.9 L for the volume of the central compartment, 2.5 L/h for the diffusional clearance and 16.6 L for the peripheral volume of distribution. Larger well‐designed studies are needed to describe the pharmacokinetics of TXA when given IM or as an oral solution before these can be recommended as alternatives to IV. 相似文献
10.