全文获取类型
收费全文 | 5210篇 |
免费 | 313篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 162篇 |
妇产科学 | 82篇 |
基础医学 | 691篇 |
口腔科学 | 20篇 |
临床医学 | 510篇 |
内科学 | 1305篇 |
皮肤病学 | 36篇 |
神经病学 | 536篇 |
特种医学 | 158篇 |
外国民族医学 | 2篇 |
外科学 | 761篇 |
综合类 | 7篇 |
一般理论 | 6篇 |
预防医学 | 233篇 |
眼科学 | 233篇 |
药学 | 352篇 |
中国医学 | 10篇 |
肿瘤学 | 413篇 |
出版年
2023年 | 28篇 |
2022年 | 24篇 |
2021年 | 108篇 |
2020年 | 64篇 |
2019年 | 115篇 |
2018年 | 144篇 |
2017年 | 115篇 |
2016年 | 92篇 |
2015年 | 123篇 |
2014年 | 175篇 |
2013年 | 262篇 |
2012年 | 349篇 |
2011年 | 366篇 |
2010年 | 220篇 |
2009年 | 179篇 |
2008年 | 323篇 |
2007年 | 350篇 |
2006年 | 319篇 |
2005年 | 314篇 |
2004年 | 256篇 |
2003年 | 234篇 |
2002年 | 227篇 |
2001年 | 107篇 |
2000年 | 121篇 |
1999年 | 99篇 |
1998年 | 42篇 |
1997年 | 24篇 |
1996年 | 34篇 |
1995年 | 18篇 |
1994年 | 19篇 |
1992年 | 62篇 |
1991年 | 45篇 |
1990年 | 52篇 |
1989年 | 56篇 |
1988年 | 30篇 |
1987年 | 50篇 |
1986年 | 47篇 |
1985年 | 35篇 |
1984年 | 26篇 |
1983年 | 22篇 |
1979年 | 18篇 |
1975年 | 21篇 |
1974年 | 21篇 |
1972年 | 15篇 |
1971年 | 13篇 |
1970年 | 21篇 |
1969年 | 16篇 |
1967年 | 16篇 |
1966年 | 18篇 |
1965年 | 21篇 |
排序方式: 共有5552条查询结果,搜索用时 15 毫秒
1.
Anna Vaczlavik Lucas Bouys Florian Violon Gaetan Giannone Anne Jouinot Roberta Armignacco Isadora P. Cavalcante Annabel Berthon Eric Letouzé Patricia Vaduva Maxime Barat Fidéline Bonnet Karine Perlemoine Christopher Ribes Mathilde Sibony Marie-Odile North Stéphanie Espiard Philippe Emy Jérôme Bertherat 《Genetics in medicine》2022,24(2):374-383
PurposeThis study aimed to investigate the genetic cause of food-dependent Cushing syndrome (FDCS) observed in patients with primary bilateral macronodular adrenal hyperplasia (PBMAH) and adrenal ectopic expression of the glucose-dependent insulinotropic polypeptide receptor. Germline ARMC5 alterations have been reported in about 25% of PBMAH index cases but are absent in patients with FDCS.MethodsA multiomics analysis of PBMAH tissues from 36 patients treated by adrenalectomy was performed (RNA sequencing, single-nucleotide variant array, methylome, miRNome, exome sequencing).ResultsThe integrative analysis revealed 3 molecular groups with different clinical features, namely G1, comprising 16 patients with ARMC5 inactivating variants; G2, comprising 6 patients with FDCS with glucose-dependent insulinotropic polypeptide receptor ectopic expression; and G3, comprising 14 patients with a less severe phenotype. Exome sequencing revealed germline truncating variants of KDM1A in 5 G2 patients, constantly associated with a somatic loss of the KDM1A wild-type allele on 1p, leading to a loss of KDM1A expression both at messenger RNA and protein levels (P = 1.2 × 10–12 and P < .01, respectively). Subsequently, KDM1A pathogenic variants were identified in 4 of 4 additional index cases with FDCS.ConclusionKDM1A inactivation explains about 90% of FDCS PBMAH. Genetic screening for ARMC5 and KDM1A can now be offered for most PBMAH operated patients and their families, opening the way to earlier diagnosis and improved management. 相似文献
2.
Michaud Katarzyna Magnin Virginie Faouzi Mohamed Fracasso Tony Aguiar Diego Dedouit Fabrice Grabherr Silke 《International journal of legal medicine》2021,135(5):1829-1836
International Journal of Legal Medicine - Sudden cardiac death (SCD) related to atherosclerotic coronary artery disease (ACAD) resulting in myocardial infarction is the most prevalent cause of... 相似文献
3.
Thomas Klopstock MD Aleksandar Videnovic MD Almut Turid Bischoff MD Cecilia Bonnet MD Laura Cif MD Cynthia Comella MD Marta Correa-Vela MD Maria L. Escolar MD Jamie L. Fraser MD Victoria Gonzalez MD Neal Hermanowicz MD Robert Jech MD Hyder A. Jinnah MD Tomasz Kmiec MD Anthony Lang MD Maria J. Martí MD Saadet Mercimek-Andrews MD Migvis Monduy MD Graeme A.M. Nimmo MBBS Belen Perez-Dueñas MD Helle Cecilie Viekilde Pfeiffer MD Lluis Planellas MD Emmanuel Roze MD Nivedita Thakur MD Laura Tochen MD Nora Vanegas-Arroyave MD Giovanna Zorzi MD Colleen Burns PhD Feriandas Greblikas MD 《Movement disorders》2021,36(6):1342-1352
4.
5.
Marion Dehurtevent Lieven Robberecht Anthony Thuault Etienne Deveaux Anne Leriche Fabrice Petit Corentin Denis Jean-Christophe Hornez Pascal Béhin 《The Journal of prosthetic dentistry》2021,125(3):453-461
Statement of problemStereolithography (SLA) ceramic crown frameworks are suitable for clinical use, but the impact of SLA build orientation has not been identified.PurposeThe purpose of this in vitro study was to investigate the effect of 3 build orientations on the physical and mechanical properties and the microstructure of SLA alumina dental ceramics.Material and methodsThe physical and mechanical properties and microstructures of 3 different oriented SLA alumina ceramics (ZX, ZY, and XY) were evaluated by visual observation, hydrostatic weighing (n=10/group), Weibull analyses (n=30/group), scanning electron microscopy, 3-point flexural strength (n=30/group), fracture toughness (indentation, single-edge-V-notched-beam) (n=4/group), and Vickers hardness (n=15/group) testing. The hydrostatic weighing, 3-point flexural strength, fracture toughness, and Vickers hardness testing data were statistically analyzed (α=.05).ResultsThe minimum resting period of slurries between the polymerization of 2 layers was shorter for the ZY- and ZX-oriented specimens and increased with the layer surface. The density and Vickers hardness of the SLA-manufactured specimens were similar for all groups (P>.05). The 95% confidence intervals of the Weibull moduli of the ZX- and ZY-oriented specimens were higher than that of the XY-oriented specimens, with no overlap fraction. The ZY-oriented specimens displayed significantly higher 3-point flexural strength (P<.05) and fracture toughness as evaluated by the single-edge-V-notched-beam method than the ZX-oriented specimens (P<.05). They also displayed significantly higher 3-point flexural strength than the XY-oriented specimens (P<.05). The microstructural analysis showed that the texturing was heterogeneous and that the major axis of the large grains of alumina ran parallel to the orientation of the layers.ConclusionsThe ZY orientation produced a reliable dental ceramic by SLA, with the shortest general manufacturing time and the highest mechanical strength when the layers were perpendicular to the test load surface. 相似文献
6.
7.
8.
9.
Adrien Bouglé MD PhD Pierre Rocheteau PhD David Briand MS David Hardy PhD Franck Verdonk MD PhD Carlo Tremolada MD Mikael Hivelin MD PhD Fabrice Chrétien MD PhD 《Muscle & nerve》2019,60(3):328-335
Introduction: No etiologic therapy is available for Duchenne muscular dystrophy (DMD), but mesenchymal stem cells were shown to be effective in preclinical models of DMD. The objective of this study is to investigate the effect of microfragmented fat extracted on a murine model of DMD. Methods: Fat tissue was extracted from healthy human participants and injected IM into DMD mice. Histological analysis, cytokines, and force measurement were performed up to 4 weeks after injection. Results: Duchenne muscular dystrophy mice injected with microfragmented fat exhibited an improved muscle phenotype (decreased necrosis and fibrosis), a decrease of inflammatory cytokines, and increased strength. Discussion: Administration of microfragmented fat in key muscles may improve muscular phenotype in patients with DMD. Muscle Nerve, 2019 相似文献
10.
Alexis Hermida Vronique Fressart Francoise Hidden‐Lucet Erwan Donal Vincent Probst Jean‐Claude Deharo Philippe Chevalier Didier Klug Nicolas Mansencal Etienne Delacretaz Pierre Cosnay Patrice Scanu Fabrice Extramiana Dagmar I. Keller Stephanie Rouanet Philippe Charron Estelle Gandjbakhch 《European journal of heart failure》2019,21(6):792-800