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1.
Psychological mobile app for patients with acute myeloid leukemia: A pilot randomized clinical trial
Areej El-Jawahri MD Marlise R. Luskin MD Joseph A. Greer PhD Lara Traeger PhD Mitchell Lavoie BS Dagny Marie Vaughn BS Stephanie Andrews BS Daniel Yang BS Kofi Y. Boateng BS Richard A. Newcomb MD Nneka N. Ufere MD Amir T. Fathi MD Gabriela Hobbs MD Andrew Brunner MD Gregory A. Abel MD Richard M. Stone MD Daniel J. DeAngelo MD PhD Martha Wadleigh MD Jennifer S. Temel MD 《Cancer》2023,129(7):1075-1084
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Robert A. Smith PhD Kimberly S. Andrews BA Durado Brooks MD MPH Stacey A. Fedewa PhD MPH Deana Manassaram-Baptiste PhD MPH Debbie Saslow PhD Richard C. Wender MD 《CA: a cancer journal for clinicians》2019,69(3):184-210
Each year, the American Cancer Society publishes a summary of its guidelines for early cancer detection, data and trends in cancer screening rates, and select issues related to cancer screening. In this issue of the journal, the current American Cancer Society cancer screening guidelines are summarized, and the most current data from the National Health Interview Survey are provided on the utilization of cancer screening for men and women and on the adherence of men and women to multiple recommended screening tests. 相似文献
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Kayla Ann Andrews Joel S. Owen James McCarthy David Wesche Nathalie Gobeau Thaddeus H. Grasela Jrg J. Mhrle 《CTS Clinical and Translational Science》2021,14(2):712
Volunteer infection studies using the induced blood stage malaria (IBSM) model have been shown to facilitate antimalarial drug development. Such studies have traditionally been undertaken in single‐dose cohorts, as many as necessary to obtain the dose‐response relationship. To enhance ethical and logistic aspects of such studies, and to reduce the number of cohorts needed to establish the dose‐response relationship, we undertook a retrospective in silico analysis of previously accrued data to improve study design. A pharmacokinetic (PK)/pharmacodynamic (PD) model was developed from initial fictive‐cohort data for OZ439 (mixing the data of the three single‐dose cohorts as: n = 2 on 100 mg, 2 on 200 mg, and 4 on 500 mg). A three‐compartment model described OZ439 PKs. Net growth of parasites was modeled using a Gompertz function and drug‐induced parasite death using a Hill function. Parameter estimates for the PK and PD models were comparable for the multidose single‐cohort vs. the pooled analysis of all cohorts. Simulations based on the multidose single‐cohort design described the complete data from the original IBSM study. The novel design allows for the ascertainment of the PK/PD relationship early in the study, providing a basis for rational dose selection for subsequent cohorts and studies. Study Highlights
- WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC?
- WHAT QUESTION DID THIS STUDY ADDRESS?
- WHAT DOES THIS STUDY ADD TO OUR KNOWLEDGE?
- HOW MIGHT THIS CHANGE CLINICAL PHARMACOLOGY OR TRANSLATIONAL SCIENCE?
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Mei Yin Wong Katrina A. Andrews Benjamin G. Challis Soo‐Mi Park Carlo L. Acerini Eamonn R. Maher Ruth T. Casey 《Clinical endocrinology》2019,90(4):499-505
The succinate dehydrogenase (SDH) enzyme complex functions as a key enzyme coupling the oxidation of succinate to fumarate in the citric acid cycle. Inactivation of this enzyme complex results in the cellular accumulation of the oncometabolite succinate, which is postulated to be a key driver in tumorigenesis. Succinate accumulation inhibits 2‐oxoglutarate‐dependent dioxygenases, including DNA and histone demethylase enzymes and hypoxic gene response regulators. Biallelic inactivation (typically resulting from one inherited and one somatic event) at one of the four genes encoding the SDH complex (SDHA/B/C/D) is the most common cause for SDH deficient (dSDH) tumours. Germline mutations in the SDHx genes predispose to a spectrum of tumours including phaeochromocytoma and paraganglioma (PPGL), wild type gastrointestinal stromal tumours (wtGIST) and, less commonly, renal cell carcinoma and pituitary tumours. Furthermore, mutations in the SDHx genes, particularly SDHB, predispose to a higher risk of malignant PPGL, which is associated with a 5‐year mortality of 50%. There is general agreement that biochemical and imaging surveillance should be offered to asymptomatic carriers of SDHx gene mutations in the expectation that this will reduce the morbidity and mortality associated with dSDH tumours. However, there is no consensus on when and how surveillance should be performed in children and young adults. Here, we address the question: “What age should clinical, biochemical and radiological surveillance for PPGL be initiated in paediatric SDHx mutation carriers?”. 相似文献
6.
Rose Crossin Andrew J. Lawrence Zane B. Andrews Jhodie R. Duncan 《Addiction Research & Theory》2019,27(2):76-84
Background: Substance abuse can cause a range of harmful secondary health consequences, including body weight changes. These remain poorly understood but can lead to metabolic disorders including obesity and diabetes. Energy balance is a function of the equation: energy balance?=?energy intake – energy expenditure; an imbalance to this equation results in body weight changes. Currently, in the clinical setting, changes to food intake (energy intake) are considered as the primary mediator of body weight changes related to substance abuse, reflected in the current treatment focus on nutritional intervention. The influence of substance abuse on energy expenditure receives less attention. The aim of this think-piece is to consider potential causes of body weight changes during active substance abuse and abstinence, by focussing on the components of the energy balance equation.Methods: We discuss both human and animal studies on the effects of substance abuse on energy balance, with particular focus on animal models utilising pair-feeding, which enable investigation of energy balance whilst controlling for the effects of altered food intake.Results: We demonstrate that whilst some drugs of abuse affect food intake, this effect is inconsistent. Furthermore, body weight changes do not match food intake changes.Conclusion: We provide evidence that drugs of abuse can affect both energy intake and energy expenditure; contributing to the observed body weight changes. This think-piece highlights that treatment strategies for body weight changes related to substance abuse cannot focus solely on nutritional interventions, but should consider the impact of broader disruptions to energy balance. 相似文献
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ABSTRACTCollaborative ways of working have become increasingly important as healthcare adopts a more team-based approach to patient care. Interprofessional education (IPE) addresses some of the challenges associated with collaborative working and is increasingly offered to learners pre and post qualification. This article reports on a three-day IPE program designed to enable undergraduate health professional students develop interprofessional (IP) work readiness skills, knowledge, and values while undertaking clinical placement in a hospital setting. The curriculum built participant skills in culturally safe IP collaboration (IPC); focused on strategies for providing quality care to indigenous peoples and communities, and overtly linked IP competence to organizational mission and values. It highlighted the patient voice and displayed both the human cost of poor team communication and the comfort family members gained from watching united treating teams working with skill, compassion, and kindness. Twenty-four students from seven healthcare disciplines completed the program (N = 24). The Work Self-Efficacy Inventory (WS-Ei) and the Interprofessional Socialization and Valuing Scale (ISVS) assessed participant IP skills, knowledge, beliefs, values, attitudes, and confidence before and after program completion. A paired sample t-test showed an increase in mean scores in all responses on both scales. Results suggest that participation in the IPE program resulted in substantial shifts in knowledge, skills, and values as evidenced by changed assumptions and worldviews, enhanced knowledge and skills concerning IPC, improved understanding of other professional roles and increased confidence in managing workplace experiences. 相似文献
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D. Bella J. Culpepper J. Khaimova N. Ahmed Adam Belkalai I. Arroyo J. Andrews S. Gentle S. Emmanuel M. Lahmouh J. Ealy Zayna King O. Jenkins D. Fu Y. Choi G. Osterman J. Gruszczynski D. Skeete C. S. Blaszczak-Boxe 《Air quality, atmosphere, & health》2016,9(5):569-588
Transport of pollution from remote sources into the state of Texas has been shown by modeling techniques, satellite, and in situ data. Attaining a better understanding of the impact (i.e., temporally) of remote pollution sources will provide a more robust/quantifiable basis for State Implementation Plans (SIPs) that govern air quality. Utilizing Tropospheric Emission Spectrometer (TES) and Ozone Monitoring Instrument (OMI) and in situ data for ozone (O3) and nitrogen dioxide (NO2) and Hybrid Single-Particle Lagrangian Integrated Trajectory Model (HYSPLIT), we assess whether high-pollution events in Texas are primarily sourced locally (i.e., within Texas) or remotely. We focus on TES and OMI dates that exemplify high O3 and NO2, over Texas’s lower troposphere from August 5, 2006, to June 21, 2009. For all dates and altitudes, 4-day back trajectory analyses, exemplified by high TES O3, show that remotely sourced from the Gulf of Mexico, Southeast USA, Midwest USA, Northeast USA, the Atlantic Ocean, Pacific Ocean, Mexico to Texas. The only exception is air at 1 km on July 22, 2006, which shows that air at this altitude is sourced within Texas. Throughout half of the eastern portion of Texas, TES shows O3 enhancements in the boundary layer and OMI shows O3 and NO2 enhancements via tropospheric column profiles (O3 between 75 and 90 ppbv; NO2 ≥5.5 molecules cm?2). These enhancements complement the HYSPLIT 4-day trajectory analyses, which gives further indication that they are influenced by transport from remote sources. Dates with co-located satellite and in situ data (e.g., August 2, 2005) further exemplify the need to consider satellite and in situ data and modeling data/forecasts when creating SIPs for compliance with Environmental Protection Agency and the Texas Commission on Environmental Quality air quality standards. Despite the fact that quantifying local versus remote sources is in its early stages, Texas has become increasingly compliant with Environmental Protection Agency (EPA) regulations. Environmental Systems Research Institute’s ArcGIS exemplifies the noticeable decrease in the number of days that locales in Texas exceed EPA’s limit for O3. From 2005 to 2009, population standard deviation and standard error of the mean, and true sample deviation of the sample mean for O3 and NO2, at all 16 monitoring sites distributed throughout Texas, are temporally consistent and small—reinforcing the reliability of in situ data as they are consistent throughout. This investigation has global implications for regions within countries that enforce air quality mandates. Such governing bodies should consider utilizing data assimilation (of in situ data) for air quality prediction as a part of the governmental process that produces such laws. This could potentially keep regions more accountable for emissions both locally and far from high source points. 相似文献