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排序方式: 共有342条查询结果,搜索用时 15 毫秒
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Diamantis I. Tsilimigras MD Rittal Mehta MPH Alfredo Guglielmi MD Francesca Ratti MD Hugo P. Marques MD Olivier Soubrane MD Vincent Lam MD George A. Poultsides MD Irinel Popescu MD Sorin Alexandrescu MD Guillaume Martel MD Tom Hugh MD Luca Aldrighetti MD Itaru Endo MD PhD Timothy M. Pawlik MD MPH PhD FACS FRACS 《Journal of surgical oncology》2020,122(5):955-963
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Cardiovascular disease is the most frequent cause of death and disability in diabetes, and the morbidity and mortality for coronary artery disease (CAD) in this population is two to four times higher than in nondiabetic subjects. Traditional risk factors do not fully explain the level of cardiovascular risk, and coronary disease events are often silent in diabetic patients. Thus, research has recently focused on improving the risk assessment of an individual patient with new tools in an effort to better identify subjects at highest risk and in need of aggressive management. Cardiovascular imaging has proven very helpful in this regard. Traditional methods to assess CAD are based on detection of obstructive luminal disease responsible for myocardial ischemia. However, acute coronary syndromes often occur in the absence of luminal stenoses. Hence, the utilization of imaging methodologies to visualize atherosclerosis in its presymptomatic stages has received mounting attention in recent years. In this article, we review the current literature on the utility of traditional imaging modalities for obstructive CAD (nuclear and echocardiographic stress testing) as well as atherosclerosis plaque imaging with carotid intima-media thickness and coronary artery calcium for risk stratification of diabetic patients. 相似文献
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D. I. Tsilimigras D. Moris J. M. Hyer F. Bagante K. Sahara A. Moro A. Z. Paredes R. Mehta F. Ratti H. P. Marques S. Silva O. Soubrane V. Lam G. A. Poultsides I. Popescu S. Alexandrescu G. Martel A. Workneh A. Guglielmi T. Hugh L. Aldrighetti I. Endo K. Sasaki A. I. Rodarte F. N. Aucejo T. M. Pawlik 《The British journal of surgery》2020,107(7):854-864
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Viviana Pensato Cinzia Tiloca Lucia Corrado Cinzia Bertolin Valentina Sardone Roberto Del Bo Daniela Calini Jessica Mandrioli Giuseppe Lauria Letizia Mazzini Giorgia Querin Mauro Ceroni Roberto Cantello Stefania Corti Barbara Castellotti Giulia Soldà Stefano Duga Giacomo P. Comi Cristina Cereda Gianni Sorarù Sandra D’Alfonso Franco Taroni Christopher E. Shaw John E. Landers Nicola Ticozzi Antonia Ratti Cinzia Gellera Vincenzo Silani The SLAGEN Consortium 《Journal of neurology》2015,262(5):1376-1378
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Olfactory identification ability implicates the integrity of the orbitofrontal cortex (OFC). The fronto–striatal circuits including the OFC have been involved in the neuropathology of Obsessive Compulsive Disorder (OCD). However, only a few studies have examined olfactory function in patients with OCD. The Brief Smell Identification Test (B-SIT) and tests from the Cambridge Neuropsychological Automated Battery (CANTAB) were administered to 25 patients with OCD and to 21 healthy matched controls. OCD patients showed a significant impairment in olfactory identification ability as well as widely distributed cognitive deficits in visual memory, executive functions, attention, and response inhibition. The degree of behavioural impairment on motor impulsivity (prolonged response inhibition Stop-Signal Reaction Time) strongly correlated with the B-SIT score. Our study is the first to indicate a shared OFC pathological neural substrate underlying olfactory identification impairment, impulsivity, and OCD. Deficits in visual memory, executive functions and attention further indicate that regions outside of the orbitofronto–striatal loop may be involved in this disorder. Such results may help delineate the clinical complexity of OCD and support more targeted investigations and interventions. In this regard, research on the potential diagnostic utility of olfactory identification deficits in the assessment of OCD would certainly be useful. 相似文献
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