首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1595207篇
  免费   132428篇
  国内免费   2514篇
耳鼻咽喉   21636篇
儿科学   52936篇
妇产科学   46227篇
基础医学   226463篇
口腔科学   47201篇
临床医学   140106篇
内科学   312350篇
皮肤病学   34078篇
神经病学   129588篇
特种医学   64840篇
外国民族医学   479篇
外科学   243827篇
综合类   39835篇
一般理论   559篇
预防医学   122576篇
眼科学   36450篇
药学   121289篇
  2篇
中国医学   2879篇
肿瘤学   86828篇
  2018年   14664篇
  2016年   12859篇
  2015年   14991篇
  2014年   20742篇
  2013年   31514篇
  2012年   42863篇
  2011年   45069篇
  2010年   26461篇
  2009年   25408篇
  2008年   43295篇
  2007年   45556篇
  2006年   46320篇
  2005年   44996篇
  2004年   44390篇
  2003年   42365篇
  2002年   41506篇
  2001年   75752篇
  2000年   78314篇
  1999年   66103篇
  1998年   16759篇
  1997年   15406篇
  1996年   15337篇
  1995年   15977篇
  1994年   15031篇
  1993年   14203篇
  1992年   55476篇
  1991年   53852篇
  1990年   52617篇
  1989年   50864篇
  1988年   47248篇
  1987年   46605篇
  1986年   44317篇
  1985年   42884篇
  1984年   32042篇
  1983年   27580篇
  1982年   16141篇
  1981年   14421篇
  1980年   13540篇
  1979年   30495篇
  1978年   21065篇
  1977年   17725篇
  1976年   16641篇
  1975年   17517篇
  1974年   21454篇
  1973年   20664篇
  1972年   18839篇
  1971年   17759篇
  1970年   16291篇
  1969年   15265篇
  1968年   13970篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Modified-release opioids are often prescribed for the management of moderate to severe acute pain following total hip and knee arthroplasty, despite recommendations against their use due to increasing concerns regarding harm. The primary objective of this multicentre study was to examine the impact of modified-release opioid use on the incidence of opioid-related adverse events compared with immediate-release opioid use, among adult inpatients following total hip or knee arthroplasty. Data for total hip and knee arthroplasty inpatients receiving an opioid analgesic for postoperative analgesia during hospitalisation were collected from electronic medical records of three tertiary metropolitan hospitals in Australia. The primary outcome was the incidence of opioid-related adverse events during hospital admission. Patients who received modified with or without immediate-release opioids were matched to those receiving immediate-release opioids only (1:1) using nearest neighbour propensity score matching with patient and clinical characteristics as covariates. This included total opioid dose received. In the matched cohorts, patients given modified-release opioids (n = 347) experienced a higher incidence of opioid-related adverse events overall, compared with those given immediate-release opioids only (20.5%, 71/347 vs. 12.7%, 44/347; difference in proportions 7.8% [95%CI 2.3–13.3%]). Modified-release opioid use was associated with an increased risk of harm when used for acute pain during hospitalisation after total hip or knee arthroplasty.  相似文献   
3.
Pharmaceutical Chemistry Journal - Metformin hydrochloride is widely used to treat diabetes mellitus. This review presents its physical and chemical properties and discusses methods of analysis...  相似文献   
4.
Khadka  J.  Ratcliffe  J.  Hutchinson  C.  Cleland  J.  Mulhern  B.  Lancsar  E.  Milte  R. 《Quality of life research》2022,31(9):2849-2865
Quality of Life Research - To evaluate the construct (convergent and known group) validity of the Quality-of-Life-Aged Care Consumer (QOL-ACC), an older-person-specific quality-of-life measure...  相似文献   
5.
6.
7.
8.
9.
PurposeTRAPPC9 deficiency is an autosomal recessive disorder mainly associated with intellectual disability (ID), microcephaly, and obesity. Previously, TRAPPC9 deficiency has not been associated with biochemical abnormalities.MethodsExome sequencing was performed in 3 individuals with ID and dysmorphic features. N-Glycosylation analyses were performed in the patients’ blood samples to test for possible congenital disorder of glycosylation (CDG). TRAPPC9 gene, TRAPPC9 protein expression, and N-glycosylation markers were assessed in patient fibroblasts. Complementation with wild-type TRAPPC9 and immunofluorescence studies to assess TRAPPC9 expression and localization were performed. The metabolic consequences of TRAPPC9 deficiency were evaluated using tracer metabolomics.ResultsAll 3 patients carried biallelic missense variants in TRAPPC9 and presented with an N-glycosylation defect in blood, consistent with CDG type I. Extensive investigations in patient fibroblasts corroborated TRAPPC9 deficiency and an N-glycosylation defect. Tracer metabolomics revealed global metabolic changes with several affected glycosylation-related metabolites.ConclusionWe identified 3 TRAPPC9 deficient patients presenting with ID, dysmorphic features, and abnormal glycosylation. On the basis of our findings, we propose that TRAPPC9 deficiency could lead to a CDG (TRAPPC9-CDG). The finding of abnormal glycosylation in these patients is highly relevant for diagnosis, further elucidation of the pathophysiology, and management of the disease.  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号