全文获取类型
收费全文 | 1517篇 |
免费 | 141篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 58篇 |
妇产科学 | 51篇 |
基础医学 | 231篇 |
口腔科学 | 8篇 |
临床医学 | 172篇 |
内科学 | 249篇 |
皮肤病学 | 1篇 |
神经病学 | 208篇 |
特种医学 | 31篇 |
外科学 | 192篇 |
综合类 | 30篇 |
预防医学 | 251篇 |
眼科学 | 15篇 |
药学 | 98篇 |
中国医学 | 1篇 |
肿瘤学 | 53篇 |
出版年
2021年 | 14篇 |
2020年 | 12篇 |
2019年 | 14篇 |
2018年 | 19篇 |
2017年 | 17篇 |
2016年 | 12篇 |
2015年 | 17篇 |
2014年 | 28篇 |
2013年 | 49篇 |
2012年 | 53篇 |
2011年 | 67篇 |
2010年 | 33篇 |
2009年 | 35篇 |
2008年 | 52篇 |
2007年 | 59篇 |
2006年 | 47篇 |
2005年 | 61篇 |
2004年 | 55篇 |
2003年 | 57篇 |
2002年 | 49篇 |
2001年 | 51篇 |
2000年 | 57篇 |
1999年 | 54篇 |
1998年 | 15篇 |
1997年 | 16篇 |
1996年 | 19篇 |
1995年 | 15篇 |
1994年 | 11篇 |
1992年 | 29篇 |
1991年 | 48篇 |
1990年 | 38篇 |
1989年 | 40篇 |
1988年 | 36篇 |
1987年 | 29篇 |
1986年 | 37篇 |
1985年 | 33篇 |
1984年 | 23篇 |
1983年 | 23篇 |
1982年 | 24篇 |
1981年 | 12篇 |
1980年 | 16篇 |
1979年 | 24篇 |
1978年 | 16篇 |
1977年 | 12篇 |
1974年 | 17篇 |
1973年 | 23篇 |
1972年 | 18篇 |
1971年 | 12篇 |
1969年 | 11篇 |
1966年 | 9篇 |
排序方式: 共有1658条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
S R Mordekar P Guthrie J R Bonham S E Olpin I Hargreaves P S Baxter 《European journal of paediatric neurology》2006,10(2):78-82
BACKGROUND: Mitochondrial diseases are an important group of neurometabolic disorders in children with varied clinical presentations and diagnosis that can be difficult to confirm. AIM: To report the significance of reduced respiratory chain enzyme (RCE) activity in muscle biopsy samples from children. METHODS: Retrospective odds ratio was used to compare clinical and biochemical features, DNA studies, neuroimaging, and muscle biopsies in 18 children with and 48 without reduced RCE activity. RESULTS: Children with reduced RCE activity were significantly more likely to have consanguineous parents, to present with acute encephalopathy and lactic acidaemia and/or within the first year of life; to have an axonal neuropathy, CSF lactate >4 mmol/l; and/or to have signal change in the basal ganglia. There were positive associations with a maternal family history of possible mitochondrial cytopathy; a presentation with failure to thrive and lactic acidaemia, ragged red fibres, reduced fibroblast fatty acid oxidation and with an abnormal allopurinol loading test. There was no association with ophthalmic abnormalities, deafness, epilepsy or myopathy. CONCLUSION: The association of these clinical, biochemical and radiological features with reduced RCE activity suggests a possible causative link. 相似文献
5.
6.
Recombinant erythropoietin improves exercise capacity in anemic hemodialysis patients 总被引:5,自引:0,他引:5
H T Robertson N R Haley M Guthrie D Cardenas J W Eschbach J W Adamson 《American journal of kidney diseases》1990,15(4):325-332
The objective of this study was to quantitate the improvement in exercise capacity produced in anemic chronic hemodialysis (HD) patients after correction of their anemia with recombinant human erythropoietin (rHuEPO). The maximal exercise capacity and quadriceps strength of 19 anemic HD patients was tested before and after correction of the anemia with rHuEPO. A progressive work exercise protocol (PWET) on a cycle ergometer was used to compare measurements of maximal oxygen uptake (VO2max), maximal heart rate, and subjective assessment of fatigue during the test. Measurements of quadriceps strength were performed before the cycle ergometer studies. At baseline, all patients had reduced VO2max (15.3 +/- 5.4 mL/kg/min) and maximal exercise heart rates (138.5 +/- 23.9 beats/min). rHuEPO increased the mean hematocrit from 21.2% to 35%, and this was associated with a 17% increase (P less than 0.0005) in the VO2max. At any specified work load, rHuEPO treatment decreased heart rate, minute ventilation, and the subjective perception of fatigue. Both isometric and isokinetic measurements of quadriceps strength were improved following administration of rHuEPO. The maximal exercise heart rate was decreased in comparison to the baseline measurements (P less than 0.04), suggesting that in contrast to normal subjects, HD patients stop exercise before oxygen transport limitations are reached. In this unselected group of chronic HD patients, rHuEPO produced clinically significant improvements in both aerobic exercise capacity and isometric and isokinetic quadriceps strength. The improvement in aerobic capacity was substantially less than would have been expected from the correction of a comparable degree of anemia in non-HD patients. None of the 19 treated patients attained the exercise performance level predicted for a sedentary normal subject. 相似文献
7.
M. S. Levine A. M. Adinolfi R. S. Fisher C. D. Hull D. Guthrie N. A. Buchwald 《Brain research》1988,440(2):267-279
These studies provide information on the changes in the ultrastructure in the caudate nucleus of aged cats. The major findings was that there was a decrease in the density of synapses in caudate neuropil. This decrease occurred in animals after 3 years of age and remained relatively constant in older animals. In conjunction with this change a population of unusually long synapses also occurred. These larger synaptic appositions were associated with enlarged spine heads. The caudate also showed a number of qualitative ultrastructural alterations. Many neurons contained accumulations of lipofuscin or lipopigment granules in aged animals. These inclusions occurred in both soma and dendrites of neurons and all types of glial cells. A unique configuration of collapsed agranular cisterns also was observed in aged animals. The present results indicate that decreases in synaptic density may by one morphological event underlying functional alterations observed in caudate neurons in aged cats. 相似文献
8.
J L McKimm-Breschkin J B Caldwell R E Guthrie A A Kortt 《Journal of virological methods》1991,32(1):121-124
A rapid new method for the purification of neuraminidase (NA) heads from influenza A virus is described. Virus was pelleted directly from allantoic fluid and was digested with pronase. The cores were removed by centrifugation, redigested and the released NA heads were pooled and concentrated. The NA was separated from all contaminating proteins in a single step on a Superose 12 column. The purified material was suitable for both crystallography and for the production of monospecific antisera. 相似文献
9.
10.
Jack pine (Pinus banksiana Lamb.) retain their seeds from year to year, so that in an irradiated forest, each tree receives a specific dose rate but has seeds that have accumulated a range of total doses. The Field Irradiator-Gamma facility in Pinawa, Manitoba, contains jack pine that have been irradiated longer and at lower dose rates than previously reported. Seed germination and germination rate were examined on seeds irradiated on the parent tree for up to 5 years. Germination rate was most sensitive and showed deleterious effects at 1.1 mGy hr-1. This is not much lower than results reported by others in shorter-term studies. Effects were related to dose rate rather than total dose. Hormesis, indicated by statistically significant increased germination rate, was evident at 0.6 mGy hr-1. To put these results into context, the concentrations of selected radionuclides that, through internal contamination, would deliver 1.1 mGy hr-1 to plants were estimated. For 99Tc and 129I, these concentrations are far above the chemical toxicity thresholds for plants. Clearly, as assessments of waste repositories begin to consider effects on organisms other than humans, such as plants, chemical toxicity will be an important feature. 相似文献