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Martha L.P. MacLeod Kelly L. Penz Davina Banner Sharleen Jahner Irene Koren Alexandra Thomlinson Pertice Moffitt Mary Ellen Labrecque 《International journal of mental health nursing》2022,31(1):128-141
Access to and delivery of quality mental health services remains challenging in rural and remote Canada. To improve access, services, and support providers, improved understanding is needed about nurses who identify mental health as an area of practice. The aim of this study is to explore the characteristics and context of practice of registered nurses (RNs), licensed practical nurses (LPNs), and registered psychiatric nurses (RPNs) in rural and remote Canada, who provide care to those experiencing mental health concerns. Data were from a pan-Canadian cross-sectional survey of 3822 regulated nurses in rural and remote areas. Individual and work community characteristics, practice responsibilities, and workplace factors were analysed, along with responses to open-ended questions. Few nurses identified mental health as their sole area of practice, with the majority of those being RPNs employed in mental health or crisis centres, and general or psychiatric hospitals. Nurses who indicated that mental health was only one area of their practice were predominantly employed as generalists, often working in both hospital and primary care settings. Both groups experienced moderate levels of job resources and demands. Over half of the nurses, particularly LPNs, had recently experienced and/or witnessed violence. Persons with mental health concerns in rural and remote Canada often receive care from those for whom mental health nursing is only part of their everyday practice. Practice and education supports tailored for generalist nurses are, therefore, essential, especially to support nurses in smaller communities, those at risk of violence, and those distant from advanced referral centres. 相似文献
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Eric T. Hyde MPH Andrea Z. LaCroix PhD MPH Kelly R. Evenson PhD MS Annie Green Howard PhD Blake Anuskiewicz MS Chongzhi Di PhD John Bellettiere PhD MPH Michael J. LaMonte PhD MPH JoAnn E. Manson MD MPH DrPH Julie E. Buring ScD Eric J. Shiroma ScD I-Min Lee MBBS ScD Humberto Parada Jr. PhD MPH 《Cancer》2023,129(10):1579-1590
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da Cunha Kelly Francisco Kahl Julia Martinelli Magalhães Fiorentin Taís Regina Oliveira Karina Diniz Costa Jose Luiz 《Forensic Toxicology》2022,40(2):322-331
Forensic Toxicology - We have developed and validated a high-sensitivity method to quantify lysergic acid diethylamide (LSD) and 2-oxo-3-hydroxy-LSD (OH-LSD) in oral fluid samples using... 相似文献
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Albuloushi Asmaa Rhoten Megan Kelly Julie Sylvester Katelyn W. Grandoni Jessica Connors Jean M. 《Journal of thrombosis and thrombolysis》2022,54(4):597-604
Journal of Thrombosis and Thrombolysis - Historically, treatment of heparin-induced thrombocytopenia (HIT) includes a non-heparin parenteral anticoagulant with bridging to warfarin once platelets... 相似文献
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Kenta Matsuda Stephen A. Migueles Jinghe Huang Lyuba Bolkhovitinov Sarah Stuccio Trevor Griesman Alyssa A. Pullano Byong H Kang Elise Ishida Matthew Zimmerman Neena Kashyap Kelly M. Martins Daniel Stadlbauer Jessica Pederson Andy Patamawenu Nathaniel Wright Tulley Shofner Sean Evans C. Jason Liang Julin Candia Angelique Biancotto Giovanna Fantoni April Poole Jon Smith Jeff Alexander Marc Gurwith Florian Krammer Mark Connors 《The Journal of clinical investigation》2021,131(5)
BACKGROUNDTo understand the features of a replicating vaccine that might drive potent and durable immune responses to transgene-encoded antigens, we tested a replication-competent adenovirus type 4 encoding influenza virus H5 HA (Ad4-H5-Vtn) administered as an oral capsule or via tonsillar swab or nasal spray.METHODSViral shedding from the nose, mouth, and rectum was measured by PCR and culturing. H5-specific IgG and IgA antibodies were measured by bead array binding assays. Serum antibodies were measured by a pseudovirus entry inhibition, microneutralization, and HA inhibition assays.RESULTSAd4-H5-Vtn DNA was shed from most upper respiratory tract–immunized (URT-immunized) volunteers for 2 to 4 weeks, but cultured from only 60% of participants, with a median duration of 1 day. Ad4-H5-Vtn vaccination induced increases in H5-specific CD4+ and CD8+ T cells in the peripheral blood as well as increases in IgG and IgA in nasal, cervical, and rectal secretions. URT immunizations induced high levels of serum neutralizing antibodies (NAbs) against H5 that remained stable out to week 26. The duration of viral shedding correlated with the magnitude of the NAb response at week 26. Adverse events (AEs) were mild, and peak NAb titers were associated with overall AE frequency and duration. Serum NAb titers could be boosted to very high levels 2 to 5 years after Ad4-H5-Vtn vaccination with recombinant H5 or inactivated split H5N1 vaccine.CONCLUSIONReplicating Ad4 delivered to the URT caused prolonged exposure to antigen, drove durable systemic and mucosal immunity, and proved to be a promising platform for the induction of immunity against viral surface glycoprotein targets.TRIAL REGISTRATIONClinicalTrials.gov and NCT01443936.FUNDINGIntramural and Extramural Research Programs of the NIAID, NIH (U19 AI109946) and the Centers of Excellence for Influenza Research and Surveillance (CEIRS), NIAID, NIH (contract HHSN272201400008C). NCT01806909相似文献
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