全文获取类型
收费全文 | 161675篇 |
免费 | 11056篇 |
国内免费 | 767篇 |
专业分类
耳鼻咽喉 | 1477篇 |
儿科学 | 4052篇 |
妇产科学 | 2961篇 |
基础医学 | 21725篇 |
口腔科学 | 3836篇 |
临床医学 | 15983篇 |
内科学 | 34029篇 |
皮肤病学 | 3123篇 |
神经病学 | 15472篇 |
特种医学 | 6590篇 |
外国民族医学 | 6篇 |
外科学 | 24669篇 |
综合类 | 1957篇 |
一般理论 | 141篇 |
预防医学 | 11805篇 |
眼科学 | 3375篇 |
药学 | 11153篇 |
中国医学 | 277篇 |
肿瘤学 | 10867篇 |
出版年
2023年 | 814篇 |
2022年 | 520篇 |
2021年 | 2307篇 |
2020年 | 2072篇 |
2019年 | 2953篇 |
2018年 | 3634篇 |
2017年 | 2898篇 |
2016年 | 3220篇 |
2015年 | 3682篇 |
2014年 | 5320篇 |
2013年 | 7221篇 |
2012年 | 11139篇 |
2011年 | 11805篇 |
2010年 | 6648篇 |
2009年 | 6319篇 |
2008年 | 10721篇 |
2007年 | 11407篇 |
2006年 | 10846篇 |
2005年 | 11013篇 |
2004年 | 10427篇 |
2003年 | 9852篇 |
2002年 | 9240篇 |
2001年 | 1806篇 |
2000年 | 1477篇 |
1999年 | 1808篇 |
1998年 | 1892篇 |
1997年 | 1466篇 |
1996年 | 1219篇 |
1995年 | 1366篇 |
1994年 | 1212篇 |
1993年 | 1171篇 |
1992年 | 1062篇 |
1991年 | 1097篇 |
1990年 | 918篇 |
1989年 | 841篇 |
1988年 | 787篇 |
1987年 | 834篇 |
1986年 | 755篇 |
1985年 | 729篇 |
1984年 | 822篇 |
1983年 | 724篇 |
1982年 | 845篇 |
1981年 | 765篇 |
1980年 | 649篇 |
1979年 | 472篇 |
1978年 | 451篇 |
1977年 | 468篇 |
1976年 | 390篇 |
1975年 | 358篇 |
1974年 | 323篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Coates Laura C. Mease Philip Kronbergs Andris Helt Cameron Sandoval David Park So Young Combe Bernard Nash Peter Deodhar Atul 《Clinical rheumatology》2022,41(10):3035-3047
Clinical Rheumatology - To evaluate the three-year efficacy and safety of ixekizumab with and without concomitant conventional synthetic disease-modifying antirheumatic drug (csDMARD) use in... 相似文献
2.
Fyenbo Daniel Benjamin Sommer Anders Stephansen Charlotte Nørgaard Bjarne Linde Kronborg Mads Brix Kristensen Jens Gerdes Christian Jensen Henrik Kjærulf Jensen Jesper Møller Nielsen Jens Cosedis 《Journal of interventional cardiac electrophysiology》2022,64(3):783-792
Journal of Interventional Cardiac Electrophysiology - To evaluate the association between different right ventricular (RV) lead positions as assessed by cardiac computed tomography (CT) and... 相似文献
3.
Teoh Xin-Yi Zhang Bin Belton Peter Chan Siok-Yee Qi Sheng 《Pharmaceutical research》2022,39(6):1267-1279
Pharmaceutical Research - Semi-solid extrusion (SSE) 3D printing has potential pharmaceutical applications for producing personalised medicine. However, the effects of ink properties and drug... 相似文献
4.
Siegler Benedikt Hermann Oehler Beatrice Kranke Peter Weigand Markus Alexander 《Der Anaesthesist》2022,71(8):646-660
Die Anaesthesiologie - Der Postpunktionskopfschmerz („postdural puncture headache“, PDPH) zählt zu den wesentlichen Komplikationen der peripartalen neuroaxialen Analgesie. Als... 相似文献
5.
Matthias Knefel PhD Elisabeth L. Zeilinger PhD Simone Lubowitzki PhD Katharina Krammer MSc Matthias Unseld MD Rupert Bartsch MD Thorsten Fuereder MD Ulrich Jäger MD Barbara Kiesewetter MD Maria Krauth MD Markus Raderer MD Philipp B. Staber MD Peter Valent MD Alexander Gaiger MD 《Cancer》2023,129(21):3466-3475
Background
Survival in cancer patients is associated with a multitude of biological, social, and psychological factors. Although it is well established that all these factors add to overall mortality, it is not well understood how the predictive power of these parameters changes in a comprehensive model and over time.Methods
Patients who attended the authors’ outpatient clinic were invited to participate. The authors followed 5180 mixed cancer patients (51.1% female; mean age, 59.1 years [SD = 13.8]) for up to 16 years and analyzed biological (age, sex, cancer site, anemia), psychological (anxiety, depression), and social variables (marital status, education, employment status) potentially predicting overall survival in a Cox proportional hazards model.Results
The median survival time for the entire sample was 4.3 years (95% confidence interval, 4.0–4.7). The overall survival probabilities for 1 and 10 years were 76.8% and 38.0%, respectively. Following an empirical approach, the authors split the time interval into five periods: acute, subacute, short-term, medium-term, and long-term. A complex pattern of variables predicted overall survival differently in the five periods. Biological parameters were important throughout most of the time, social parameters were either time-independent predictors or tended to be more important in the longer term. Of the psychological parameters, only depression was a significant predictor and lost its predictive power in the long-term.Conclusions
The findings of this study allow the development of comprehensive patient-specific models of risk and resilience factors addressing biopsychosocial needs of cancer patients, paving the way for a personalized treatment plan that goes beyond biomedical cancer care. 相似文献6.
Yamada Shinichi Takahashi Shun Malchow Berend Papazova Irina Stöcklein Sophia Ertl-Wagner Birgit Papazov Boris Kumpf Ulrike Wobrock Thomas Keller-Varady Katriona Hasan Alkomiet Falkai Peter Wagner Elias Raabe Florian J. Keeser Daniel 《European archives of psychiatry and clinical neuroscience》2022,272(6):957-969
European Archives of Psychiatry and Clinical Neuroscience - Significant evidence links white matter (WM) microstructural abnormalities to cognitive impairment in schizophrenia (SZ), but the... 相似文献
7.
8.
9.
Peter A. Bretscher 《Scandinavian journal of immunology》2022,95(1):e13110
The widely accepted Cytokine Milieu Hypothesis proposes that the cytokine milieu, in which antigen activates CD4 T cells, from a non-T cell source, primarily determines the Th subset to which the ensuing effector Th cells belong. We focus on the generation of Th1 and Th2 cells. We briefly restate the grounds for the Threshold Hypothesis we favour for how the Th1/Th2 phenotype of a response is primarily determined: tentative and robust thresholds of antigen-mediated CD4 T cell interactions lead to the generation of Th1 and Th2 cells. The component antigens of pathogens are present in different amounts. It is expected, within the context of the threshold mechanism that, although there is often an initial predominance of Th1 or Th2 cells, some Th cells of the opposing type are initially generated. An initially somewhat heterogeneous Th response is known to become with time more ‘coherent’ in its Th1/Th2 phenotype. I propose The Cytokine Implementation Hypothesis as a mechanism for how coherence is achieved. Most cytokines made by Th cells of one subset tend to facilitate the further generation of Th cells of this subset and/or inhibit the generation of Th cells of opposing subsets, accounting for how coherence may be achieved. Many observations on which The Cytokine Milieu Hypothesis is based are accounted for by this alternative hypothesis. We outline predictions of the new hypothesis and discuss the importance of coherence of immune responses for their efficacy in protecting against foreign invaders. 相似文献
10.
Improving hyperpolarized 129Xe ADC mapping in pediatric and adult lungs with uncertainty propagation