Verbesserte Qualität gelagerter Erythrozytenkonzentrate durch maschinelle Autotransfusion

Die Anaesthesiologie - Die Transfusion von Erythrozytenkonzentraten (EK) ist mit verschiedenen Nebenwirkungen assoziiert, die u. a. durch Lagerungsschäden an Erythrozyten hervorgerufen...     

Digitalisierung und künstliche Intelligenz in Orthopädie und Unfallchirurgie

In the course of digitalization it is becoming increasingly rare for medical documents to be handwritten. As a result, digitalization has already become an integral part of routine patient care but in contrast to other specialist disciplines, such as radiology or laboratory medicine, orthopedics and trauma surgery are still at the beginning of new technologies. Artificial intelligence is not only used in the form of surgical robots in joint surgery or in the design of individualized implants but also provides valuable decision-making aids through appropriate algorithms for diagnosis and treatment. It can be assumed that these technologies will be further developed and used increasingly more in the coming years. Typical examples are intuitively operable and autonomously working programs and systems that support the networking and work of medical personnel and make processes inside and outside inpatient care more precise and less vulnerable to disturbances.     

Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis

Background

Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF.

One time quantitative PCR detection of Pseudomonas aeruginosa to discriminate intermittent from chronic infection in cystic fibrosis

Background

Chronic airway infection with Pseudomonas aeruginosa is a major risk factor of progression of lung disease in patients with cystic fibrosis (CF). Chronic P. aeruginosa infection evolves from intermittent infection that is amenable to antibiotic eradication, whereas chronically adapted P. aeruginosa becomes resistant to antibiotic therapy. Discrimination of intermittent versus chronic infection is therefore of high therapeutic relevance, yet the available diagnostic methods are only partly satisfactory. The aim of the present study was, therefore, to evaluate the usage of quantitative PCR (qPCR) to measure pathogen abundance and to discriminate between intermittent and chronic Pseudomonas infection in patients with CF.

Clinical and radiological outcomes using the LIMA SMR stemless implant—A 2-year follow-up in 49 patients

BackgroundSince the introduction of stemless anatomic total shoulder arthroplasty (TSA), many studies have been published on this specific group of TSA implants. The following study aimed to evaluate clinical and radiological short- to mid-term outcomes of the LIMA SMR stemless anatomical implant.MethodsWe prospectively evaluated the outcome of 53 TSAs in 52 patients, with a mean age of 58.45 years (range 47-78 years) at the time of implantation with a minimum follow-up of 2 years (range 24-47 months). All patients were physically and radiologically examined; the results were documented by the Constant-Murley Score and the Simple Shoulder Value.ResultsSignificant improvements from preoperative to latest follow-up were documented in Constant-Murley Score (29.0-75.84 pts; P < .001), active range of motion (abduction 84.7°-133.2°, flexion 95.3°-146.4°, and external rotation 12.7°-32.4°). The mean Simple Shoulder Value was 82.15% at the last follow-up. There was no complete loosening of the humeral component, but a lowering of bone mineral density (radiolucencies, RLL) was observed in anteroposterior or axially views—radiographs at the humeral component in 10.2% of the cases, most of them on the anteroposterior view at the calcar region. There was no statistical difference in the outcome of the patients with RLL compared with the ones without radiolucencies. Major complications or revisions did not occur.ConclusionThis study provides comparable improvement in functional, radiographic, and subjective mid-term results with other stemless anatomic implants.     

Maximized song learning of juvenile male zebra finches following BDNF expression in the HVC

During song learning, vocal patterns are matched to an auditory memory acquired from a tutor, a process involving sensorimotor feedback. Song sensorimotor learning and song production of birds is controlled by a set of interconnected brain nuclei, the song control system. In male zebra finches, the beginning of the sensorimotor phase of song learning parallels an increase of the brain‐derived neurotrophic factor (BDNF) in just one part of the song control system, the forebrain nucleus HVC. We report here that transient BDNF‐mRNA upregulation in the HVC results in a maximized copying of song syllables. Each treated bird shows motor learning to an extent similar to that of the selected best learners among untreated zebra finches. Because this result was not found following BDNF overexpression in the target areas of HVC within the song system, HVC‐anchored mechanisms are limiting sensorimotor vocal learning.