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Development of recombinant stable house dust mite allergen Der p 3 molecules for component‐resolved diagnosis and specific immunotherapy 下载免费PDF全文
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Carine Salliot Amélie Denis Emmanuelle Dernis Vincent Andre Aleth Perdriger Jean-David Albert Saloua Mammou Mraghni Isabelle Griffoul-Espitalier Mohamed Hamidou Benoit Le Goff Sandrine Jousse Joulin Thierry Marhadour Christophe Richez Nicolas Poursac Estebaliz Lazaro Stéphanie Rist Anca Corondan Clara Quinten Emilie Ducourau 《Joint, bone, spine : revue du rhumatisme》2018,85(6):741-745
Objectives
The aims of this study in SLE population were (1) to describe ultrasonography (US) joint abnormalities, (2) to estimate the reliability of clinical swollen joint count (C-SJC) and SLEDAI (C-SLEDAI) versus US-SJC and US-SLEDAI scores, (3) to highlight specific patterns of lupus patients with Power Doppler (PD) abnormalities.Method
For this cross-sectional multicenter study, 151 consecutive adult SLE patients were recruited. Evaluation included a clinical standardized joint assessment, B-mode and PD US of 40 joints and 26 tendons blinded for clinical examination. Reliability and agreement between clinical and B-mode US were calculated using the intraclass correlation coefficients (ICC [95% Confidence Interval]).Results
We found a very high frequency of subclinical US abnormalities in asymptomatic patients: 85% of patients without joint symptoms had at least 1 US abnormality. Among them 46 patients (87%) had a history of joint involvement. The most frequent abnormalities were joint effusmaions (108 patients), synovial hypertrophy (SH, 109 patients) and synovitis (61 patients). Joint or tendon PD signal (grade > 1) was found in 44% of patients (67/151). Synovitis were mainly located especially on MCPs and wrists. Even if reliability between clinical and grey-scale US SJC assessments was poor, reliability between clinical and US SLEDAI was good. Comparison between SLE patients with and without PD signal did not show any specific SLE pattern.Conclusion
US may be useful to assess joint involvement in SLE patients but did not significantly change SLEDAI score. 相似文献5.
Background
Lower trapezius transfer can restore external rotation in brachial plexus palsies. In some cuff tear arthropathies, there is lack of active external rotation with a preservation of forward elevation. We evaluated the clinical outcomes of a lower trapezius transfer extended with a semitendinosus tendon and fixed to the insertion of the infraspinatus via arthroscopy.Methods
Between 2013 and 2016, we operated on 14 patients (8 men, 6 women; mean age of 62 years, range: 50–70) to reconstruct irreparable posterosuperior rotator cuff tear. A vertical incision of 6 cm following the medial border of the spine was made to harvest the lower trapezius in extension with the semitendinosus tendon. The extension band of the lower trapezius was fixed laterally via arthroscopy on the great tuberosity at the level of the insertion of the infraspinatus. The proximal stump of this extension band was then fixed medially into the muscle of the lower trapezius with the arm in maximum external rotation. Outcomes were evaluated with the Constant–Murley score, simple shoulder test (SST), and subjective shoulder value (SSV).Results
Over a mean follow-up of 24 months (range: 12–36 months), the gain in external rotation with the arm at the side was 24° and 40° in 90° of abduction. The Constant–Murley score improved from 35 to 60 points, the SST from 3.5 to 7.5, the SSV from 30 to 60%, and the pain decreased from 7 to 2 (visual analogue scale, 0–10). Both the lag sign and hornblower sign were negative after this transfer. There were two cases of hematomas, and one was revised because of infection.Conclusion
Lower trapezius transfer is a therapeutic option for irreparable posterosuperior cuff tears with a lack of active external rotation and a good subscapularis. Patients can expect improvements in pain and in active external rotation without any loss of active anterior elevation.6.
I. Ghorbel F. Bouaziz K. Loukil S. Moalla M. Gassara K. Ennouri 《Archives de pédiatrie》2019,26(3):158-160
Introduction
Burns are among the most frequent injuries in children. They are a major cause of morbidity and mortality in low- and middle-income countries. This study aimed to describe the epidemiological aspects of burns in this environment and to propose preventive measures.Patients and methods
A retrospective study was conducted between 1 January 2012 and 31 December 2013. It included children less than 16 years old who were hospitalized for burn injuries in our department. We adopted the hospitalization criteria proposed by the French Society for the Study and Treatment of Burns. The data were collected from medical records and concerned both patients and burn characteristics.Results
We recorded 67 cases, with 44.7% under 4 years old and boys (61%) more involved than girls (39%). The incidence of burns peaked in winter (31%) and summer (27%). Burns occurred at home in 95% of the cases. Hot liquids were the leading cause of children's burns. The time lapse between the accident and admission to the hospital was less than 24 h in 57% of the cases. The average total body surface area (TBSA) burned was 8.8%. Only five patients presented a TBSA ≥ 20%. The depth of the burns was superficial second-degree burns in 59% of cases. The burn involved mainly the upper limbs (65%). The average length of the hospital stay was 20.5 days. Only one patient died from severe sepsis.Conclusion
The lack of specialized burn centers in Tunisia associated with the low socioeconomic level of our population worsened the outcome of pediatric burns. The best solution lies in prevention. 相似文献7.
H. Ghadhoune A. ChaariN. Baccouche H. ChellyM. Bouaziz 《Annales fran?aises d'anesthèsie et de rèanimation》2013
Hydatid cyst of the liver (HCL) is a widespread disease in North African countries. We report the case of a 39-year-old patient who was admitted in our intensive care unit because of anaphylactic shock due to a cracked HCL fortuitously discovered. This accident was also complicated by an ischemic stroke witch underline mechanisms are discussed. 相似文献
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G. Corbonnois G. Iohom C. Lazarescu I. Hubert H. Bouaziz 《Annales fran?aises d'anesthèsie et de rèanimation》2013
Acute glaucoma angle closure is a rare complication of anaesthesia and multimodal analgesia. However it is a medical emergency, hence any delay in its treatment may have catastrophic consequences. We present a case of postoperative glaucoma, which had evolved to permanent blindness. We also reviewed the French pharmacovigilance database between 1996 and 2006 and found four other cases of acute glaucoma angle closure in postoperative period possibly related to the administration of nefopam. 相似文献