全文获取类型
收费全文 | 11920篇 |
免费 | 1100篇 |
国内免费 | 126篇 |
专业分类
耳鼻咽喉 | 188篇 |
儿科学 | 414篇 |
妇产科学 | 432篇 |
基础医学 | 1481篇 |
口腔科学 | 203篇 |
临床医学 | 1277篇 |
内科学 | 2264篇 |
皮肤病学 | 187篇 |
神经病学 | 1331篇 |
特种医学 | 648篇 |
外国民族医学 | 1篇 |
外科学 | 1277篇 |
综合类 | 373篇 |
一般理论 | 6篇 |
预防医学 | 1184篇 |
眼科学 | 151篇 |
药学 | 1016篇 |
中国医学 | 14篇 |
肿瘤学 | 699篇 |
出版年
2021年 | 156篇 |
2020年 | 125篇 |
2019年 | 173篇 |
2018年 | 195篇 |
2017年 | 173篇 |
2016年 | 207篇 |
2015年 | 204篇 |
2014年 | 313篇 |
2013年 | 414篇 |
2012年 | 554篇 |
2011年 | 593篇 |
2010年 | 340篇 |
2009年 | 284篇 |
2008年 | 514篇 |
2007年 | 540篇 |
2006年 | 482篇 |
2005年 | 502篇 |
2004年 | 436篇 |
2003年 | 421篇 |
2002年 | 415篇 |
2001年 | 377篇 |
2000年 | 407篇 |
1999年 | 342篇 |
1998年 | 201篇 |
1997年 | 199篇 |
1996年 | 203篇 |
1995年 | 160篇 |
1994年 | 150篇 |
1993年 | 148篇 |
1992年 | 221篇 |
1991年 | 254篇 |
1990年 | 283篇 |
1989年 | 252篇 |
1988年 | 223篇 |
1987年 | 250篇 |
1986年 | 206篇 |
1985年 | 254篇 |
1984年 | 172篇 |
1983年 | 123篇 |
1982年 | 99篇 |
1981年 | 89篇 |
1980年 | 99篇 |
1979年 | 119篇 |
1978年 | 110篇 |
1977年 | 82篇 |
1976年 | 94篇 |
1975年 | 88篇 |
1974年 | 103篇 |
1973年 | 89篇 |
1972年 | 86篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Stefanie Hassel Gulshan B. Sharma Gsine L. Alders Andrew D. Davis Stephen R. Arnott Benicio N. Frey Geoffrey B. Hall Jacqueline K. Harris Raymond W. Lam Roumen Milev Daniel J. Müller Susan Rotzinger Mojdeh Zamyadi Sidney H. Kennedy Stephen C. Strother Glenda M. MacQueen 《Human brain mapping》2020,41(6):1400-1415
Task‐based functional neuroimaging methods are increasingly being used to identify biomarkers of treatment response in psychiatric disorders. To facilitate meaningful interpretation of neural correlates of tasks and their potential changes with treatment over time, understanding the reliability of the blood‐oxygen‐level dependent (BOLD) signal of such tasks is essential. We assessed test–retest reliability of an emotional conflict task in healthy participants collected as part of the Canadian Biomarker Integration Network in Depression. Data for 36 participants, scanned at three time points (weeks 0, 2, and 8) were analyzed, and intra‐class correlation coefficients (ICC) were used to quantify reliability. We observed moderate reliability (median ICC values between 0.5 and 0.6), within occipital, parietal, and temporal regions, specifically for conditions of lower cognitive complexity, that is, face, congruent or incongruent trials. For these conditions, activation was also observed within frontal and sub‐cortical regions, however, their reliability was poor (median ICC < 0.2). Clinically relevant prognostic markers based on task‐based fMRI require high predictive accuracy at an individual level. For this to be achieved, reliability of BOLD responses needs to be high. We have shown that reliability of the BOLD response to an emotional conflict task in healthy individuals is moderate. Implications of these findings to further inform studies of treatment effects and biomarker discovery are discussed. 相似文献
3.
4.
5.
Fluid role boundaries: exploring the contribution of the advanced nurse practitioner to multi‐professional palliative care 下载免费PDF全文
6.
Diffuse dermal angiomatosis: a contributory factor to ulceration in a patient with renal transplant 下载免费PDF全文
We present the case of a 54‐year‐old patient with renal transplant who developed unusual vascular changes on the forearm distal to a functioning arteriovenous fistula, as well as a painful ulcerated lesion on her anterior abdominal wall. We believe that the diffuse dermal angioendotheliomatosis variant of reactive angioendotheliomatosis had a role in the pathogenesis of this patient's lesions. 相似文献
7.
Pancreaticoduodenal artery aneurysm is a rare complication of coeliac artery stenosis secondary to a low lying median arcuate coeliac ligament. This article reports the case of a 69-year old man who presented with left arm and leg weakness, clinically in keeping with right hemisphere stroke. Initial CT brain scan was within normal limits. The patient did not receive thrombolysis as he was outside the time window. 3 hours later the patient experienced sudden onset epigastric pain and acute shock. CT aorta abdominal was diagnostic of a ruptured inferior pancreaticoduodenal artery aneurysm. Repeat CT brain the following day showed subacute infarction within the right frontal lobe. Embolisation of the aneurysm was successfully performed. It is well documented that ischaemic stroke can cause acute hypertension. This acute hypertension probably contributed to the rupture of the pancreaticoduodenal artery aneurysm. The patient was well on discharge and remains well 2 months on. 相似文献
8.
John P. Sundberg Kathleen A. Silva Victoria E. Kennedy John J. Wilson Nicholas E. Gott Beth A. Sundberg Derry C. Roopenian 《Experimental dermatology》2019,28(9):1091-1093
2‐deoxy D‐glucose (2DG) was tested for efficacy in treating alopecia areata using the C3H/HeJ skin graft model. 2DG has proven to be efficacious in treatment of various mouse models of autoimmunity with minimal serious side effects noted. This agent has been shown to normalize abnormally activated T‐cell populations while also preventing cell surface expression of NKG2D; key factors defining alopecia areata disease progression. Daily oral ingestion of 2DG via drinking water to mice with patchy or diffuse alopecia areata for 16 weeks failed to prevent expansion of alopecia or cause regrowth of hair in treated mice. Histologically, there were no differences between treated and control groups. These results indicate that, while 2DG is effective for some autoimmune diseases, it was not efficacious for the cell‐mediated autoimmune mouse disease, alopecia areata. 相似文献
9.
Partha Sardar Deepak L. Bhatt Ajay J. Kirtane Kevin F. Kennedy Saurav Chatterjee Jay Giri Peter A. Soukas William B. White Sahil A. Parikh Herbert D. Aronow 《Journal of the American College of Cardiology》2019,73(13):1633-1642
Background
There are conflicting data regarding the relative effectiveness of renal sympathetic denervation (RSD) in patients with hypertension.Objectives
The purpose of this study was to evaluate the blood pressure (BP) response after RSD in sham-controlled randomized trials.Methods
Databases were searched through June 30, 2018. Randomized trials (RCTs) with ≥50 patients comparing catheter-based RSD with a sham control were included. The authors calculated summary treatment estimates as weighted mean differences (WMD) with 95% confidence intervals (CIs) using random-effects meta-analysis.Results
The analysis included 977 patients from 6 trials. The reduction in 24-h ambulatory systolic blood pressure (ASBP) was significantly greater for patients treated with RSD than sham procedure (WMD ?3.65 mm Hg, 95% CI: ?5.33 to ?1.98; p < 0.001). Compared with sham, RSD was also associated with a significant decrease in daytime ASBP (WMD ?4.07 mm Hg, 95% CI: ?6.46 to ?1.68; p < 0.001), office systolic BP (WMD ?5.53 mm Hg, 95% CI: ?8.18 to ?2.87; p < 0.001), 24-h ambulatory diastolic BP (WMD ?1.71 mm Hg, 95% CI: ?3.06 to ?0.35; p = 0.01), daytime ambulatory diastolic BP (WMD ?1.57 mm Hg, 95% CI: ?2.73 to ?0.42; p = 0.008), and office diastolic BP (WMD ?3.37 mm Hg, 95% CI: ?4.86 to ?1.88; p < 0.001). Compared with first-generation trials, a significantly greater reduction in daytime ASBP was observed with RSD in second-generation trials (6.12 mm Hg vs. 2.14 mm Hg; p interaction = 0.04); however, this interaction was not significant for 24-h ASBP (4.85 mm Hg vs. 2.23 mm Hg; p interaction = 0.13).Conclusions
RSD significantly reduced blood pressure compared with sham control. Results of this meta-analysis should inform the design of larger, pivotal trials to evaluate the long-term efficacy and safety of RSD in patients with hypertension. 相似文献10.