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排序方式: 共有3054条查询结果,搜索用时 15 毫秒
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Patricia Estefania Ayala Aguirre Anna Paola Strieder Matheus Lotto Thaís Marchini Oliveira Daniela Rios Agnes Ftima Pereira Cruvinel Thiago Cruvinel 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2020,30(1):27-34
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Iñaki Comino-Méndez Luis J Leandro-García Guillermo Montoya Lucía Inglada-Pérez Aguirre A. de Cubas María Currás-Freixes Carolyn Tysoe Louise Izatt Rocío Letón Álvaro Gómez-Graña Veronika Mancikova María Apellániz-Ruiz Massimo Mannelli Francesca Schiavi Judith Favier Anne-Paule Gimenez-Roqueplo Henri J. L. M. Timmers Giovanna Roncador Juan F. Garcia Cristina Rodríguez-Antona Mercedes Robledo Alberto Cascón 《Journal of molecular medicine (Berlin, Germany)》2015,93(11):1247-1255
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Josué Hernando MD DDS PhD Pablo Aguirre MD Antonio Aguilar-Salvatierra DDS PhD Ignacio Osoitz Leizaola-Cardesa DDS PhD Ainhoa Bidaguren MD Gerardo Gómez-Moreno DDS PhD 《Journal of surgical oncology》2020,121(2):244-248
The aim was to evaluate sentinel node detection capacity by means of a magnetic probe in 11 patients with oral squamous cell carcinoma at stages T1-T2 received submucosal injections of a superparamagnetic iron oxide contrast agent (SPIO). A magnetic probe was used for sentinel node biopsy. The use of SPIO and magnetic probes in the early stages of oral cancer may offer an alternative to conventional radioisotope techniques and/or elective neck dissection. 相似文献
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Ilkka Liikanen Colette Lauhan Sara Quon Kyla Omilusik Anthony T. Phan Laura Barcel Bartrolí Amir Ferry John Goulding Joyce Chen James P. Scott-Browne Jason T. Yustein Nicole E. Scharping Deborah A. Witherden Ananda W. Goldrath 《The Journal of clinical investigation》2021,131(7)
Adoptive T cell therapies (ACTs) hold great promise in cancer treatment, but low overall response rates in patients with solid tumors underscore remaining challenges in realizing the potential of this cellular immunotherapy approach. Promoting CD8+ T cell adaptation to tissue residency represents an underutilized but promising strategy to improve tumor-infiltrating lymphocyte (TIL) function. Here, we report that deletion of the HIF negative regulator von Hippel-Lindau (VHL) in CD8+ T cells induced HIF-1α/HIF-2α–dependent differentiation of tissue-resident memory–like (Trm-like) TILs in mouse models of malignancy. VHL-deficient TILs accumulated in tumors and exhibited a core Trm signature despite an exhaustion-associated phenotype, which led to retained polyfunctionality and response to αPD-1 immunotherapy, resulting in tumor eradication and protective tissue-resident memory. VHL deficiency similarly facilitated enhanced accumulation of chimeric antigen receptor (CAR) T cells with a Trm-like phenotype in tumors. Thus, HIF activity in CD8+ TILs promotes accumulation and antitumor activity, providing a new strategy to enhance the efficacy of ACTs. 相似文献
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Colette N. Miller Janice A. Dye Mette C. Schladweiler Judy H. Richards Allen D. Ledbetter Erica J. Stewart 《Inhalation toxicology》2018,30(4-5):178-186
Apelin has cardiopulmonary protective properties that promote vasodilation and maintenance of the endothelial barrier. While reductions in apelin have been identified as a contributor to various lung diseases, including pulmonary edema, its role in the effect of air pollutants has not been examined. Thus, in the current study, we sought to investigate if apelin is a downstream target of inhaled ozone and if such change in expression is related to altered DNA methylation in the lung. Male, Long-Evans rats were exposed to filtered air or 1.0?ppm ozone for 4?h. Ventilation changes were assessed using whole-body plethysmography immediately following exposure, and markers of pulmonary edema and inflammation were assessed in the bronchoaveolar lavage (BAL) fluid. The enzymatic regulators of DNA methylation were measured in the lung, along with methylation and hydroxymethylation of the apelin promoter. Data showed that ozone exposure was associated with increased enhanced pause and protein leakage in the BAL fluid. Ozone exposure reduced DNA cytosine-5-methyltransferase (DNMT) activity and Dnmt3a/b gene expression. Exposure-induced upregulation of proliferating cell nuclear antigen, indicative of DNA damage, repair, and maintenance methylation. Increased methylation and reduced hydroxymethylation were measured on the apelin promoter. These epigenetic modifications accompanied ozone-induced reduction of apelin expression and development of pulmonary edema. In conclusion, epigenetic regulation, specifically increased methylation of the apelin promoter downstream of DNA damage, may lead to reductions in protective signaling of the apelinergic system, contributing to the pulmonary edema observed following the exposure to oxidant air pollution. 相似文献
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Julien Bollard Céline Patte Kristina Radkova Patrick Massoma Laurence Chardon Julie Valantin Nicolas Gadot Isabelle Goddard Cécile Vercherat Valérie Hervieu Géraldine Gouysse Gilles Poncet Jean-Yves Scoazec Thomas Walter Colette Roche 《The Journal of pathology》2019,249(3):343-355
The identification of novel regulators of tumor progression is a key challenge to gain knowledge on the biology of small intestinal neuroendocrine tumors (SI-NETs). We recently identified the loss of the axon guidance protein semaphorin 3F as a protumoral event in SI-NETs. Interestingly the expression of its receptor neuropilin-2 (NRP-2) was still maintained. This study aimed at deciphering the potential role of NRP-2 as a contributor to SI-NET progression. The role of NRP-2 in SI-NET progression was addressed using an approach integrating human tissue and serum samples, cell lines and in vivo models. Data obtained from human SI-NET tissues showed that membranous NRP-2 expression is present in a majority of tumors, and is correlated with invasion, metastatic abilities, and neovascularization. In addition, NRP-2 soluble isoform was found elevated in serum samples from metastatic patients. In preclinical mouse models of NET progression, NRP-2 silencing led to a sustained antitumor effect, partly driven by the downregulation of VEGFR2. In contrast, its ectopic expression conferred a gain of aggressiveness, driven by the activation of various oncogenic signaling pathways. Lastly, NRP-2 inhibition led to a decrease of tumor cell viability, and sensitized to therapeutic agents. Overall, our results point out NRP-2 as a potential therapeutic target for SI-NETs, and will foster the development of innovative strategies targeting this receptor. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献