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1.
Andrea Ronchi MD Marco Montella MD Federica Zito Marino BD PhD Giuseppe Argenziano MD PhD Elvira Moscarella MD Gabriella Brancaccio MD Giuseppe Ferraro MD Giovanni Francesco Nicoletti MD Teresa Troiani MD Renato Franco MD PhD Immacolata Cozzolino MD PhD 《Cancer cytopathology》2022,130(1):18-29
Malignant melanoma (MM) is a highly aggressive neoplasm with a growing worldwide incidence. It is not uncommon that the disease is already metastatic at the time of the first diagnosis. Regional lymph nodes and skin are the first and most common metastatic sites, followed by distant visceral sites (lungs, liver, and central nervous system) and bone. In this clinical setting, fine-needle aspiration (FNA) often represents the first diagnostic approach. FNA is a useful tool to obtain a rapid and accurate diagnosis, in conjunction with ancillary techniques and molecular analysis, as recommended by recent guidelines. The aim of this review was to describe the cytomorphology, immunocytochemical tools, and molecular tools used for the diagnosis of MM metastases on FNA. 相似文献
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Cozzi Mariano Monteduro Davide Parrulli Salvatore Ristoldo Federica Corvi Federico Zicarelli Federico Staurenghi Giovanni Invernizzi Alessandro 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(3):781-789
Graefe's Archive for Clinical and Experimental Ophthalmology - The purpose of this study was to investigate the structural variations of the hyporeflective pocket of fluid (prechoroidal cleft)... 相似文献
4.
Olivari Davide De Giorgio Daria Staszewsky Lidia Irene Fumagalli Francesca Boccardo Antonio Novelli Deborah Manfredi Martina Babini Giovanni Luciani Anita Ruggeri Laura Magliocca Aurora Zani Davide Danilo Masson Serge Belloli Angelo Pravettoni Davide Maiocchi Giuseppe Latini Roberto Ristagno Giuseppe 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2022,36(4):727-738
Cardiovascular Drugs and Therapy - Available animal models of acute heart failure (AHF) and their limitations are discussed herein. A novel and preclinically relevant porcine model of decompensated... 相似文献
5.
Merlino Giovanni Smeralda Carmelo Gigli Gian Luigi Lorenzut Simone Pez Sara Surcinelli Andrea Marini Alessandro Valente Mariarosaria 《Journal of thrombosis and thrombolysis》2021,51(3):789-797
Journal of Thrombosis and Thrombolysis - No study investigated the possible detrimental effect of stress hyperglycemia on patients affected acute ischemic stroke (AIS) undergoing intravenous... 相似文献
6.
Carlo Romano Settanni Gianluca Ianiro Francesca Romana Ponziani Stefano Bibb Jonathan Philip Segal Giovanni Cammarota Antonio Gasbarrini 《World journal of gastroenterology : WJG》2021,27(43):7433-7445
In December 2019 a novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), started spreading from Wuhan city of Chinese Hubei province and rapidly became a global pandemic. Clinical symptoms of the disease range from paucisymptomatic disease to a much more severe disease. Typical symptoms of the initial phase include fever and cough, with possible progression to acute respiratory distress syndrome. Gastrointestinal manifestations such as diarrhoea, vomiting and abdominal pain are reported in a considerable number of affected individuals and may be due to the SARS-CoV-2 tropism for the peptidase angiotensin receptor 2. The intestinal homeostasis and microenvironment appear to play a major role in the pathogenesis of COVID-19 and in the enhancement of the systemic inflammatory responses. Long-term consequences of COVID-19 include respiratory disturbances and other disabling manifestations, such as fatigue and psychological impairment. To date, there is a paucity of data on the gastrointestinal sequelae of SARS-CoV-2 infection. Since COVID-19 can directly or indirectly affect the gut physiology in different ways, it is plausible that functional bowel diseases may occur after the recovery because of potential pathophysiological alterations (dysbiosis, disruption of the intestinal barrier, mucosal microinflammation, post-infectious states, immune dysregulation and psychological stress). In this review we speculate that COVID-19 can trigger irritable bowel syndrome and we discuss the potential mechanisms. 相似文献
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Pasquale Vergara MD PhD Carlo Pignalberi MD Ennio C. Pisanò MD Giampiero Maglia MD Paolo Della Bella MD Gabriele Zanotto MD Saverio Iacopino MD Francesco Solimene MD Valeria Calvi MD Massimiliano Marini MD Massimo Giammaria MD Mauro Biffi MD Giovanni Rovaris MD Fabrizio Caravati MD Fabio Quartieri MD Antonio Curnis MD Antonio Rapacciuolo MD PhD Gaetano Senatore MD Stefano Pedretti MD Davide Saporito MD Antonio Dello Russo MD Vincenzo E. Santobuono MD PhD Patrizia Pepi MD Antonio Duca MD Matteo Baroni MD Giulio Falasconi MD Daniele Giacopelli MSc Alessio Gargaro MSc Antonio D'Onofrio MD 《Journal of cardiovascular electrophysiology》2021,32(9):2528-2535
9.
Nicola De Stefano Victor Navarro-Tableros Dorotea Roggio Alberto Calleri Federica Rigo Ezio David Alessandro Gambella Daniela Bassino Antonio Amoroso Damiano Patrono Giovanni Camussi Renato Romagnoli 《Transplant international》2021,34(9):1607-1617
Livers from donors after circulatory death (DCD) are a promising option to increase the donor pool, but their use is associated with higher complication rate and inferior graft survival. Normothermic machine perfusion (NMP) keeps the graft at 37°C, providing nutrients and oxygen supply. Human liver stem cell-derived extracellular vesicles (HLSC-EVs) are able to reduce liver injury and promote regeneration. We investigated the efficacy of a reconditioning strategy with HLSC-EVs in an experimental model of NMP. Following total hepatectomy, rat livers were divided into 4 groups: (i) healthy livers, (ii) warm ischemic livers (60 min of warm ischemia), (iii) warm ischemic livers treated with 5 × 108 HLSC-EVs/g-liver, and (iv) warm ischemic livers treated with a 25 × 108 HLSC-EVs/g-liver. NMP lasted 6 h and HLSC-EVs (Unicyte AG, Germany) were administered within the first 15 min. Compared to controls, HLSC-EV treatment significantly reduced transaminases release. Moreover, HLSC-EVs enhanced liver metabolism by promoting phosphate utilization and pH self-regulation. As compared to controls, the higher dose of HLSC-EV was associated with significantly higher bile production and lower intrahepatic resistance. Histologically, this group showed reduced necrosis and enhanced proliferation. In conclusion, HLSC-EV treatment during NMP was feasible and effective in reducing injury in a DCD model with prolonged warm ischemia. 相似文献
10.
Cannizzaro Delia Tropeano Maria Pia Milani Davide Spaggiari Riccardo Zaed Ismail Mancarella Cristina Lasio Giovanni Battista Fornari Maurizio Servadei Franco Cardia Andrea 《Neurosurgical review》2021,44(3):1217-1225
Neurosurgical Review - Chordoma is a rare slow-growing neoplastic bone lesion. However, they show an invasive local growth and high recurrence rate, leading to an overall survival rate of 65% at 5... 相似文献