经皮耳迷走神经刺激干预功能性消化不良模型大鼠的效应及机制研究

ObjectiveTo explore the effect and its possible mechanism of the intervention of transcutaneous auricular vagus nerve stimulation (taVNS) for the functional dyspepsia (FD) model rats.MethodsOf the 25 male SD rats, 6 rats were set as blank group, the other 19 rats were established to be the functional dyspepsia (FD) model by iodoacetamide intragastric administration, and 18 FD models were successfully established. The 18 model rats were randomly divided into a model group, a sham-taVNS group, and taVNS group, with 6 rats in each group. There was no intervention applied to the rats in the blank and model groups. Whereas, the rats in sham-taVNS group received stimulation to the rim of auricular concha of both sides, and those in taVNS group received stimulation to the cavity of auricular concha of both sides, for 30 min each time, once a day, 7 days in succession. After the intervention, the gastric sensitivity of the rats in each group under different pressure conditions in the stomach, the expressions of serum brain-gut peptide motilin (MTL), cholecystokinin (CCK), glucagon-likepeptide1 (GLP-1), and inflammatory factors IL-4, IL-10, and IL-1β were detected.Results(1) Gastric sensitivity: compared with the blank group, the gastric sensitivity of the model group was higher (P <0.05). Compared with the model group, the gastric sensitivity of the taVNS group was lower (P < 0.05). Compared with the sham-taVNS group, the gastric sensitivity of the taVNS group was lower (P <0.05).(2) Expression of brain-gut peptide: compared with the blank group, MTL was lower, CCK and GLP-1 were higher in the model group (all P <0.05). Compared with the model group, MTL was higher, CCK and GLP-1 were lower in the taVNS group (all P <0.05). Compared with the sham-taVNS group, CCK and GLP-1 were lower in the taVNS group (both P<0.05). (3)Expression of inflammatory factors: compared with the blank group, IL-4 and IL-10 were lower and IL-1β was higher in the model group (all P <0.05). Compared with the model group, IL-10 was higher and IL-1β was lower in the sham-taVNS group (all P <0.05), while IL-4 and IL-10 were higher and IL-1β was lower in the taVNS group (all P <0.05). Compared with the sham-taVNS group, IL-4 and IL-10 were higher and IL-1β was lower in the taVNS group (all P <0.05).ConclusionTaVNS can reduce the gastric sensitivity of FD model rats by peripheral anti-inflammatory action and regulating the abnormal secretion of brain-gut peptide.     

锁骨下静脉置管并发感染的预防

2001年1月至2003年12月，我们对180例患者行锁骨下静脉置管化疗，现将预防感染的体会报告如下。     

天晴甘平治疗脂肪性肝病的疗效观察

脂肪肝分为酒精性脂肪性肝病和非酒精性脂肪性肝病,近年来发病率呈明显上升趋势。我科应用甘草酸二铵肠溶胶囊(天晴甘平,江苏正大天晴药业)治疗(非)酒精性脂肪性肝病,以观察对该病的疗效。现将结果报告如下。1临床资料2004年5月~2005年6月,本院门诊及住院患者74例,随机分为治疗组和对照组。治疗组38例,3例未完成,合格35例,男25例,女10例,平均年龄(38.2±5.4)岁;对照组36例,4例未完成,合格32例,男23例,女9例,平均年龄(37.6±7.3)岁。全部病例均符合中华肝脏病学会脂肪肝和酒精性肝病学组制定的诊断标准[1]。全部病例均连续服药24周。观察治疗…     

肝细胞癌诊断中 CT 灌注成像的应用探析

目的：对肝细胞癌诊断中 CT 灌注成像的应用进行分析探讨,为今后的临床诊断工作提供可靠的参考依据。方法抽取在2011年1月至2014年10月我院收治的临床确诊肝细胞癌患者45例,对其在入院后与治疗后分别展开 CT 灌注成像,并对检查结果进行对比分析。结果经统计,治疗后患者肝脏血流量、肝脏血容量、肝动脉供血分数较治疗前发生显著降低（P ﹤0.05）,平均通过时间明显延长（P ﹤0.05）,感兴趣区肝动脉灌注值、门静脉灌注值和肝动脉灌注值均较治疗前发生明显降低（P ﹤0.05）。结论 CT 灌注成像能够对肝细胞癌血供情况进行反映,能够为肝细胞癌的临床诊断、预后评估提供可靠的参考依据,值得关注。     

L-丙氨酰-L-谷氨酰胺双肽对水痘合并脓毒症患者影响分析与护理

目的观察L-丙氨酰-L-谷氨酰胺双肽对水痘合并脓毒症患者炎症反应、免疫功能及临床转归的影响。方法将患者随机分为观察组和对照组,每组各25例。对照组患者每天提供普通氨基酸1.5 g/kg,观察组每天提供普通氨基酸1.0 g/kg和L-丙氨酰-L-谷氨酰胺双肽0.5 g/kg,肠外营养的各种成分配制成3 L袋在容量输液泵控制下匀速静脉输注,连用7 d。观察比较两组治疗前后炎症反应、免疫功能及临床结局等指标。结果观察组在治疗后第8天炎症反应、血清蛋白及免疫指标改善均较对照组明显;观察组病死率及ICU住院天数较对照组均降低,差异均有统计学意义（均P〈0.05）。结论 L-丙氨酰-L-谷氨酰胺双肽可改善脓毒症患者免疫功能、减轻炎症反应、降低病死率、缩短ICU住院日。     

全程信息化危急值管理系统在护理安全管理中的作用分析

目的探讨全程信息化危机值管理系统在护理安全管理中的作用。方法选择我院胸心外科2016年1月~2017年11月170例危急值报告,以2016年危急值报告数据为对照组,2017年全程信息化危急值管理系统持续改进应用后数据为试验组,比较两组危急值报告发出到通知临床护士时间、危急值报告发出到医生做出处理措施回复时间、危急值报告通知及时率(30min),临床医生在危急值系统做出处理措施回复及时率(30min),所有数据由系统记录客观准确。结果危急值报告发出到通知临床护士时间M(QR)由3.0(1.0)min缩减到2.0(1.0)min(P0.01)。危急值处理措施回复时间M(QR)由193(7.25)min缩减到7(3.0)min(P0.01)。结论全程信息化危急值管理系统的应用可以有效的监管危急值信息发生、传递、处理各个环节,有效的提高护理安全,确保护理质量,同时减少工作量,保障信息准确,提升患者、护士及医生对护理工作的满意度。     

两例原位肝移植病人生化指标分析

目的 了解肝移植患者的生化指标变化情况，是否与移植排斥有关。方法 收集肝移植患者术前、术中、术后的血液标本，用7170全自动生化分析仪、AVL电解质分析仪测定其结果。结果 两例不同年龄、不同病种患者的生化分析结果中ALT、TB、GGT单位变化有一定规律，出现术后的双峰现象。结论 肝移植患者出现ALT、TB、GGT术后两次高峰状况，可认为是患者肝移植后的排斥信号，应引起临床注意。     

抚触对导乐分娩新生儿身长及体重的影响

触感是人类最原始的感觉哭官,抚触是通过对婴儿皮肤感官的温和刺激,从而促进婴儿生长发育.作者通过对经导乐陪伴分娩的足月正常新生儿进行持续至42天的抚触后,观察其身长,体重重长情况,现报道如下.     

系统性红斑狼疮相关性再生障碍性贫血临床分析

系统性红斑狼疮(systemic lupus erythematosus,SLE)可累及全身各个器官系统,病程中可有血液系统异常,但合并再生障碍性贫血者少见,国内有个案报道,其发病机制不清.本研究诊治10例系统性红斑狼疮相关性再生障碍性贫血(SLE associated aplastic anemia,SLEAAA),与同期的慢性再生障碍性贫血(chronic aplastic anemia,CAA)通过检查其骨髓、T细胞亚群、造血祖细胞体外培养集落产率的差异,探讨其发病机制及治疗方法.     

结肠神经纤维瘤病一例

结肠神经纤维瘤病一例张冷月，王俊英，陈晓红，李世荣患者男，４０岁。２０余年来每天进食生冷瓜果及蔬菜后出现腹痛、腹泻，大便５～６次／日，稀便，无粘液及脓血。饮食改善后大便２～３次／日，成形或糊状便。曾以“急性阑尾炎”、“小肠不全梗阻”、“急性肠炎”在我...