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Tetsuji Terazawa Jin Matsuyama Masahiro Goto Ryohei Kawabata Shunji Endo Motohiro Imano Shoichiro Fujita Yusuke Akamaru Hirokazu Taniguchi Mitsutoshi Tatsumi Sang-Woong Lee Yoshitaka Kurisu Hisato Kawakami Yukinori Kurokawa Toshio Shimokawa Daisuke Sakai Takeshi Kato Kazumasa Fujitani Taroh Satoh 《The oncologist》2020,25(2):119-e208
3.
Kentaro Matsuo Kohei Taniguchi Hiroki Hamamoto Yosuke Inomata Kazumasa Komura Tomohito Tanaka Sang-Woong Lee Kazuhisa Uchiyama 《Cancer science》2021,112(8):2984-2992
Delta-like canonical Notch ligand 3 (DLL3) is a member of the Delta/Serrate/Lag2 (DSL) Notch receptor ligand family and plays a crucial role in Notch signaling, which influences various cellular processes including differentiation, proliferation, survival, and apoptosis. DLL3 is expressed throughout the presomitic mesoderm and is localized to the rostral somatic compartments; mutations in DLL3 induce skeletal abnormalities such as spondylocostal dysostosis. Recently, DLL3 has attracted interest as a novel molecular target due to its high expression in neuroendocrine carcinoma of the lung. Moreover, a DLL3-targeting Ab-drug conjugate, rovalpituzumab tesirine (ROVA-T), has been developed as a new treatment with proven antitumor activity. However, the development of ROVA-T was suspended because of shorter overall survival compared to topotecan, the second-line standard treatment. Thus, several studies on the mechanism and function of DLL3 in several malignancies are underway to find a new strategy for targeting DLL3. In this review, we discuss the roles of DLL3 in various malignancies and the future perspectives of DLL3-related research, especially as a therapeutic target. 相似文献
4.
Takashi Anayama Kentaro Hirohashi Ryohei Miyazaki Hironobu Okada Marino Yamamoto Kazumasa Orihashi 《The Journal of international medical research》2021,49(2)
ObjectiveTo determine the appropriate amount of indocyanine green for bronchial insufflation.MethodsWe enrolled 20 consecutive patients scheduled for anatomical segmentectomy in the Kochi Medical School Hospital. After inducing general anesthesia, 6 to 60 mL of 200-fold-diluted indocyanine green (0.0125 mg/mL) was insufflated into the subsegmental bronchi in the targeted pulmonary segmental bronchus. The volume of the targeted pulmonary segments was calculated using preoperative computed tomography. Fluorescence spread in the segmental alveoli was visualized using a dedicated near-infrared thoracoscope.ResultsThe targeted segment was uniformly visualized by indocyanine green fluorescence in 16/20 (80.0%) cases after insufflating indocyanine green. A receiver operating characteristic curve indicated that the area under the curve was 0.984; the optimal cut-off volume of diluted indocyanine green for insufflation was 8.91% of the calculated targeted pulmonary segment volume.ConclusionsThe setting for indocyanine green insufflation was optimized for near-infrared fluorescence image-guided anatomical segmentectomy. By injecting the correct amount of indocyanine green, fluorescence-guided anatomical segmentation may be performed more appropriately. 相似文献
5.
Incidence of urethral stricture after bipolar transurethral resection of the prostate using TURis: results from a randomised trial 下载免费PDF全文
6.
Eosinophilic granuloma of the ramus similar to malignant neoplasm or osteomyelitis: Report of a case
Tsuyoshi Sato D.D.S. D.D.Sc. Yasuhiko Morita D.D.S. Ryutaro Oku D.D.S. Prof. Takenori Noikura D.D.S. D.M.Sc. Hiroshi Mukai D.D.S. D.M.Sc. Kazumasa Sugihara D.D.S. D.M.Sc. Prof. Sukehide Yamashita M.D. D.D.S. D.M.Sc. Motoo Kitano D.D.S. D.M.Sc. 《Oral Radiology》1990,6(2):63-68
An eosinophilic granuloma was discovered in the region of the ramus of the mandible. This case occured in a very rare location
limited only to the ramus, and showed similar features resembling osteomyelitis or malignant neoplasm at different stages
of the disease. The radiographic findings indicated a diagnosis of malignant neoplasm and the scintigraphic manifestations
showed that of osteomyelitis. The histopathological examinations showed different manifestations in accordance with the respective
stages of the disease. This case was finally diagnosed as eosinophilic granuloma showing rapid regression. 相似文献
7.
Maeda A Soejima K Ogura M Ohmure H Sugihara K Miyawaki S 《The Angle orthodontist》2008,78(6):1125-1132
We performed an orthodontic treatment combined with mandibular distraction osteogenesis in a 15-year-old patient who wanted a correction of a chin deficiency and a protruding upper lip. The patient had an Angle Class II division 1 malocclusion with mandibular retrusion, a low mandibular plane angle, and scissors bite. First, a quad-helix appliance was applied to the mandibular dentition to correct the scissors bite in the bilateral premolar region. Later, a preadjusted edgewise appliance was applied to the maxillary and mandibular teeth. After 3 days, a mandibular distraction osteogenesis was performed. During and after the distraction, the open bite between the upper and lower dental arches was corrected using up and down elastics. The total treatment time with the edgewise appliance was 14 months. A skeletal Class I apical base relationship, good facial profile, and optimum intercuspation of the teeth were achieved with the treatment. The jaw-movement pattern on the frontal view did not change during gum chewing. However, the maximum gap without pain increased. The electromyographic (EMG) activity of the masseter and anterior temporalis muscles, and maximum occlusal force increased. The present case report suggests that an orthodontic treatment combined with mandibular distraction osteogenesis in a patient with mandibular retrusion in the late growth period might be effective for improving stomatognathic function. 相似文献
8.
Fujitani Kazumasa Kurokawa Yukinori Takeno Atsushi Kawabata Ryohei Omori Takeshi Imamura Hiroshi Hirao Motohiro Endo Shunji Kawada Junji Moon Jeong Ho Kobayashi Noboru Takahashi Tsuyoshi Yamasaki Makoto Takiguchi Shuji Mori Masaki Eguchi Hidetoshi Doki Yuichiro 《Annals of surgical oncology》2022,29(2):933-934
Annals of Surgical Oncology - 相似文献
9.
Daisuke Gotoh MD PhD Nobutaka Shimizu MD PhD Naoki Wada MD PhD Katsumi Kadekawa MD PhD Tetsuichi Saito MD Shinsuke Mizoguchi MD PhD Yosuke Morizawa MD PhD Shunta Hori MD PhD Makito Miyake MD PhD Kazumasa Torimoto MD PhD William C. de Groat PhD Kiyohide Fujimoto MD PhD Naoki Yoshimura MD PhD 《Neurourology and urodynamics》2020,39(8):2120-2127