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1.
Seuc Armando Humberto Fernandez-Gonzalez Lisbeth Mirabal Mayelin 《Zeitschrift fur Gesundheitswissenschaften》2022,30(3):665-673
Journal of Public Health - The Comparative Risk Assessment (CRA) framework comprehensively evaluates the impact of exposure to risk factors on health populations using the counterfactual causal... 相似文献
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Lara N. Roberts Ton Lisman Simon Stanworth Virginia Hernandez-Gea Maria Magnusson Armando Tripodi Jecko Thachil 《Journal of thrombosis and haemostasis》2022,20(1):39-47
Prolonged prothrombin time and thrombocytopenia are common in patients with cirrhosis. These parameters do not reflect the overall hemostatic rebalance or bleeding risk in the periprocedural setting; however, attempts to correct these parameters remain frequent. We review the literature on periprocedural bleeding risk, bleeding risk factors, and the risk and benefits of hemostatic interventions in patients with cirrhosis. We provide guidance recommendations on evaluating bleeding risk in this patient group and management of hemostatic abnormalities in the periprocedural setting. 相似文献
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Laura Albentosa-Gonzlez Nereida Jimenez de Oya Armando Arias Pilar Clemente-Casares Miguel ngel Martin-Acebes Juan Carlos Saiz Rosario Sabariegos Antonio Mas 《Viruses》2021,13(5)
Arthropod-borne flaviviruses, such as Zika virus (ZIKV), Usutu virus (USUV), and West Nile virus (WNV), are a growing cause of human illness and death around the world. Presently, no licensed antivirals to control them are available and, therefore, search for broad-spectrum antivirals, including host-directed compounds, is essential. The PI3K/Akt pathway controls essential cellular functions involved in cell metabolism and proliferation. Moreover, Akt has been found to participate in modulating replication in different viruses including the flaviviruses. In this work we studied the interaction of flavivirus NS5 polymerases with the cellular kinase Akt. In vitro NS5 phosphorylation experiments with Akt showed that flavivirus NS5 polymerases are phosphorylated and co-immunoprecipitate by Akt. Polymerase activity assays of Ala- and Glu-generated mutants for the Akt-phosphorylated residues also indicate that Glu mutants of ZIKV and USUV NS5s present a reduced primer-extension activity that was not observed in WNV mutants. Furthermore, treatment with Akt inhibitors (MK-2206, honokiol and ipatasertib) reduced USUV and ZIKV titers in cell culture but, except for honokiol, not WNV. All these findings suggest an important role for Akt in flavivirus replication although with specific differences among viruses and encourage further investigations to examine the PI3K/Akt/mTOR pathway as an antiviral potential target. 相似文献
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Luis Veloza Cristina Teixido Natalia Castrejon Fina Climent Ana Carri Marta Marginet Davide Soldini Blanca Gonzlez‐Farr Inmaculada Ribera‐Cortada Armando Lopez‐Guillermo Eva Gonzlez‐Barca Adriana Sierra Mileyka Herrera Cndida Gmez Adriana Garcia Olga Balagu Elias Campo Antonio Martinez 《Histopathology》2019,75(6):799-812
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Giulia Mattavelli PhD Alessia Gallucci BA Giandomenico Schiena MD Armando D'Agostino PhD MD Teresa Sassetti BA Stefano Bonora BA Sara Bertelli MD Alberto Benetti MD Elena Tugnoli BA Giovanni Maria Ruggiero MD Sandra Sassaroli MD Leonor Romero Lauro PhD Orsola Gambini PhD MD Costanza Papagno PhD MD 《The International journal of eating disorders》2019,52(5):576-581
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Felipe Barbieri Wohlgemuth Marília Bastos Quirino Brasil Armando Jos d'Acampora 《The breast journal》2019,25(5):932-937
Although breast implant‐associated anaplastic large cell lymphoma (BIA‐ALCL) is a rare disease, its incidence has been increasing. The aim of this study was to assess the risk of BIA‐ALCL in women with breast implants. A systematic search was carried out in Pubmed, Scopus, ScienceDirect, LIVIVO, Cochrane Library, Google Scholar, and OpenGrey databases. The risk assessment of bias was based on the Newcastle‐Ottawa Scale. The rarity of BIA‐ALCL was a major limitation. Although we have found evidence of an increased risk of BIA‐ALCL, further studies are needed to understand why some large samples did not present any case of the disease. 相似文献
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