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Vassiliki A. Papadimitrakopoulou MD Ji-Youn Han MD PhD Myung-Ju Ahn MD PhD Suresh S. Ramalingam MD Angelo Delmonte MD PhD Te-Chun Hsia MD Janessa Laskin MD Sang-We Kim MD PhD Yong He MD Chun-Ming Tsai MD Toyoaki Hida MD PhD Makoto Maemondo MD PhD Terufumi Kato MD Suzanne Jenkins DPhil Sabina Patel PhD Xiangning Huang PhD Gianluca Laus MD Aleksandra Markovets PhD Kenneth S. Thress PhD Yi-Long Wu MD Tony Mok MD 《Cancer》2020,126(2):373-380
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Well‐being,health and fitness of children who use wheelchairs: Feasibility study protocol to develop child‐centred ‘keep‐fit’ exercise interventions 下载免费PDF全文
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Deep brain stimulation (DBS) is a successful treatment for patients with Parkinson's disease. In adaptive DBS, stimulation is titrated according to feedback about clinical state and underlying pathophysiology. This contrasts with conventional stimulation, which is fixed and continuous. In acute trials, adaptive stimulation matches the efficacy of conventional stimulation while delivering about half the electrical energy. The latter means potentially fewer side-effects. The next step is to determine the long-term efficacy, efficiency, and side-effect profile of adaptive stimulation, and chronic trials are currently being considered by the medical devices industry. However, there are several different approaches to adaptive DBS, and several possible limitations have been highlighted. Here we review the findings to date to ascertain how and who to stimulate in chronic trials designed to establish the long-term utility of adaptive DBS. © 2020 International Parkinson and Movement Disorder Society 相似文献
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Yoshio Okada PhD Sheraz Khan PhD Ashley Curran BS Banu Ahtam DPhil Matti S. Hämäläinen DSc Roger D. Traub MD Phillip L. Pearl MD 《Annals of neurology》2020,88(2):418-422
Neoplastic or dysplastic neuronal tissue in the brain stem and cerebellum can become epileptogenic in pediatric patients. However, it is unknown whether such tissue may transform intrinsic properties of the human cerebellum, making it capable of generating epileptic population activity. We noninvasively detected epileptiform signals unaveraged in a pediatric patient with epilepsy due to a tumor in the middle cerebellar peduncle. Analysis of generators of the signals revealed that the cerebellum ipsilateral and contralateral to the tumor was the dominant interictal spike generator and could initiate ictal activity, suggesting that human cerebellum may become capable of intrinsically generating epileptic activity. ANN NEUROL 2020;88:418–422. 相似文献
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Cultural animation in health research: An innovative methodology for patient and public involvement and engagement 下载免费PDF全文
Mihaela Kelemen BA PhD DPhil Emma Surman BSc PhD Lisa Dikomitis BA MA PhD 《Health expectations》2018,21(4):805-813