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Enamel solubility rates were determined in vivo to depths of 1 to 2 mum in the teeth from two samples of naval recruits that had been grouped, respectively, according to DMFT scores and visual indexes of oral hygiene status. No positive correlation between enamel solubility rates and DMFT scores were observed; rather there was a tendency for caries-resistant participants to have a highest apparent enamel solubility rates, even though mean differences among the DMFT groups were not generally significant. Intra-subject measurements on 12 teeth per participant for eight of the recruits showed, on the average, only about one half the variability founl incisors for more than 70 of the recruits. The least variability was found for measurements on paired maxillary central incisors. It was concluded that factors such as tooth morphology and, in particular, tooth-surface films could considerably affect enamel solubility rates measured in vivo. 相似文献
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de Herder WW Kwekkeboom DJ Feelders RA van Aken MO Lamberts SW van der Lely AJ Krenning EP 《Pituitary》2006,9(3):243-248
Tumors and metastases that express the somatostatin receptor subtypes sst2 sst3 or sst5 can be visualized in vivo after injection of radiolabeled octapeptide somatostatin analogs, like 111In-pentetreotide. 111In-pentetreotide scintigraphy also allows for more accurate staging of the disease by demonstrating tumor sites, which were
not shown by conventional imaging. 111In-pentetreotide scintigraphy may also detect resectable tumors that would have remained unrecognized using conventional radiological
imaging techniques; it may prevent surgery with curative intent in those patients whose tumors have metastasized to a greater
extend than could be detected with conventional radiological imaging and it may be used to select patients for treatment with
the currently available octapeptide somatostatin analogs or with tumor targeted radioactive treatment with radiolabelled somatostatin
analogs.
111In-pentetreotide scintigraphy has also been used to select patients with pituitary tumors for medical treatment with octapeptide
analogs, but its clinical usefulness for this purpose seems to be limited. It further allows scar tissue to be differentiated
from tumor recurrence after the pituitary surgery or radiotherapy. However, a large variety of lesions in and around the pituitary
region also express somatostatin receptors and, therefore, can be visualized by 111In-pentetreotide scintigraphy. 相似文献
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Laetitia E. Lamberts Derk Jan A. de Groot Rico D. Bense Elisabeth G.E. de Vries Rudolf S.N. Fehrmann 《Oncotarget》2015,6(29):28164-28172
The membrane bound glycoprotein mesothelin (MSLN) is a highly specific tumor marker, which is currently exploited as target for drugs. There are only limited data available on MSLN expression by human tumors. Therefore we determined overexpression of MSLN across different tumor types with Functional Genomic mRNA (FGM) profiling of a large cancer database. Results were compared with data in articles reporting immunohistochemical (IHC) MSLN tumor expression. FGM profiling is a technique that allows prediction of biologically relevant overexpression of proteins from a robust data set of mRNA microarrays. This technique was used in a database comprising 19,746 tumors to identify for 41 tumor types the percentage of samples with an overexpression of MSLN compared to a normal background. A literature search was performed to compare the FGM profiling data with studies reporting IHC MSLN tumor expression. FGM profiling showed MSLN overexpression in gastrointestinal (12–36%) and gynecological tumors (20–66%), non-small cell lung cancer (21%) and synovial sarcomas (30%). The overexpression found in thyroid cancers (5%) and renal cell cancers (10%) was not yet reported with IHC analyses. We observed that MSLN amplification rate within esophageal cancer depends on the histotype (31% for adenocarcinomas versus 3% for squamous-cell carcinomas). Subset analysis in breast cancer showed MSLN amplification rates of 28% in triple-negative breast cancer (TNBC) and 33% in basal-like breast cancer. Further subtype analysis of TNBCs showed the highest amplification rate (42%) in the basal-like 1 subtype and the lowest amplification rate (9%) in the luminal androgen receptor subtype. 相似文献
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van Zantvoort Aniek Setz Maikel Hoogeveen Adwin van Eerten Percy Scheltinga Marc 《Der Unfallchirurg》2019,122(11):854-859
Die Unfallchirurgie - Junge Menschen mit chronischen belastungsabhängigen Unterschenkelschmerzen, bei denen normale Druckverhältnisse im Muskelkompartiment herrschen und ein... 相似文献
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SummaryIrradiation causes atheromatotic changes in the coronary arteries, leading to occlusion of these vessels. In two out of ten animals, E.C.G. changes were found, which were characteristic for a myocardial infarct. This was confirmed at necropsy. One example is given of a young patient in whom radiotherapy was the cause of fatal pulmonary and myocardial fibrosis. 相似文献
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Robert J. Lamberts Sergio Laranjo Stiliyan N. Kalitzin Demetrios N. Velis Isabel Rocha Josemir W. Sander Roland D. Thijs 《Epilepsia》2013,54(3):523-529
Purpose: Postictal generalized EEG suppression (PGES) seems to be a pathophysiologic hallmark in ictal recordings of sudden unexpected death in epilepsy (SUDEP). It has recently been suggested that presence and duration of PGES might be a predictor of SUDEP risk. Little is known about the etiology of PGES. Methods: We conducted a retrospective case–control study in 50 people with convulsive seizures (CS) recorded on digital video–electroencephalography (EEG). One CS per individual was reviewed for presence and duration of PGES by two independent observers: Preictal and postictal heart rate (HR) (1 min before seizure onset and 1, 3, 5, 15, and 30 min after seizure end) and frequency domain measures of heart rate variability (HRV), including the ratio of low frequency (LF) versus high frequency (HF) power, were analyzed. The relationship between PGES and periictal autonomic changes was evaluated, as well as its association with several clinical variables. Key Findings: Thirty‐seven individuals (74%) exhibited PGES and 13 (26%) did not. CS resulted in a significant increase of periictal HR and the LF/HF ratio. PGES was associated with neither periictal HR (mean HR difference between PGES+ and PGES? seizures: ?2 beats per minute [bpm], 95% confidence interval [CI] ?10 to +6 bpm) nor HRV change. There was no association between the duration of PGES and periictal HR change. People with PGES were more likely to be asleep before seizure onset (odds ratio [OR] 4.7, 95% CI 1.2–18.3) and had a higher age of onset of epilepsy (median age 15 vs. 4 years). Significance: PGES was not associated with substantial changes in measures of cardiac autonomic instability but was more prevalent in CS arising from sleep. 相似文献