Facile morphology control of 3D porous CeO2 for CO oxidation

3D porous CeO₂ with various morphologies was successfully synthesized via a facile precipitation using glycine as the soft bio-template. During the synthesis, it was demonstrated that the morphology of CeO₂ depended on the molar ratio of reactants. Furthermore, the catalytic performance towards CO oxidation of the as-synthesized CeO₂ with different morphologies was investigated. CeO₂ with a bowknot shape showed excellent catalytic performance, giving complete CO conversion at 370 °C, due to its properties of much higher oxygen vacancies, loosely packed pore structure and larger specific surface area.

Different morphologies of CeO₂ were obtained via a green and facial method, which realized CO complete conversion at 370 °C.     

Plant-Mediated Fabrication and Surface Enhanced Raman Property of Flower-Like Au@Pd Nanoparticles

The flower-like nanostructures of an Au core and Pd petals with the average size of 47.8 nm were fabricated through the successive reduction of HAuCl₄ and Na₂PdCl₄ at room temperature. During the synthesis, Cacumen Platycladi leaf extract served as weak reductant and capping agent. Characterization techniques such as Energy-dispersive X-ray spectroscopy, UV-Vis spectroscopy, and X-ray diffraction characterizations were employed to confirm that the as-synthesized nanoparticles have the structure of core-shell. The obtained core-shell nanoflowers exhibited good surface enhanced Raman spectroscopic activity with Rhodamine 6G.     

动态浊度法定量检测注射用氨苄西林钠中细菌内毒素含量

目的建立注射用氨苄西林钠中细菌内毒素含量的定量测定方法。方法采用稀释法排除氨苄西林钠对细菌内毒素含量测定的干扰。结果将注射用氨苄西林钠液稀释100倍,可排除其对细菌内毒素含量测定的干扰。结论使用动态浊度法检测注射用氨苄西林钠中的细菌内毒素含量是可行的,此方法可替代家兔热原检查法。     

TNF-α在高糖高胰岛素培养状态下对兔胸主动脉血管平滑肌细胞增殖的影响

目的：研究肿瘤坏死因子-α（TNF-α）对高糖高胰岛素状态下血管平滑肌细胞（VSMC）增殖的影响及其可能机制。方法：采用正常和高糖高胰岛素两种培养基培养兔胸主动脉平滑肌细胞，用四唑盐比色法（MTT法）测定细胞增殖。Griess试剂法测定细胞培养液中NO含量．一氧化氮合酶（NOS）试剂盒法测定NOS活性。结果：在两种培养条件下L-NAME均能促进VSMC增殖。在正常培养条件下左旋精氨酸（L-Arg）、TNF-α不影响VSMC增殖。在高糖高胰岛素培养条件下L-Arg能抑制VSMC增殖。而TNF-α促进VSMC增殖。在高糖高胰岛素培养条件下VSMC的NOS活性及NO产量均低于常规培养。TNF-α增加NOS活性及NO产量，其作用可被L-NAME抑制。TNF-α对L-Arg及L-NAME的作用具有双向调节性。结论：TNF-α能加强L-Arg抑制VSMC增殖的作用，同时也协同L-NAME促进VSMC的增殖。TNF-α诱导VMSC增殖的作用可能与NO介导有关。     

开胸术后患者氧气射流雾化吸入方法的改进

目的 探讨改进开胸术后患者氧气射流雾化吸入的方法,以增进排痰的有效性.方法 将126例开胸术后患者按住院时间分为观察组和对照组各63例.对照组按常规方法行雾化吸入,观察组改进雾化吸入方法,即于吸气的第1秒患者以中、示指并拢堵住雾化气出气口,第2～3秒中、示指松开1条缝隙,待吸气毕手指并拢仍堵住出气口并移吸嘴于口外,缩唇呼气后似前吸气.均每次15～25 min.结果 观察组雾化吸入462例次,对照组448例次.观察组呼吸频率、吸入障碍程度、有效咳痰率、SpO2≥0.98例次及肺部感染率均显著优于对照组(P＜0.01,P＜0.05).结论 改进后的雾化吸入方法可显著提高排痰效果,有利于降低肺部感染率.     

医院药房固体制剂包装情况简析

医院固体制剂在药剂制剂中约占70%,常用的有片剂、胶囊剂、颗粒剂、滴丸等。其包装一般分为多剂量包装和单剂量包装[1]。笔者走访了多家医院和药店,认为包装应符合安全性、稳定性、经济性、有效性的要求。现试以我院常用的固体制剂为例,对目前固体制剂的包装情况作一简单分析。     

生物反馈疗法对胃镜下消化性溃疡复发率的影响

①目的探讨生物反馈疗法时胃镜（vidioendoscope）下消化性溃疡复发率的影响，评价心理治疗对消化性溃疡的价值。②方法将100例活动期／A（包括A1、A2）期胃溃疡患者随机分为A（常规治疗组）和B（生物反馈组）两组，分别治疗6周，这到瘢痕期／S（包括S1、S2）期者即停止任何治疗后，每月查胃镜1次，共观察1年，分别记录两组的复发例数及复发率。③结果1年内复发率，B组明显低于A组，两组之间比较，差异具有统计学意义（P〈0．05）。④结论心理因素与消化性溃疡的关系不容忽视，重视心理治疗，可以有效地降低消化性溃疡的复发率，更好地改善溃疡的愈合质量。     

重用丹参冻干对胃镜下胃溃疡愈合时间和复发率的影响

①目的探讨重用加强胃肠道黏膜防卫功能药物丹参冻干对胃镜下胃溃疡愈合时间和复发率的影响。②方法将220例活动期(包括A1、A2)期胃溃疡患者随机分为丹参冻干联用奥美拉唑治疗观察组与单用奥美拉唑治疗对照组,每周胃镜检查1次,记录每例患者愈合时间。③结果平均愈合时间/A~S期平均时间组明显短于对照组,两组之间比较,差异有统计学意义(P<0.05);6个月后的胃溃疡复发率,观察组明显低于对照组,两组之间比较,差异有统计学意义(P<0.05)。④结论改变传统观念,重视加强胃肠道黏膜防卫功能,可有效地缩短胃溃疡的愈合时间、降低胃溃疡的近期复发率,可以更快、更好地愈合溃疡。     

HPLC测定氯唑沙宗片的含量

目的:建立HPLC测定氯唑沙宗片的方法.方法:采用Hypersil BDS-C18(4.6 mm×200 mm,5 μm)色谱柱,流动相:甲醇-乙腈-水(40:20:40);柱温:24℃;检测波长:281nm;流速:1.0 ml/min.结果:氯唑沙宗进样量在0.080 4～0.804 4 μg范围内与峰面积呈良好的线性关系(r=0.999 7),平均回收率为99.99%,RSD=0.36%(n=6).结论:本方法简便、准确、重现性好.可用于该制剂的质量控制.     

The effect of lycopene on cytochrome P450 isoenzymes and P-glycoprotein by using human liver microsomes and Caco-2 cell monolayer model

Lycopene is widely used as a dietary supplement. However, the effects of lycopene on cytochrome P450 (CYP) enzymes or P-glycoprotein (P-gp) are not comprehensive. The present study was performed to investigate the effects of lycopene on the CYP enzymes and P-gp activity. A cocktail method was used to evaluate the activities of CYP3A4, CYP2C9, CYP2C19, CYP2D6 and CYP2E1. Caco-2 cell monolayer model was carried out to assay lycopene on P-gp activity. The results indicated that lycopene had a moderate inhibitory effect on CYP2E1, with IC50 value of 43.65?μM, whereas no inhibitory effects on CYP3A4, CYP2C19, CYP2D6 and CYP2E1, with IC50 values all over 100?μM. In addition, lycopene showed almost no inhibitory effect on rhodamine-123 efflux and uptake (p?>?.05), indicated no effects on P-gp activity. In conclusion, there should be required attention when lycopene are coadministered with other drugs that are metabolised by CYP2E1.