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目的对比分析组织多肽特异性抗原(TPS)与多个糖类抗原(CA)血清浓度,探讨TPS对胰腺癌的诊断价值。方法血清标本来自慢性胰腺炎患者33例,非胰腺恶性肿瘤患者35例,胰腺癌患者34例。TPS测量采用酶联免疫吸附测定(ELISA);CA19-9和CA125测定采用化学发光免疫分析;CA50和CA242测定采用免疫放射分析法。测量数据采用SPSS9.0统计软件进行统计分析。结果胰腺癌患者血清TPS[(386.5±315.1)U/L]和CA19-9[(10820.9±389.7)kU/L]均明显高于慢性胰腺炎患者[分别为(86.2±28.1)U/L,(61.5±24.7)kU/L;F=936.42和2217.09,P均〈0.001]。其中,TPS灵敏度为70.6%(48/68),特异性57.4%(39/68);CA19-9灵敏度为82.4%(28/34),特异性77.9%(53/68)。联合使用TPS与CA19-9、CA50、CA125和CA242,可显著增加灵敏度(94.1%,32/34),减少漏诊率。结论TPS作为CA19-9的有益补充,可提高诊断胰腺癌的灵敏度。 相似文献
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Objective To compare the diagnostic value of tissue polypeptide specific antigen (TPS) in serum, with the carbohydrate antigens (CA) 19-9, CA50, CA125 and CA242 in pancreatic carci-noma. Methods Serum TPS was measured with enzyme linked immunosorbent assay (ELISA). CA19-9 and CA125 were measured with chemiluminescent immunoassay. CAS0 and CA242 were measured with im-munoradiometric assay in 33 patients with pancreatitis, 34 patients with pathologically proven pancreatic car-cinoma, and 35 patients with non-pancreatic malignancies. Statistic analysis was carried out with SPSS 9.0 software. Results Patients with pancreatic carcinoma had relatively higher levels of TPS [(386.5± 315. 1) U/L] and CA19-9 [(10 820.9 ± 389.7) kU/L] when compared with patients with pancreatitis [(86. 2 ± 28.1) U/L and (61.5 ± 24.7) kU/L, respectively; F = 936. 42, P < 0. 001 ; F = 2217. 09, P < 0. 001], with a sensitivity and a specificity of 70.6% (48/68) and 57.4% (39/68), respectively, for TPS, and 82.4% (28/34) and 77.9% (53/68), respectively, for CA19-9. Diagnostic performance was further improved when TPS was assayed in combination with CA19-9, CA50, CA12.5 and CA242. Conclusion Serum TPS has an incremental value in complementing CA19-9 in the diagnosis of pancreatic carcinoma. 相似文献
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鼠坐骨神经再生早期轴浆流改变的实验研究 总被引:6,自引:1,他引:5
目的探索同位素示踪早期检测神经再生的可行性,并与神经电图-肌电图检测结果进行比较,为临床应用奠定基础。方法将鼠坐骨神经切断并作神经缝合,术后1、2、3、4周用微量注射器将125I-酪氨酸直接注射入大鼠坐骨神经干内,于注射后8、12、16小时取样以γ-计数器检测其放射性。测定再生神经125I-酪氨酸转运规律,并与神经电图-肌电图检测结果、光镜下再生髓鞘形态学变化相比较。结果术后2周轴浆流即可通过缝合口,早于神经电图-肌电图出现时间;与再生髓鞘出现时间相符。结论应用轴浆流同位素示踪法早期检测神经再生,较神经电图-肌电图具有明显的优越性。 相似文献
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目的:探讨非小细胞肺癌患者治疗前血清肿瘤标志物水平与肿瘤骨转移之间的相关性。材料和方法:受检患者58名治疗前均行血清Cy21-1、SCC、NSE、CEA和CA15-3测定和SPECT全身骨显像。结果:血清Cy21-1和CA15-3水平与全身骨显像结果相关。(P<0.05),血清SCC,NSE及CEA水平则无相关(P>0.05)。结论:血清中Cy21-1和CA15-3升高水平与肿瘤骨转移之间存在正相关关系,尤以Cy21-1为著。 相似文献
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Objective To compare the diagnostic value of tissue polypeptide specific antigen (TPS) in serum, with the carbohydrate antigens (CA) 19-9, CA50, CA125 and CA242 in pancreatic carci-noma. Methods Serum TPS was measured with enzyme linked immunosorbent assay (ELISA). CA19-9 and CA125 were measured with chemiluminescent immunoassay. CAS0 and CA242 were measured with im-munoradiometric assay in 33 patients with pancreatitis, 34 patients with pathologically proven pancreatic car-cinoma, and 35 patients with non-pancreatic malignancies. Statistic analysis was carried out with SPSS 9.0 software. Results Patients with pancreatic carcinoma had relatively higher levels of TPS [(386.5± 315. 1) U/L] and CA19-9 [(10 820.9 ± 389.7) kU/L] when compared with patients with pancreatitis [(86. 2 ± 28.1) U/L and (61.5 ± 24.7) kU/L, respectively; F = 936. 42, P < 0. 001 ; F = 2217. 09, P < 0. 001], with a sensitivity and a specificity of 70.6% (48/68) and 57.4% (39/68), respectively, for TPS, and 82.4% (28/34) and 77.9% (53/68), respectively, for CA19-9. Diagnostic performance was further improved when TPS was assayed in combination with CA19-9, CA50, CA12.5 and CA242. Conclusion Serum TPS has an incremental value in complementing CA19-9 in the diagnosis of pancreatic carcinoma. 相似文献
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