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Attenuation of N-Nitrosodiethylamine -Induced Hepatocellular Carcinoma by Piceatannol and/or Cisplatin: The Interplay between Nuclear Factor (Erythroid Derived 2)-like 2 and Redox Status 下载免费PDF全文
Omnia AM SalamaFatma SM MoawedEnas M MoustafaEman I Kandil 《Asian Pacific journal of cancer prevention》2022,23(11):3895-3903
Background: The natural compound’s alternative and complementary uses have increased hopes for hepatocellular cancer treatment (HCC). Objects: The goal of this study was to see if Piceatannol (PIC) in combination with cisplatin has a synergistic effect on N, N-nitrosodiethylamine (DEN)-induced HCC in rats. Methods: Tissue antioxidant enzymes, malondialdehyde (MDA), and nuclear factor erythroid 2 related factors 2 (Nrf2) and tumor necrosis factor α (TNF-α) gene expression were all measured. Nuclear Factor Kabba B (NF-κB) was also tested, as well as hepatic caspase 3 and NAD (P) H quinone oxidoreductase 1 (NQO1). Liver specimens were subjected to histopathological analysis. Results: When compared to the HCC group, piceatannol and/or cisplatin caused a significant improvement in liver function tests, as well as a significant modulation in Nrf2 gene expression and antioxidant enzyme activities, as well as a significant decrease in tissue MDA, TNF-α, NF-κB levels, NQO1 activity, and prompt and caspase-3 activities. When the PIC and/or cisplatin combination was compared to each of these compounds alone, the results were substantial. Conclusion: PIC in combination with cisplatin has been shown to have a synergistic anticancer impact through modulating Nrf2 and redox state. In addition, adding PIC to an HCC therapy plan that includes chemotherapeutic medicines may boost the efficacy of cisplatin while reducing its negative effects. 相似文献
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Marwan SM Al-Nimer 《World journal of diabetes》2022,13(5):417-419
Hyperandrogenism and hyperinsulinemia have resulted from dysfunction of the theca cell of the ovary and adipose tissue and each one potentiates the other in patients with androgen excess disorders e.g., polycystic ovary disease and idiopathic hirsutism. Possible external and/or internal triggers can produce such cellular dysfunction. There is evidence that sodium valproate acts as a trigger of cellular dysfunction and produces both hyperinsulinemia and hyperandrogenism. Therefore, the elimination of these triggers can help the patients to recover from hyperinsulinemia, insulin resistance and hyperandrogenism. 相似文献
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Niveditha Girimaji Sakthivel Murugan SM Ritambhra Nada Ashish Sharma Manish Rathi Harbir S. Kohli Krishna L. Gupta Raja Ramachandran 《Nephrology (Carlton, Vic.)》2020,25(6):497-501
Alport syndrome (AS) is an inherited disorder of basement membranes caused by mutations affecting specific proteins of the type IV collagen family, presenting with nephropathy and extrarenal manifestations such as sensorineural deafness and ocular anomalies. Ten percentage to 15% of the patients with AS have autosomal recessive (ARAS) due to mutation in either COL4A3 or COL4A4 gene. We report a novel mutation in the COL4A3 gene in an Indian family with ARAS. The above‐mentioned genetic anomaly was a missense variation in exon 26 of the COL4A3 gene (chr2:228137797G>A; c.1891G>A) that resulted in the amino acid substitution of Arginine for Glycine at codon 631 (p.Gly631Arg) that was present in the heterozygous state in the asymptomatic parents and homozygous state in the male offspring who presented with early‐onset end‐stage renal disease, lenticonus and hearing loss. The patient (male offspring) underwent successful renal transplantation with his mother as a donor. 相似文献
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Routine invasive versus selective invasive strategies for Non‐ST‐elevation acute coronary syndromes: An Updated meta‐analysis of randomized trials 下载免费PDF全文
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Long‐term outcomes with first‐ vs. second‐generation drug‐eluting stents in saphenous vein graft lesions 下载免费PDF全文
Nagendra R. Pokala BS Rohan V. Menon BS Siddharth M. Patel BS George Christopoulos MD Georgios E. Christakopoulos MD Anna P. Kotsia MD Bavana V. Rangan BDS MPH Michele Roesle RN Shuaib Abdullah MD Jerrold Grodin MD Dharam J. Kumbhani MD SM MRCP Jeffrey Hastings MD Subhash Banerjee MD Emmanouil S. Brilakis MD PhD 《Catheterization and cardiovascular interventions》2016,87(1):34-40