芦山地震5年后雅安市高血压患者心理卫生问题检出率及其影响因素

目的 了解芦山地震5年后雅安市高血压患者心理卫生问题检出率及其影响因素，为促进地震灾区高血压患者心理健康提供参考。方法 采用分层整群随机抽样方法，于2018年12月选取雅安市高血压患者800例作为研究对象。采用自编居民基本信息调查表收集患者的基本资料，采用12项一般健康问卷（GHQ-12）评定患者近期是否存在心理卫生问题，采用Logistic回归分析其影响因素。结果 回收有效问卷744份（93.00%），检出存在心理卫生问题者79例（10.62%）。单因素分析结果显示，不同婚姻状况（P?0.01）、家庭人均月收入（P=0.012）、是否接受社会救助（χ²=25.194，P?0.01）的高血压患者心理卫生问题检出率差异均有统计学意义。Logistic回归分析显示，未婚/分居/离异/丧偶（OR=3.879，P=0.015）以及接受社会救助（OR=4.705，P?0.01）是高血压患者存在心理卫生问题的危险因素。结论 雅安市高血压患者心理卫生问题检出率较低，未婚/分居/离异/丧偶者以及接受社会救助的高血压患者心理卫生问题可能更突出。     

Venetoclax alone or in combination with other regimens treatment achieve deep and sustained remission of relapsed/refractory chronic lymphocytic leukemia: a meta-analysis

Clinical and Experimental Medicine - Recently, the use of novel targeted drugs significantly improved the overall response rate (ORR) and survival of patients with relapsed/refractory chronic...     

Calculation of the Biological Efficiency of the Proton Component from 14.8 MeV Neutron Irradiation in Computational Biology with Help of Video Cards

Bulletin of Experimental Biology and Medicine - Fast neutron therapy, which previously has demonstrated effective results, but along with a large number of complications, can again be considered a...     

Psychopharmacological Effects of Stimulation of the Functions of Neural Stem Cells by STAT3 Inhibitor under Conditions of Modeled Ethanol-Induced Encephalopathy

Bulletin of Experimental Biology and Medicine - The psychopharmacological effects of a stimulator of functions of progenitor cells of the nervous tissue STAT3 inhibitor (STAT3 Inhibitor XIV, LLL12)...     

A Mathematical Model of a Thermoelectric Device for the Treatment of Whitlow by Local Hypothermia

Biomedical Engineering - A mathematical model of a thermoelectric device for the treatment of whitlow by local hypothermia is discussed. The model is based on a solution of the heat conduction task...     

Rapalogs induce non-apoptotic,autophagy-dependent cell death in HPV-negative TP53 mutant head and neck squamous cell carcinoma

TP53 is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSCC). Patients with HPV-negative TP53 mutant HNSCC have the worst prognosis, necessitating additional agents for treatment. Since mutant p53 causes sustained activation of the PI3K/AKT/mTOR signaling pathway, we investigated the effect of rapalogs RAD001 and CCI-779 on HPV-negative mutTP53 HNSCC cell lines and xenografts. Rapalogs significantly reduced cell viability and colony formation. Interestingly, rapalogs-induced autophagy with no effect on apoptosis. Pretreatment with autophagy inhibitors, 3-methyladenine (3-MA) and ULK-101 rescued the cell viability by inhibiting rapalog-induced autophagy, suggesting that both RAD001 and CCI-779 induce non-apoptotic autophagy-dependent cell death (ADCD). Moreover, rapalogs upregulated the levels of ULK1 and pULK1 S555 with concomitant downregulation of the mTORC1 pathway. However, pretreatment of cells with rapalogs prevented the ULK-101-mediated inhibition of ULK1 to sustained autophagy, suggesting that rapalogs induce ADCD through the activation of ULK1. To further translate our in vitro studies, we investigated the effect of RAD001 in HPV-negative mutTP53 (HN31 and FaDu) tumor cell xenograft model in nude mice. Mice treated with RAD001 exhibited a significant tumor volume reduction without induction of apoptosis, and with a concomitant increase in autophagy. Further, treatment with RAD001 was associated with a considerable increase in pULK1 S555 and ULK1 levels through the inhibition of mTORC1. 3-MA reversed the effect of RAD001 on FaDu tumor growth suggesting that RAD001 promotes ACDC in HPV-negative mutTP53 xenograft. This is the first report demonstrating that rapalogs promote non-apoptotic ADCD in HPV-negative mutTP53 HNSCC via the ULK1 pathway. Further studies are required to establish the promising role of rapalogs in preventing the regrowth of HPV-negative mutTP53 HNSCC.     

Correction to: The protean world of non-coding RNAs in glioblastoma

Journal of Molecular Medicine -