全文获取类型
收费全文 | 9791篇 |
免费 | 425篇 |
国内免费 | 61篇 |
专业分类
耳鼻咽喉 | 71篇 |
儿科学 | 219篇 |
妇产科学 | 52篇 |
基础医学 | 1312篇 |
口腔科学 | 204篇 |
临床医学 | 474篇 |
内科学 | 2779篇 |
皮肤病学 | 167篇 |
神经病学 | 745篇 |
特种医学 | 332篇 |
外科学 | 1495篇 |
综合类 | 45篇 |
预防医学 | 253篇 |
眼科学 | 213篇 |
药学 | 683篇 |
中国医学 | 61篇 |
肿瘤学 | 1172篇 |
出版年
2023年 | 35篇 |
2022年 | 27篇 |
2021年 | 127篇 |
2020年 | 69篇 |
2019年 | 98篇 |
2018年 | 153篇 |
2017年 | 96篇 |
2016年 | 135篇 |
2015年 | 154篇 |
2014年 | 202篇 |
2013年 | 276篇 |
2012年 | 474篇 |
2011年 | 531篇 |
2010年 | 302篇 |
2009年 | 294篇 |
2008年 | 539篇 |
2007年 | 558篇 |
2006年 | 582篇 |
2005年 | 611篇 |
2004年 | 622篇 |
2003年 | 610篇 |
2002年 | 648篇 |
2001年 | 224篇 |
2000年 | 204篇 |
1999年 | 207篇 |
1998年 | 191篇 |
1997年 | 141篇 |
1996年 | 109篇 |
1995年 | 129篇 |
1994年 | 127篇 |
1993年 | 131篇 |
1992年 | 171篇 |
1991年 | 141篇 |
1990年 | 163篇 |
1989年 | 127篇 |
1988年 | 94篇 |
1987年 | 119篇 |
1986年 | 111篇 |
1985年 | 88篇 |
1984年 | 67篇 |
1983年 | 52篇 |
1982年 | 62篇 |
1981年 | 50篇 |
1980年 | 43篇 |
1979年 | 38篇 |
1978年 | 32篇 |
1977年 | 25篇 |
1976年 | 25篇 |
1975年 | 27篇 |
1972年 | 27篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
1.
2.
3.
Eriko Yanagida Hiroaki Miyoshi Mai Takeuchi Noriaki Yoshida Kazutaka Nakashima Kyohei Yamada Takeshi Umeno Yasumasa Shimasaki Takuya Furuta Masao Seto Koichi Ohshima 《Hematological oncology》2020,38(5):680-688
The interaction of CD47 and signal-regulatory protein alpha (SIRPα) induces “don't eat me signal”, leading suppression of phagocytosis. This signal can affect the clinical course of malignant disease. Although CD47 and SIRPα expression are associated with clinicopathological features in several neoplasms, the investigation for adult T-cell leukemia/lymphoma (ATLL) has not been well-documented. This study aimed to declare the association between CD47 and SIRPα expression and clinicopathological features in ATLL. We performed immunostaining on 73 biopsy samples and found that CD47 is primarily expressed in tumor cells, while SIRPα is expressed in non-neoplastic stromal cells. CD47 positive cases showed significantly higher FoxP3 (P = .0232) and lower CCR4 (P = .0214). SIRPα positive cases presented significantly better overall survival than SIRPα negative cases (P = .0132). SIRPα positive cases showed significantly HLA class I (P = .0062), HLA class II (P = .0133), microenvironment PD-L1 (miPD-L1) (P = .0032), and FoxP3 (P = .0229) positivity. In univariate analysis, SIRPα expression was significantly related to prognosis (Hazard ratio [HR] 0.470; 95% confidence interval [CI] 0.253-0.870; P = .0167], although multivariate analysis did not show SIPRα as an independent prognostic factor. The expression of SIRPα on stromal cells reflects activated immune surveillance mechanism in tumor microenvironment and induce good prognosis in ATLL. More detailed studies for gene expression or genomic abnormalities will disclose clinical and biological significance of the CD47 and SIRPα in ATLL. 相似文献
4.
Noriaki Yoshida Hiroaki Miyoshi Fumiko Arakawa Kazutaka Nakashima Keisuke Kawamoto Masao Seto Koichi Ohshima 《Hematological oncology》2020,38(5):673-679
Follicular lymphoma (FL) is a germinal center-derived B-cell lymphoma that is known to proliferate in the intrafollicular region. However, lymphoma cells can be identified in the extrafollicular regions, which are related to disease dissemination. We purified the intrafollicular and extrafollicular regions of FL cells by laser microdissection and conducted microarray analysis in order to characterize the gene expression profiles of FL cells from both regions. BCL2 and genes of germinal B-cell markers clearly separated intrafollicular and extrafollicular regions of reactive follicular hyperplasia, suggesting the adequacy of the current analysis. In FL cases, cytokine-related genes were significantly enriched in extrafollicular regions compared with those in the intrafollicular regions. In intrafollicular regions of FL, cell-cycle–related genes were enriched. We found that the FL cells in the extrafollicular region more strongly expressed IL3RA and CXCL12 than those of intrafollicular regions. The cytokines might be also derived from stroma cells in the extrafollicular regions, which may initiate activation and migration of the tumor cells to this region. Our results suggest that FL cell interaction with surrounding stroma cells plays an important role in the pathophysiology of FL and that such interactions should be a good target for therapy. 相似文献
5.
Yasushi Sawayama Hidehiro Itonaga Takuya Fukushima Nobuaki Nakano Hiroshi Fujiwara Atae Utsunomiya Takahiro Fukuda Toshihiro Miyamoto Tetsuya Eto Kaname Miyashita Hirohisa Nakamae Masao Ogata Atsushi Yamanoha Yasuhiko Miyazaki Junya Kanda Yoshiko Atsuta Koji Kato ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation 《American journal of hematology》2019,94(5):E143-E146
6.
Marie Ohata Susumu Fujiwara Ai Yoshioka Hiroshi Nagai Shintaro Sugita Nozomi Yamano Yusuke Inoue Chikako Nishigori 《Pediatric dermatology》2019,36(6):997-998
Fibroblastic connective tissue nevus (FCTN) is a benign cutaneous mesenchymal lesion characterized by proliferation of CD34‐positive fibroblastic/myofibroblastic spindle‐shaped cells. We report a case of agminated FCTN on the right lower abdomen of a 1‐year‐old boy. 相似文献
7.
8.
9.
Hideta Nakamura Kazuya Miyagi Mariko Otsuki Yuuri Higure Naoya Nishiyama Takeshi Kinjo Masashi Nakamatsu Shusaku Haranaga Masao Tateyama Jiro Fujita 《Internal medicine (Tokyo, Japan)》2020,59(22):2945
Treatment with tocilizumab (TCZ) to block interleukin-6 (IL-6) signalling is predicted to mitigate cytokine release syndrome (CRS) caused by coronavirus disease 2019 (COVID-19). However, the adverse effects of TCZ on patients with COVID-19 remain unclear. We herein report a patient with COVID-19 treated with TCZ who developed acute hypertriglyceridaemia. Despite favipiravir treatment, acute respiratory distress syndrome developed in a 45-year-old patient with COVID-19; thus, TCZ was initiated. The triglyceride levels greatly increased after TCZ administration. Physicians should consider the negative impact of TCZ on the lipid profile in patients with COVID-19, although COVID-19-induced CRS itself may be an aggravating factor. 相似文献
10.
Tomokazu AOKI Yoshitaka NARITA Kazuhiko MISHIMA Masao MATSUTANI 《Neurologia medico-chirurgica》2020,60(12):600
Palliative care and advance care planning (ACP) from the first diagnosis of glioblastoma are important. This questionnaire survey was conducted to understand the current status of palliative care for brain tumors in Japan. Representative characteristics of Japan in comparison with Western countries (P <0.01) are described below: (1) Gender ratio of male in physicians who treat brain tumors in Europe and the United States/Canada are about 70%, but 94% in Japan. (2) The specialty is predominantly neurosurgeon (93%) in Japan. The ratio of neurologists is predominantly 40% in Europe. In the United States/Canada, neurologist (27%) and neurosurgeon (29%) are main parts. (3) Years of medical experience over 15 in physicians is 73% in Japan. Proportions of those with over 15 years are 45% in Europe and 30% in the United States/Canada. (4) In practicing setting, the rate of academic medical centers is about 80% in Europe and the United States/Canada, and ~60% in Japan. Representative differences compared with past domestic data (2007) (P <0.01): (1) In glioblastoma, the rate of explaining about median survival time increases from 39% (2007) to 80% (2018). Explanation about medical conditions to the patient himself with his family increases from 20% (2007) to 39% (2018). (2) Place of death: The rate at hospital is decreasing from 96% (2007) to 79% (2018) and at home is increasing from 3% (2007) to 10% (2018) (3) The rate of ventilator in adult has decreased from 74% (2007) to 54% (2018), but nasal tube feeding has remained unchanged from 62% (2007) to 60% (2018). These results will be shared with physicians to make better care systems for patients with brain tumors. 相似文献