全文获取类型
收费全文 | 2234篇 |
免费 | 92篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 24篇 |
妇产科学 | 37篇 |
基础医学 | 298篇 |
口腔科学 | 70篇 |
临床医学 | 183篇 |
内科学 | 632篇 |
皮肤病学 | 18篇 |
神经病学 | 178篇 |
特种医学 | 40篇 |
外科学 | 326篇 |
综合类 | 6篇 |
预防医学 | 33篇 |
眼科学 | 93篇 |
药学 | 159篇 |
中国医学 | 10篇 |
肿瘤学 | 212篇 |
出版年
2023年 | 26篇 |
2022年 | 11篇 |
2021年 | 46篇 |
2020年 | 30篇 |
2019年 | 50篇 |
2018年 | 63篇 |
2017年 | 32篇 |
2016年 | 32篇 |
2015年 | 56篇 |
2014年 | 53篇 |
2013年 | 84篇 |
2012年 | 140篇 |
2011年 | 119篇 |
2010年 | 73篇 |
2009年 | 66篇 |
2008年 | 98篇 |
2007年 | 129篇 |
2006年 | 101篇 |
2005年 | 138篇 |
2004年 | 130篇 |
2003年 | 115篇 |
2002年 | 145篇 |
2001年 | 49篇 |
2000年 | 65篇 |
1999年 | 59篇 |
1998年 | 32篇 |
1997年 | 27篇 |
1996年 | 14篇 |
1995年 | 24篇 |
1994年 | 14篇 |
1993年 | 15篇 |
1992年 | 18篇 |
1991年 | 17篇 |
1990年 | 30篇 |
1989年 | 21篇 |
1988年 | 16篇 |
1987年 | 28篇 |
1986年 | 21篇 |
1985年 | 16篇 |
1984年 | 15篇 |
1983年 | 9篇 |
1979年 | 12篇 |
1978年 | 7篇 |
1976年 | 7篇 |
1975年 | 11篇 |
1974年 | 7篇 |
1970年 | 10篇 |
1969年 | 7篇 |
1967年 | 6篇 |
1966年 | 6篇 |
排序方式: 共有2333条查询结果,搜索用时 15 毫秒
1.
2.
Cementoblast response to low- and high-intensity ultrasound 总被引:1,自引:0,他引:1
Dalla-Bona DA Tanaka E Inubushi T Oka H Ohta A Okada H Miyauchi M Takata T Tanne K 《Archives of oral biology》2008,53(4):318-323
3.
Kazuhiro Nagata Satol Hori Ryo Mizuhashi Tomoko Yokoe Yojiro Atsumi Wataru Nagai Motoatu Goto 《Journal of prosthodontic research》2019,63(2):202-209
Purpose
Manual therapy has been used for the treatment of patients with temporomandibular disorders (TMD) with mouth-opening limitations. However, the curative effect of manipulation differs among researchers, and its necessity remains controversial. The purpose of this study was to confirm the efficacy of manipulation using a randomized controlled trial (RCT).Methods
A total of 61 TMD patients who had mouth-opening limitation (upper and lower middle incisor distance ≤35 mm) were selected. They were divided into two treatment groups: conventional treatment (n = 30) and conventional treatment plus manipulation (n = 31). The conventional treatment included two types of self-exercise: cognitive behavioral therapy for bruxism and education. Mouth-opening limitation, orofacial pain, and temporomandibular joint (TMJ) sounds were recorded from baseline to 18 weeks after baseline. These parameters were statistically compared between the two treatment groups by using analysis of variance (ANOVA) and Scheffe’s test to assess mouth opening distance and pain; TMJ sounds were compared using Mann–Whitney U test.Results
No statistical difference was observed between the two treatment groups except for mouth-opening limitation after treatment at the first visit. Subgroup analyses, stratified according to the pathological type of TMD, indicated a similar trend.Conclusions
The efficacy of manipulation seems to be limited, in contrast to our expectations, and improved execution of therapeutic exercises has a similar effect to that of manipulation during long-term observation. The advantage of manipulation was observed only during the first treatment session. The RCT was registered in the University Hospital Medical Information Network in Japan (UMIN-CTR: 000010437). 相似文献4.
M Morishita R Shiba H Chiyo J Furuyama H Fujita Y Atsumi 《Journal of oral and maxillofacial surgery》1983,41(9):601-605
The oral manifestations of 80 reported cases of 4p- syndrome are analyzed and a new case is reported. Results indicate that the common pattern of cheilognathopharyngeal disorders in 4p- syndrome is an isolated cleft palate or a high-arched palate with micrognathia. Cases of cleft lip are only about 10% of the total. The significance of other reported aberrant phenomena cannot yet be estimated. 相似文献
5.
Kengo Nomura Sawako Tatsumi Atsumi Miyagawa Yuji Shiozaki Shohei Sasaki Ichiro Kaneko Mikiko Ito Shinsuke Kido Hiroko Segawa Mitsue Sano Tsutomu Fukuwatari Katsumi Shibata Ken-ichi Miyamoto 《Journal of the American Society of Nephrology : JASN》2014,25(4):761-772
Marked hypophosphatemia is common after major hepatic resection, but the pathophysiologic mechanism remains unknown. We used a partial hepatectomy (PH) rat model to investigate the molecular basis of hypophosphatemia. PH rats exhibited hypophosphatemia and hyperphosphaturia. In renal and intestinal brush-border membrane vesicles isolated from PH rats, Na+-dependent phosphate (Pi) uptake decreased by 50%–60%. PH rats also exhibited significantly decreased levels of renal and intestinal Na+-dependent Pi transporter proteins (NaPi-IIa [NaPi-4], NaPi-IIb, and NaPi-IIc). Parathyroid hormone was elevated at 6 hours after PH. Hyperphosphaturia persisted, however, even after thyroparathyroidectomy in PH rats. Moreover, DNA microarray data revealed elevated levels of nicotinamide phosphoribosyltransferase (Nampt) mRNA in the kidney after PH, and Nampt protein levels and total NAD concentration increased significantly in the proximal tubules. PH rats also exhibited markedly increased levels of the Nampt substrate, urinary nicotinamide (NAM), and NAM catabolites. In vitro analyses using opossum kidney cells revealed that NAM alone did not affect endogenous NaPi-4 levels. However, in cells overexpressing Nampt, the addition of NAM led to a marked decrease in cell surface expression of NaPi-4 that was blocked by treatment with FK866, a specific Nampt inhibitor. Furthermore, FK866-treated mice showed elevated renal Pi reabsorption and hypophosphaturia. These findings indicate that hepatectomy-induced hypophosphatemia is due to abnormal NAM metabolism, including Nampt activation in renal proximal tubular cells.Inorganic phosphate (Pi) absorption in the renal proximal tubules and small intestine is important for Pi homeostasis.1 The Na+-dependent Pi (Na/Pi) transport system includes type IIa and type IIc Na/Pi transporters, which are localized in the apical membrane of the proximal tubular cells, and type IIb Na/Pi transporters, which are localized in the apical membrane of the intestinal epithelial cells.1,2 Pi (re)absorption is regulated by the dietary Pi content, parathyroid hormone (PTH), and the active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D3 [1,25(OH)2D3].3 Other phosphaturic hormones, termed phosphatonins, also control renal Pi handling.4 The discovery that fibroblast growth factor (FGF) 23, the first identified phosphatonin,5 originated from osteocytes established the concept of the bone-kidney axis.6,7The incidence of liver transplantation has steadily increased and the incidence of partial hepatectomy (PH) has also consequently increased.8 Hypophosphatemia frequently occurs after liver resection.9–11 Acute hypophosphatemia causes septicemia and is associated with a poor prognosis.11,12 Acute hypophosphatemia is of considerable clinical relevance because many hepatectomized patients develop marked hypophosphatemia and, thus, large doses of Pi replacement are required to maintain metabolic homeostasis.13 Urinary Pi excretion is markedly increased in many patients. After hepatectomy, hypophosphatemia is associated with hyperphosphaturia.13For many years, the increased metabolic demand of the regenerating liver was considered the underlying pathologic mechanism of hypophosphatemia. The magnitude of Pi uptake by the recovering liver, however, cannot explain the severity of the resulting hypophosphatemia.11 Hepatectomy-induced hypophosphatemia is associated with an increased renal fractional excretion index for Pi unrelated to intact FGF23, FGF7, or secreted frizzled-related protein 4 as a phosphaturic factor,14 indicating that other factors have a role in the pathogenesis of hypophosphatemia.Nicotinamide (NAM) inhibits intestinal and renal Na/Pi transport activity in normal rats.15–17 Administration of NAM to rats produces a specific dose-dependent inhibition of Na/Pi transport across the renal brush-border membrane (BBM) and an increase in urinary Pi excretion.16,17 NAM suppresses hyperphosphatemia in hemodialysis patients.18 Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the first rate-limiting step in converting NAM to NAD,19,20 which is essential for cellular metabolism, energy production, and DNA repair.20–22 Nampt exists in two known forms: intracellular Nampt (iNampt) and secreted extracellular Nampt (eNampt).23 eNampt also generates an intermediate product, nicotinamide mononucleotide (NMN).23Our findings indicate that the acceleration of NAM metabolism through Nampt function in the kidney is involved in the hepatectomy-induced hypophosphatemia in rodent models. This study also suggests that NAM metabolism through the liver-kidney axis is important in Pi homeostasis. 相似文献
6.
7.
8.
9.
Differences in semen characteristics between patients with testicular cancer and other malignancies using various cut‐off values 下载免费PDF全文
10.