全文获取类型
收费全文 | 101419篇 |
免费 | 4145篇 |
国内免费 | 247篇 |
专业分类
耳鼻咽喉 | 1457篇 |
儿科学 | 3110篇 |
妇产科学 | 2623篇 |
基础医学 | 13796篇 |
口腔科学 | 2631篇 |
临床医学 | 6180篇 |
内科学 | 23178篇 |
皮肤病学 | 2845篇 |
神经病学 | 7912篇 |
特种医学 | 2186篇 |
外国民族医学 | 3篇 |
外科学 | 12949篇 |
综合类 | 614篇 |
一般理论 | 25篇 |
预防医学 | 11468篇 |
眼科学 | 2255篇 |
药学 | 7607篇 |
中国医学 | 346篇 |
肿瘤学 | 4626篇 |
出版年
2023年 | 552篇 |
2022年 | 324篇 |
2021年 | 1611篇 |
2020年 | 860篇 |
2019年 | 1911篇 |
2018年 | 3333篇 |
2017年 | 1970篇 |
2016年 | 1907篇 |
2015年 | 2211篇 |
2014年 | 2372篇 |
2013年 | 3842篇 |
2012年 | 6489篇 |
2011年 | 6577篇 |
2010年 | 3375篇 |
2009年 | 2470篇 |
2008年 | 5474篇 |
2007年 | 5814篇 |
2006年 | 5696篇 |
2005年 | 5702篇 |
2004年 | 5273篇 |
2003年 | 4962篇 |
2002年 | 4667篇 |
2001年 | 3322篇 |
2000年 | 3477篇 |
1999年 | 2775篇 |
1998年 | 505篇 |
1996年 | 347篇 |
1992年 | 1344篇 |
1991年 | 1215篇 |
1990年 | 1161篇 |
1989年 | 1043篇 |
1988年 | 931篇 |
1987年 | 942篇 |
1986年 | 879篇 |
1985年 | 834篇 |
1984年 | 624篇 |
1983年 | 476篇 |
1979年 | 621篇 |
1978年 | 361篇 |
1976年 | 333篇 |
1975年 | 365篇 |
1974年 | 543篇 |
1973年 | 505篇 |
1972年 | 447篇 |
1971年 | 396篇 |
1970年 | 475篇 |
1969年 | 440篇 |
1968年 | 415篇 |
1967年 | 372篇 |
1966年 | 329篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Carlos Casas-Arozamena Cristian Pablo Moiola Ana Vilar Marta Bouso Juan Cueva Silvia Cabrera Victoria Sampayo Efigenia Arias Alicia Abalo Ángel García Ramón Manuel Lago-Lestón Sara Oltra Eva Díaz Juan Ruiz-Bañobre Rafael López-López Gema Moreno-Bueno Antonio Gil-Moreno Eva Colás Miguel Abal Laura Muinelo-Romay 《International journal of cancer. Journal international du cancer》2023,152(10):2206-2217
The analysis of mismatch repair proteins in solid tissue is the standard of care (SoC) for the microsatellite instability (MSI) characterization in endometrial cancer (EC). Uterine aspirates (UAs) or circulating-DNA (cfDNA) samples capture the intratumor heterogeneity and provide a more comprehensive and dynamic molecular diagnosis. Thus, MSI analysis by droplet-digital PCR (ddPCR) in UAs and cfDNA can provide a reliable tool to characterize and follow-up the disease. The UAs, paraffin-embedded tumor tissue (FFPE) and longitudinal plasma samples from a cohort of 90 EC patients were analyzed using ddPCR panel and compared to the SoC. A high concordance (96.67%) was obtained between the analysis of MSI markers in UAs and the SoC. Three discordant cases were validated as unstable by ddPCR on FFPE samples. Besides, a good overall concordance (70.27%) was obtained when comparing the performance of the ddPCR assay on UAs and cfDNA in high-risk tumors. Importantly, our results also evidenced the value of MSI analysis to monitor the disease evolution. MSI evaluation in minimally invasive samples shows great accuracy and sensitivity and provides a valuable tool for the molecular characterization and follow-up of endometrial tumors, opening new opportunities for personalized management of EC. 相似文献
2.
Eskandarifard Ebrahim Silva Rui Nobari Hadi Clemente Filipe Manuel Pérez-Gómez Jorge Figueiredo António José 《Sport Sciences for Health》2022,18(2):297-305
Sport Sciences for Health - The purposes of this study were to describe the fitness and hormonal levels according to playing time (PT) (i.e., PT during season less (PT1) or more (PT2) than 50% of... 相似文献
3.
Thomas Behrens Calvin Ge Roel Vermeulen Benjamin Kendzia Ann Olsson Joachim Schüz Hans Kromhout Beate Pesch Susan Peters Lützen Portengen Per Gustavsson Dario Mirabelli Pascal Guénel Danièle Luce Dario Consonni Neil E. Caporaso Maria Teresa Landi John K. Field Stefan Karrasch Heinz-Erich Wichmann Jack Siemiatycki Marie-Elise Parent Lorenzo Richiardi Lorenzo Simonato Karl-Heinz Jöckel Wolfgang Ahrens Hermann Pohlabeln Guillermo Fernández-Tardón David Zaridze John R. McLaughlin Paul A. Demers Beata Świątkowska Jolanta Lissowska Tamás Pándics Eleonora Fabianova Dana Mates Vladimir Bencko Lenka Foretova Vladimír Janout Paolo Boffetta Bas Bueno-de-Mesquita Francesco Forastiere Kurt Straif Thomas Brüning 《International journal of cancer. Journal international du cancer》2023,152(4):645-660
There is limited evidence regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. We estimated lung-cancer risks in relation to quantitative indices of occupational exposure to Cr(VI) and nickel and their interaction with smoking habits. We pooled 14 case-control studies from Europe and Canada, including 16 901 lung-cancer cases and 20 965 control subjects. A measurement-based job-exposure-matrix estimated job-year-region specific exposure levels to Cr(VI) and nickel, which were linked to the subjects' occupational histories. Odds ratios (OR) and associated 95% confidence intervals (CI) were calculated by unconditional logistic regression, adjusting for study, age group, smoking habits and exposure to other occupational lung carcinogens. Due to their high correlation, we refrained from mutually adjusting for Cr(VI) and nickel independently. In men, ORs for the highest quartile of cumulative exposure to CR(VI) were 1.32 (95% CI 1.19-1.47) and 1.29 (95% CI 1.15-1.45) in relation to nickel. Analogous results among women were: 1.04 (95% CI 0.48-2.24) and 1.29 (95% CI 0.60-2.86), respectively. In men, excess lung-cancer risks due to occupational Cr(VI) and nickel exposure were also observed in each stratum of never, former and current smokers. Joint effects of Cr(VI) and nickel with smoking were in general greater than additive, but not different from multiplicative. In summary, relatively low cumulative levels of occupational exposure to Cr(VI) and nickel were associated with increased ORs for lung cancer, particularly in men. However, we cannot rule out a combined classical measurement and Berkson-type of error structure, which may cause differential bias of risk estimates. 相似文献
4.
Zrubka Zsombor Vékás Péter Németh Péter Dobos Ágota Hajdu Ottó Kovács Levente Gulácsi László Hibbard Judith Péntek Márta 《The European journal of health economics》2022,23(8):1341-1355
The European Journal of Health Economics - Patient activation comprises the skills, knowledge and motivation necessary for patients’ effective contribution to their care. We adapted and... 相似文献
5.
6.
7.
A.L. Ríos-López A.E. Bustamante G.M. González J.M. Llaca-Diaz A. Sánchez-González 《Indian journal of medical microbiology》2022,40(1):156-159
Cystic fibrosis is characterized by abnormal mucous secretions in the lungs that favor the proliferation of colonizing bacteria, with Pseudomonas aeruginosa and Staphylococcus aureus being the most isolated, however, other less known species could also have an impact on the health of the patient. Here we demonstrate the isolation and antibiotic resistance profiles of Inquilinus limosus, a rarely reported multidrug resistant bacterium, and compare them to a co-infectant strain of Pseudomonas aeruginosa. Likewise, we found that co-infection with both bacteria promotes increased formation of neutrophil extracellular traps, which can have an impact on the disease severity and make treatment difficult. 相似文献
8.
D’Antongiovanni Vanessa Pellegrini Carolina Benvenuti Laura Fornai Matteo Di Salvo Clelia Natale Gianfranco Ryskalin Larisa Bertani Lorenzo Lucarini Elena Di Cesare Mannelli Lorenzo Ghelardini Carla Nemeth Zoltan H. Haskó György Antonioli Luca 《Inflammation》2022,45(4):1829-1847
Inflammation - The pharmacological blockade of P2X4 receptors has shown potential benefits in the management of several immune/inflammatory diseases. However, data regarding the involvement of P2X4... 相似文献
9.
Carlos Moctezuma-Velazquez Graciela Castro-Narro Pablo Simó Elisabet Viayna Susana Aceituno Maria Soler Aldo Torre 《Annals of hepatology》2022,27(2):100673
Introduction and objectivesLiver cirrhosis is a major public health issue associated with high morbidity and mortality. The ANSWER trial showed that long-term human albumin (LTA) infusions led to significant reduction of complications and mortality in patients with uncomplicated ascites. The present study aimed to assess the incremental cost of cirrhosis patients treated with LTA plus standard medical treatment (SMT) versus those treated with SMT from the perspective of the Mexican Social Security Institute (IMSS).Material and methodsCost of illness for patients with cirrhosis and grade 2-3 ascites treated with SMT or with SMT and LTA (following the treatment regimen from ANSWER) over a one-year period was estimated according to the IMSS perspective. Rates of treatments, complications and hospitalizations were based on results from the ANSWER trial. Unit costs from IMSS were gathered from public sources and transformed to 2020 Mexican $ (Mex$).ResultsThe use of LTA is estimated to require additional annual expenditure derived from the pharmacological cost of human albumin and by the follow up visits required for LTA administration (Mex$28,128). However, this cost may potentially be counterbalanced by the reduction in paracentesis, cirrhosis-related complications and hospitalizations which would lead to cost savings of Mex$33,417 per patient/year.ConclusionsBased on the ANSWER trial results, our study suggests that LTA may result in improved clinical outcomes and reduced costs for the IMSS when administered to cirrhosis patients with uncomplicated ascites. 相似文献
10.
Salinas-Rodríguez Aarón Sosa-Rubí Sandra G. Chivardi Carlos Rodríguez-Franco Roxana Gandhi Monica Mayer Kenneth H. Operario Don Gras-Allain Nathalie Vargas-Guadarrama Galileo Galárraga Omar 《AIDS and behavior》2022,26(3):833-842
AIDS and Behavior - Pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV but requires sustained adherence. Conditional economic incentives (CEIs) can improve medication-taking... 相似文献