乳腺癌组织中CacyBP/SIP的表达情况及临床病理意义

目的:探讨钙周期素结合蛋白(Cacy BP/SIP)在乳腺癌组织中的表达及临床病理意义。方法:应用免疫组织化学染色检测Cacy BP/SIP在86例乳腺癌组织、20例癌旁相对正常乳腺组织及16例乳腺腺病组织中的表达情况并分析临床病理意义。结果:免疫组织化学结果显示,在86例乳腺癌组织、20例癌旁组织、16例乳腺腺病组织中Cacy BP/SIP蛋白的阳性表达率分别为75.6%(65/86)、30.0%(6/20)和43.8%(7/16),差异有统计学意义(P<0.05);Cacy BP/SIP蛋白在乳腺癌组织中的表达与组织学分级、淋巴结转移及TNM分期有统计学意义(P<0.05);Cacy BP/SIP蛋白表达与ER(r=0.275)、HER2(r=0.256)有相关性(P<0.05)。结论:Cacy BP/SIP在乳腺癌组织中高表达,且与ER、HER2的表达呈正相关,可能作为癌基因参与乳腺癌的恶性表型。     

生物反馈结合线索暴露治疗降低海洛因依赖者药物线索反应

目的:了解生物反馈结合线索暴露治疗是否降低海洛因依赖者环境线索诱发渴求及心理生理反应.方法:采用前瞻性的队列研究将60例环境线索诱发心理渴求增高的康复期海洛因依赖者分成实验组(n=36)与对照组(n=24),对照组只进行劳教场所的常规帮教,实验组除帮教外进行12次生物反馈结合线索暴露治疗,评估治疗前后环境线索诱发心理渴求与心理生理反应情况.结果:两组治疗结束后,实验组环境诱发前、后的心理渴求,肌电和皮导得分均低于对照组[诱发前:心理渴求(3.06±7.26)mm vs.(22.32±20.26)mm、肌电(8.52±4.23)μV vs.(12.06±5.17)μV、皮导(2.14±1.43)μS vs.(4.61±2.24)μS;诱发后:心理渴求(6.97±10.30)vs.(33.14±25.40)mm、肌电(8.72±4.31)vs.(14.79±5.86)μV、皮导(2.15±1.33)vs.(4.49±2.59)μS,P≤0.01].结论:生物反馈结合线索暴露治疗可降低康复期海洛因依赖者渴求及环境诱发心理生理反应.     

电缆T接线路故障测寻方法的探讨

本文对电缆T接线路的几种方式和常见的几种T接线路故障测寻方法进行了介绍。通过广州供电局110kV三景桂线T接电缆虚拟故障的测寻案例,采用几种故障测寻方法配合使用的方式,探讨了如何采取便捷方法对T接线路进行故障测寻的可能途径。同时对电缆线路的设计规划提出了作者自己的观点和建议。     

海洛因依赖者环境线索诱发心理生理反应

目的：了解海洛因依赖者对吸毒相关环境线索诱发反应。方法：对来自自愿戒毒机构的36例刚完成生理脱毒（康复早期）的海洛因依赖者和劳教戒毒机构112例康复期满1年的海洛因依赖者观看吸毒相关视频同时给予海洛因模拟物及吸毒用具刺激,于暴露前后自评渴求程度、情绪以及戒断症状反应;用生物反馈仪自动记录暴露前后的生理反应。结果：环境线索暴露后海洛因依赖者心理渴求、害怕／焦虑、抑郁／悲伤、戒断症状、心率、皮肤导电和肌电增高（P〈0．05）,中性／放松／自然降低（P〈0．05）。自愿戒毒机构康复早期海洛因依赖者环境诱发心率增高,比康复期满一年以上者更明显（P〈0．05）,其余与康复期长短无显著关系。结论：海洛因依赖者戒断康复期的延长并不会使渴求和环境诱发心理生理反应减弱或消褪。     

环境线索对戒断期海洛因依赖者神经电生理的影响

Objective To explore the changes of craving and neuro-electrophysiological reactions under the exposure of heroin-related cues in abstinent heroin dependents.Methods In this self-controlled study,382 abstinent heroin dependent patients watched video of heroin smoking and injecting situations,and in the meantime were exposed to herein simulacrum and apparatus after relaxation exercises.The neuroelectrophysiological reactions were mcagured with a multi-biofeedback instrument before and after the cue exposed.Self-reported craving was also assessed before and after cue exposed.Results The craving were increased[(18±22)mm vs.(29±29)mm,P＜0.01]after cue exposures compared to pre-exposure,EMG[(12±7)μN vs.(14±10)μV,P＜0.01]and SC[(6.8±4.3)μS vs.(7.4±4.3)μS,P＜0.01]also increased.But the percentages of δ,θ,α,SMR,low β,high β decreased compared to that under the cue exposures[8:(10.8±4.7)%vs.(9.7±4.4)%,P＜0.01;0:(6.8±2.0)%vs.(6.3±2.0)%,P＜0.01;α:(4.8±1.8)%vs.(4.5±1.7)%,P＜0.01;SMR:(3.0 ±1.2)%vs.(2.8±1.2)%,P＜0.01;low β:(2.6±1.1)%vs.(2.5±1.1)%,P＜0.01 and high β:(4.6 ±1.5)%vs.(4.5±1.5)%.P＜0.05].Conclusions The results indicate that drug-related cue induce heroin craving and electrophysiological reactions.     

环境线索对戒断期海洛因依赖者神经电生理的影响

Objective To explore the changes of craving and neuro-electrophysiological reactions under the exposure of heroin-related cues in abstinent heroin dependents.Methods In this self-controlled study,382 abstinent heroin dependent patients watched video of heroin smoking and injecting situations,and in the meantime were exposed to herein simulacrum and apparatus after relaxation exercises.The neuroelectrophysiological reactions were mcagured with a multi-biofeedback instrument before and after the cue exposed.Self-reported craving was also assessed before and after cue exposed.Results The craving were increased[(18±22)mm vs.(29±29)mm,P＜0.01]after cue exposures compared to pre-exposure,EMG[(12±7)μN vs.(14±10)μV,P＜0.01]and SC[(6.8±4.3)μS vs.(7.4±4.3)μS,P＜0.01]also increased.But the percentages of δ,θ,α,SMR,low β,high β decreased compared to that under the cue exposures[8:(10.8±4.7)%vs.(9.7±4.4)%,P＜0.01;0:(6.8±2.0)%vs.(6.3±2.0)%,P＜0.01;α:(4.8±1.8)%vs.(4.5±1.7)%,P＜0.01;SMR:(3.0 ±1.2)%vs.(2.8±1.2)%,P＜0.01;low β:(2.6±1.1)%vs.(2.5±1.1)%,P＜0.01 and high β:(4.6 ±1.5)%vs.(4.5±1.5)%.P＜0.05].Conclusions The results indicate that drug-related cue induce heroin craving and electrophysiological reactions.     

上海地区海洛因注射者的HIV高危性行为分析

目的 我国爱滋病感染者中43%是海洛因注射者（IDUs），既往研究多关其高危注射行为，本研究将对IDUs中的高危性行为情况进行分析。方法 收集了上海141名住院戒毒者的临床资料、HIV、HBV、HCV感染情况、性行为、艾滋病毒/艾滋病（HIV/AIDS）相关知识和态度及其他社会心理学因素，并分析了海洛因注射者高危性行为的影响因素。结果 IDUs中高危性行为非常普遍：77%不能坚持使用避孕套，25.5%有多个性伙伴，48.2%有IDUs性伙伴，75.9%不了解对方HIV感染情况；首次吸毒年龄小、注射过量次数多、对避孕套的否定态度、共用不洁注射工具与不安全性行为有关的因素有，而未婚、继续使用避孕套意愿、自愿HIV检测等与安全性行为有关。结论 上海地区IDUs中高危性行为普遍存在，不能忽视对IDUs中高危行为的研究。     

环境线索对戒断期海洛因依赖者神经电生理的影响

Objective To explore the changes of craving and neuro-electrophysiological reactions under the exposure of heroin-related cues in abstinent heroin dependents.Methods In this self-controlled study,382 abstinent heroin dependent patients watched video of heroin smoking and injecting situations,and in the meantime were exposed to herein simulacrum and apparatus after relaxation exercises.The neuroelectrophysiological reactions were mcagured with a multi-biofeedback instrument before and after the cue exposed.Self-reported craving was also assessed before and after cue exposed.Results The craving were increased[(18±22)mm vs.(29±29)mm,P＜0.01]after cue exposures compared to pre-exposure,EMG[(12±7)μN vs.(14±10)μV,P＜0.01]and SC[(6.8±4.3)μS vs.(7.4±4.3)μS,P＜0.01]also increased.But the percentages of δ,θ,α,SMR,low β,high β decreased compared to that under the cue exposures[8:(10.8±4.7)%vs.(9.7±4.4)%,P＜0.01;0:(6.8±2.0)%vs.(6.3±2.0)%,P＜0.01;α:(4.8±1.8)%vs.(4.5±1.7)%,P＜0.01;SMR:(3.0 ±1.2)%vs.(2.8±1.2)%,P＜0.01;low β:(2.6±1.1)%vs.(2.5±1.1)%,P＜0.01 and high β:(4.6 ±1.5)%vs.(4.5±1.5)%.P＜0.05].Conclusions The results indicate that drug-related cue induce heroin craving and electrophysiological reactions.     

宁夏某医院225例非小细胞肺癌患者EGFR基因突变检测结果分析

目的分析宁夏某医院非小细胞肺癌(NSCLC)患者表皮生长因子受体(EGFR)基因突变检测结果。方法选择2014年1月至2017年12月在宁夏医科大学总医院住院的NSCLC患者225例进行回顾性分析,用扩增阻滞突变系统-聚合酶链反应(ARMS-PCR)检测EGFR基因突变情况。结果 EGFR基因总突变率50.22%(113/225),最常见突变位点为19外显子19-del及21外显子L858R,突变率分别为21.33%及17.78%,20外显子T790M耐药突变率及20-Ins插入突变(非敏感突变)的突变率分别为3.56%及1.33%;EGFR各外显子双突变共10例;EGFR基因突变率在性别、年龄、民族、季节、标本类型之间差异无统计学意义(P>0.05),在年份、病理类型之间差异有统计学意义(P<0.05)。结论 ARMS-PCR可有效应用于临床病理石蜡标本基因突变检测,EGFR基因在19和21外显子存在较高的突变率,其突变亚型能指导小分子表皮生长因子酪氨酸酶抑制剂(EGFR-TKI)的肿瘤靶向治疗。     

氨氯地平治疗原发性高血压80例疗效观察

目的：考察氨氯地平对原发性高血压的治疗效果。方法：以沈阳医学院附属医院80例原发性高血压患者为样本，口服给药氨氯地平5mg，每天一次，连续给药8周，比较治疗前后血压变化情况。结果：治疗8周后，显效49例，有效22例，无效9例，总有效率达88．75％；与治疗前比较，收缩压和舒张压明显降低。结论：氨氯地平治疗原发性高血压疗效突出，是治疗高血压的理想药物。