首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   4134篇
  免费   268篇
  国内免费   10篇
耳鼻咽喉   32篇
儿科学   138篇
妇产科学   112篇
基础医学   621篇
口腔科学   31篇
临床医学   521篇
内科学   894篇
皮肤病学   69篇
神经病学   332篇
特种医学   60篇
外科学   409篇
综合类   56篇
一般理论   3篇
预防医学   561篇
眼科学   45篇
药学   210篇
中国医学   4篇
肿瘤学   314篇
  2023年   31篇
  2022年   19篇
  2021年   101篇
  2020年   59篇
  2019年   101篇
  2018年   116篇
  2017年   68篇
  2016年   89篇
  2015年   92篇
  2014年   129篇
  2013年   200篇
  2012年   302篇
  2011年   344篇
  2010年   151篇
  2009年   162篇
  2008年   277篇
  2007年   290篇
  2006年   275篇
  2005年   225篇
  2004年   224篇
  2003年   184篇
  2002年   162篇
  2001年   41篇
  2000年   52篇
  1999年   45篇
  1998年   27篇
  1997年   38篇
  1996年   20篇
  1995年   30篇
  1994年   22篇
  1993年   25篇
  1992年   40篇
  1991年   32篇
  1990年   44篇
  1989年   39篇
  1988年   31篇
  1987年   24篇
  1986年   33篇
  1985年   26篇
  1984年   24篇
  1983年   15篇
  1982年   15篇
  1980年   11篇
  1979年   16篇
  1977年   11篇
  1975年   10篇
  1974年   9篇
  1970年   10篇
  1969年   10篇
  1968年   18篇
排序方式: 共有4412条查询结果,搜索用时 15 毫秒
1.
2.
We describe two cases of acute‐onset erythema, peeling, and pruritus or tenderness isolated to the palmar surface of the hands. A detailed exposure history revealed significant periods of contact with homemade slime; given the clinical findings and timing of exposure, acute contact dermatitis of the hands was suspected. Symptoms and clinical findings resolved after avoidance of the suspected causative contactants. There are few if any reported cases of contact dermatitis to homemade slime in the literature; this serves to highlight the importance of a thorough exposure history in the evaluation of hand dermatitis.  相似文献   
3.
4.
5.
BackgroundAtopic dermatitis (AD) is associated with a substantial burden on quality of life (QoL).ObjectiveTo evaluate the effects of tralokinumab on health-related QoL in patients with moderate-to-severe AD using patient-reported outcomes.MethodsThis was a phase 2b, randomized, double-blind, placebo-controlled, dose-ranging study in adults with moderate-to-severe AD. The patients received subcutaneous tralokinumab or placebo (1:1:1:1) every 2 weeks for 12 weeks and class 3 topical corticosteroid cream or ointment at least once daily from the run-in to end of follow-up. Patient-reported outcome end points were change from baseline to week 12 in the Dermatology Life Quality Index (dermatology life quality index (DLQI); prespecified secondary objective), the Short Form 36 Health Survey (SF-36) version 2, and sleep interference numeric rating scale score (prespecified exploratory objectives).ResultsA total of 204 patients were randomized to placebo (n = 51) or tralokinumab (45 mg, n = 50; 150 mg, n = 51; 300 mg, n = 52). Tralokinumab 300 mg every 2 weeks improved total Dermatology Life Quality Index vs placebo at week 12 (placebo-adjusted mean change, ?3.51 [95% confidence interval, ?6.00 to ?1.02]). At week 12, both the mental component summary (4.23 [0.98-7.47]) and the physical component summary (4.26 [1.83-6.69]) and all 8 domains of the Short Form 36 Health Survey were improved in patients treated with tralokinumab 300 mg vs placebo. Sleep interference was improved at week 12 with all tralokinumab doses vs placebo.ConclusionTralokinumab improved health-related QoL in patients with moderate-to-severe atopic dermatitis, providing further evidence of the value of targeting interleukin-13 in such patients.Trial RegistrationClinicalTrials.gov identifier: NCT02347176; https://clinicaltrials.gov/ct2/show/NCT02347176.  相似文献   
6.
Bacteria, Archaea, Eukarya and viruses coexist in the human gut, and this coexistence is functionally balanced by symbiotic or antagonistic relationships. Antagonism is often characterized by the production of antimicrobials against other organisms occupying the same environmental niche. Indeed, close co-evolution in the gut has led to the development of specialized antimicrobials, which is attracting increased attention as these may serve as novel alternatives to antibiotics and thereby help to address the global problem of antimicrobial resistance. The gastrointestinal (GI) tract is especially suitable for finding novel antimicrobials due to the vast array of microbes that inhabit it, and a considerable number of antimicrobial producers of both wide and narrow spectrum have been described. In this review, we summarize some of the antimicrobial compounds that are produced by bacteria isolated from the gut environment, with a special focus on bacteriocins. We also evaluate the potential therapeutic application of these compounds to maintain homeostasis in the gut and the biocontrol of pathogenic bacteria.  相似文献   
7.
8.
9.
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号