全文获取类型
收费全文 | 10849篇 |
免费 | 457篇 |
国内免费 | 43篇 |
专业分类
耳鼻咽喉 | 207篇 |
儿科学 | 213篇 |
妇产科学 | 159篇 |
基础医学 | 1434篇 |
口腔科学 | 293篇 |
临床医学 | 715篇 |
内科学 | 2490篇 |
皮肤病学 | 138篇 |
神经病学 | 914篇 |
特种医学 | 609篇 |
外科学 | 1731篇 |
综合类 | 57篇 |
预防医学 | 368篇 |
眼科学 | 235篇 |
药学 | 672篇 |
中国医学 | 26篇 |
肿瘤学 | 1088篇 |
出版年
2023年 | 56篇 |
2021年 | 133篇 |
2020年 | 111篇 |
2019年 | 144篇 |
2018年 | 174篇 |
2017年 | 153篇 |
2016年 | 168篇 |
2015年 | 147篇 |
2014年 | 204篇 |
2013年 | 268篇 |
2012年 | 499篇 |
2011年 | 548篇 |
2010年 | 294篇 |
2009年 | 264篇 |
2008年 | 416篇 |
2007年 | 456篇 |
2006年 | 512篇 |
2005年 | 507篇 |
2004年 | 502篇 |
2003年 | 466篇 |
2002年 | 491篇 |
2001年 | 406篇 |
2000年 | 452篇 |
1999年 | 401篇 |
1998年 | 146篇 |
1997年 | 129篇 |
1996年 | 108篇 |
1995年 | 125篇 |
1994年 | 85篇 |
1993年 | 72篇 |
1992年 | 222篇 |
1991年 | 252篇 |
1990年 | 252篇 |
1989年 | 251篇 |
1988年 | 241篇 |
1987年 | 235篇 |
1986年 | 204篇 |
1985年 | 177篇 |
1984年 | 142篇 |
1983年 | 101篇 |
1982年 | 47篇 |
1981年 | 48篇 |
1979年 | 90篇 |
1978年 | 42篇 |
1976年 | 45篇 |
1974年 | 40篇 |
1972年 | 61篇 |
1971年 | 44篇 |
1970年 | 46篇 |
1969年 | 57篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Ono Mayo Fukuda Izumi Nagao Mototsugu Tomiyama Keiko Okazaki-Hada Mikiko Shuto Yuki Kobayashi Shunsuke Yamaguchi Yuji Nagamine Tomoko Nakajima Yasushi Inagaki-Tanimura Kyoko Sugihara Hitoshi 《Pituitary》2022,25(4):615-621
Pituitary - Isolated adrenocorticotropic hormone deficiency is a rare disease; however, since immune check point inhibitors (ICIs) have become widely used, many more cases have been reported. In... 相似文献
2.
Matsumoto Kazuhisa Tobiume Takeshi Matsuura Tomomi Ise Takayuki Kusunose Kenya Yamaguchi Koji Yagi Shusuke Fukuda Daijyu Wakatsuki Tetsuzo Yamada Hirotsugu Soeki Takeshi Sata Masataka 《Journal of interventional cardiac electrophysiology》2022,63(2):417-424
Journal of Interventional Cardiac Electrophysiology - Previous studies examined the right atrial (RA) input site of the antegrade fast pathway (AFp) (AFpI). However, the left atrial (LA) input to... 相似文献
3.
Sumii Atsuhiko Hida Koya Sakai Yoshiharu Hoshino Nobuaki Nishizaki Daisuke Akagi Tomonori Fukuda Meiki Yamaguchi Tomohiro Takemasa Ichiro Tokunaga Takuya Watanabe Jun Watanabe Masahiko 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(7):1173-1179
International Journal of Clinical Oncology - Identifying lateral pelvic lymph node (LPN) metastasis in low rectal cancer is crucial before treatment. Several risk factors and prediction models for... 相似文献
4.
Fukuda Yosuke Nakao Shintaro Kaizu Yoshihiro Arima Mitsuru Shimokawa Sakurako Wada Iori Yamaguchi Muneo Takeda Atsunobu Sonoda Koh-Hei 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(11):3517-3523
Graefe's Archive for Clinical and Experimental Ophthalmology - To investigate the relevance of microaneurysm morphology in optical coherence tomography angiography (OCTA) image averaging and... 相似文献
5.
Harada Hideyuki Omori Shota Mori Keita Konno Masahiro Murakami Haruyasu Imagumbai Toshiyuki Fukuda Haruyuki Nakamatsu Kiyoshi Kimura Tomoki Tanabe Hiroaki Fujita Hideki Tatebe Hitoshi Fujitaka Kazunori Nishimura Yasumasa 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(6):1025-1033
International Journal of Clinical Oncology - This multi-institutional clinical trial evaluated the feasibility of intensity-modulated radiotherapy (IMRT) for patients with locally advanced... 相似文献
6.
7.
Takehiko Mori Souichi Shiratori Junji Suzumiya Mineo Kurokawa Motohiro Shindo Uchida Naoyuki Takenaka Katsuto Toshihiro Miyamoto Satoshi Morishige Makoto Hirokawa Takahiro Fukuda Yoshiko Atsuta Ritsuro Suzuki 《Hematological oncology》2020,38(3):266-271
Although allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to provide prolonged remission of relapsed/refractory mycosis fungoides (MF) and Sézary syndrome (SS), its role has not been fully evaluated. Here, the outcomes of allogeneic HSCT for patients with MF/SS were retrospectively evaluated by using the registry database of the Japan Society for Hematopoietic Cell Transplantation. Forty-eight patients were evaluable and enrolled in the analysis. Median age was 45.5 years. Eighteen patients (38%) received myeloablative conditioning, and 33 (69%) received HSCT from an alternative donor. Disease status was complete or partial response in 25% of the patients and relapsed or refractory in the others. At the time of analysis, 18 patients were alive, with a median follow-up of 31.0 months (range, 3.8-31.1). Three-year overall survival (OS) and progression-free survival (PFS) were 30% (95%CI, 16-45%) and 19% (95%CI, 9-31%), respectively. Disease progression was not observed later than 17 months after transplantation. Both disease status and performance status at transplant significantly affected OS and PFS. Although our findings suggest that allogeneic HSCT provides long-term PFS in patients with MF/SS, the timing of transplantation should be decided carefully based on the disease status and the patient's condition in order to improve the outcome. 相似文献
8.
Yawata Toshio Higashi Youichiro Kawanishi Yu Nakajo Takahito Fukui Naoki Fukuda Hitoshi Ueba Tetsuya 《Journal of neuro-oncology》2019,144(1):21-32
Journal of Neuro-Oncology - CD146 is highly expressed in various malignant tumors and contributes to their malignancy phenotype, which involves metastatic and tumorigenic activity. However, studies... 相似文献
9.
Higuchi Takashi Sugisawa Norihiko Yamamoto Jun Oshiro Hiromichi Han Qinghong Yamamoto Norio Hayashi Katsuhiro Kimura Hiroaki Miwa Shinji Igarashi Kentaro Tan Yuying Kuchipudi Shreya Bouvet Michael Singh Shree Ram Tsuchiya Hiroyuki Hoffman Robert M. 《Cancer chemotherapy and pharmacology》2020,85(2):285-291
Cancer Chemotherapy and Pharmacology - Cancers are methionine (MET) and methylation addicted, causing them to be highly sensitive to MET restriction. The present study determined the efficacy of... 相似文献
10.
Kenji Yamada Michinori Ito Hironori Kobayashi Yuki Hasegawa Seiji Fukuda Seiji Yamaguchi Takeshi Taketani 《Brain & development》2019,41(7):638-642
Multiple acyl-CoA dehydrogenase deficiency (MADD), also known as glutaric acidemia type II, is classically caused by a congenital defect in electron transfer flavoprotein (ETF) or ETF dehydrogenase (ETFDH). Flavin adenine dinucleotide synthase (FADS) deficiency caused by mutations in FLAD1 was recently reported as a novel riboflavin metabolism disorder resembling MADD. Here, we describe a Japanese boy with FADS deficiency due to a novel mutation (p.R249*) in FLAD1. In the asymptomatic male infant born at full term, newborn screening showed positive results with elevated C5 and C14:1 acylcarnitine levels and an increased C14:1/C2 ratio. Biochemical studies were unremarkable except for lactic acidosis (pH 7.197, lactate 61 mg/dL). A diagnosis of MADD was suspected because of mild abnormalities of the acylcarnitine profile and apparent abnormalities of urinary organic acids, although mutations in the ETFA, ETFB, ETFDH, and riboflavin transporter genes (SLC52A1, SLC52A2, and SLC52A3) were not detected. Administration of riboflavin and L-carnitine was initiated at one month of age based on the diagnosis of “biochemical MADD” despite a lack of symptoms. Nevertheless, the acylcarnitine profile was not normalized. Symptoms resembling bulbar palsy, such as vocal cord paralysis and dyspnea with stridor, were present from 3 months of age. At 4 months of age, he became bedridden because of hypoxic-ischemic encephalopathy due to fulminant respiratory failure with aspiration pneumonia. At 2 years and 5 months of age, a homozygous c.745C > T (p.R249*) mutation in the FLAD1 gene was identified, confirming the diagnosis of FADS deficiency. His severe clinical course may be caused by this nonsense mutation associated with poor responsiveness to riboflavin. Persistent lactic acidosis and neuropathy, such as bulbar palsy, may be important for diagnosing FADS deficiency. Although the biochemical findings in FADS deficiency are similar to those in MADD, their clinical symptoms and severity may not be identical. 相似文献