全文获取类型
收费全文 | 10611篇 |
免费 | 1417篇 |
国内免费 | 55篇 |
专业分类
耳鼻咽喉 | 182篇 |
儿科学 | 384篇 |
妇产科学 | 229篇 |
基础医学 | 1290篇 |
口腔科学 | 854篇 |
临床医学 | 953篇 |
内科学 | 2438篇 |
皮肤病学 | 389篇 |
神经病学 | 668篇 |
特种医学 | 340篇 |
外科学 | 1781篇 |
综合类 | 239篇 |
一般理论 | 4篇 |
预防医学 | 573篇 |
眼科学 | 258篇 |
药学 | 669篇 |
中国医学 | 49篇 |
肿瘤学 | 783篇 |
出版年
2023年 | 96篇 |
2022年 | 100篇 |
2021年 | 421篇 |
2020年 | 396篇 |
2019年 | 595篇 |
2018年 | 675篇 |
2017年 | 518篇 |
2016年 | 553篇 |
2015年 | 504篇 |
2014年 | 646篇 |
2013年 | 803篇 |
2012年 | 785篇 |
2011年 | 876篇 |
2010年 | 577篇 |
2009年 | 414篇 |
2008年 | 514篇 |
2007年 | 487篇 |
2006年 | 433篇 |
2005年 | 458篇 |
2004年 | 419篇 |
2003年 | 332篇 |
2002年 | 282篇 |
2001年 | 168篇 |
2000年 | 146篇 |
1999年 | 119篇 |
1998年 | 58篇 |
1997年 | 44篇 |
1996年 | 45篇 |
1995年 | 40篇 |
1994年 | 32篇 |
1993年 | 31篇 |
1992年 | 37篇 |
1991年 | 23篇 |
1990年 | 28篇 |
1989年 | 31篇 |
1988年 | 43篇 |
1987年 | 50篇 |
1986年 | 42篇 |
1985年 | 37篇 |
1984年 | 34篇 |
1983年 | 18篇 |
1982年 | 12篇 |
1981年 | 17篇 |
1979年 | 16篇 |
1978年 | 8篇 |
1977年 | 14篇 |
1976年 | 9篇 |
1975年 | 10篇 |
1966年 | 8篇 |
1965年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Raya Saab MD Anas Obeid MD Fatiha Gachi MD Houda Boudiaf MD Lilit Sargsyan MD Khulood Al-Saad MD Tamar Javakhadze MD Azim Mehrvar MD Sawsan Sati Abbas MD Yasir Saadoon Abed Al-Agele MD Salma Al-Haddad MD Mouroge Hashim Al Ani MD Suleiman Al-Sweedan MD Amani Al Kofide MD Wasil Jastaniah MD Nisreen Khalifa MD Elie Bechara MD Malek Baassiri MD Peter Noun MD Jamila El-Houdzi MD Mohammed Khattab MD Krishna Sagar Sharma MD Yasser Wali MD Naureen Mushtaq MD Aliya Batool MD Mahwish Faizan MD Muhammad Rafie Raza MD Mohammad Najajreh MD Mohammed Awad Mohammed Abdallah MD Ghada Sousan MD Khaled M. Ghanem MD Ulker Kocak MD Tezer Kutluk MD Hacı Ahmet Demir MD Hamoud Hodeish MD Samar Muwakkit MD Asim Belgaumi MD Abdul-Hakim Al-Rawas MD Sima Jeha MD 《Cancer》2020,126(18):4235-4245
2.
Expression of Salivary S100A7 Levels in Stage I Oral Submucous Fibrosis: A Clinical and Laboratory Study 下载免费PDF全文
Muhammad Arsalan RaffatNaila Irum HadiOsama AlghamdiKhulud Abdulrahman Al-AaliModhi Al DeebTariq AbduljabbarFahim Vohra 《Asian Pacific journal of cancer prevention》2020,21(4):1115-1119
Background: Oral submucous fibrosis (OSF) is a chronic debilitating condition characterized by juxta-epithelial fibrosis. The main etiological agent associated with the high-risk precancerous condition is areca nut use. S100A7 is a member of the largest calcium-binding proteins exclusively found in vertebrates and are associated with the regulation of numerous intracellular and extracellular functions. The aim of this study was to investigate the expression of protein S100A7 in salivary samples of individuals with stage I OSF and healthy controls. Methods: This study included 63 participants, 30 of whom had OSF stage I and 33 healthy controls. Nonprobability quota sampling technique was utilized for recruitment of the study participants. A structured baseline questionnaire was used to collect demographic data. Saliva samples were collected by passive droll technique in a sterile container. Salivary levels of S100A7 were quantified by enzyme-linked immunosorbent assay. For the normality of the data Shapiro Wilk test was performed. Student t-test was commuted to evaluate the expression of S100A7 protein expression between both the study groups. Results: The mean salivary S100A7 value for stage I OSF group was 0.334 ng/ml, compared to 0.172 ng/ml for healthy controls. Student t-test reported a statistically significant difference, indicating higher levels of S100A7 in stage I OSF group than in healthy controls (p < 0.001). In the individual group analysis, a significant negative correlation was found between salivary S100A7 and duration of areca nut use (r = –0.45, p = 0.009) and gutka chewing (r = –0.20, p = 0.03), while a significant positive correlation was found between salivary S100A7 and mouth opening (r = 0.03, p = 0.04). Conclusions: Higher levels of S100A7 protein level was seen in stage I OSF group in comparison to the healthy individuals. Results of our study suggest that S100A7 could be used as a surrogate assessment to identify patients at risk of OSF development. 相似文献
3.
4.
Non‐melanoma skin cancer frequently results from chronic exposure to ultraviolet (UV) irradiation. UV‐induced DNA damage activates cell cycle arrest checkpoints through degradation of the cyclin‐dependent kinase activators, the cell division cycle 25 (CDC25) phosphatases. We previously reported increased CDC25A in nonmelanoma skin cancer, but CDC25B and CDC25C had not been previously examined. Consequently, we hypothesized that increased expression of CDC25B and CDC25C increases tumor cell proliferation and skin tumor growth. We found that CDC25B and CDC25C were increased in mouse and human skin cancers. CDC25B was primarily cytoplasmic in skin and skin tumors and was significantly increased in the squamous cell carcinoma (SCC), while CDC25C was mostly nuclear in the skin, with an increased cytoplasmic signal in the premalignant and malignant tumors. Surprisingly, forced expression of CDC25B or CDC25C in cultured SCC cells did not affect proliferation, but instead suppressed apoptosis, while CDC25C silencing increased apoptosis without impacting proliferation. Targeting CDC25C to the nucleus via mutation of its nuclear export sequence, however, increased proliferation in SCC cells. Overexpression of CDC25C in the nuclear compartment did not hinder the ability of CDC25C to suppress apoptosis, neither did mutation of sites necessary for its interaction with 14‐3‐3 proteins. Analysis of apoptotic signaling pathways revealed that CDC25C increased activating phosphorylation of Akt on Ser473, increased inhibitory phosphorylation of proapoptotic BAD on Ser136, and increased the survival protein Survivin. Silencing of CDC25C significantly reduced Survivin levels. Taken together, these data suggest that increased expression of CDC25B or CDC25C are mechanisms by which skin cancers evade apoptotic cell death. 相似文献
5.
6.
El Darawany Hamed M. Al Damhogy Mahmoud E. Kandil Mohamed S. ELkordi Mohamed E. Nagla Salah A. Taha Mohamed R. 《International urology and nephrology》2019,51(8):1313-1319
International Urology and Nephrology - To report our experience in starting the correction of penile torsion, whatever its degree (moderate or severe) with one or more simple procedures either... 相似文献
7.
8.
Fahad A. Bashiri Hissah K. Al Abdulsalam Saeed M. Hassan Waleed A. Al Twaijri Fuad I. Almalki Amal Y. Kentab Muddathir H. Hamad Ali H. Alwadei Daniah A. Al-Showaeir Ikhlass S. Altweijri Haifa M. Aldabjan Moudi S. Aldegether Abdulrahman A. Albakr Wajda M. Alhothali Abdulrazag M. Ajlan Hamdy H. Hassan Mustafa A. Salih 《Neurosciences (Riyadh, Saudi Arabia)》2019,24(4):257
Objectives:To review the experience of 2 tertiary centers in Saudi Arabia with intracranial hypertension (IH) in the pediatric population.Methods:We retrospectively reviewed and analyzed pediatric patients diagnosed with IH from June 2002 to May 2017 in 2 institutes.Results:We identified 53 patients (30 females and 23 males) with a mean age of 7 years at the time of presentation. Among them, 41 patients were younger than 12 years, and 12 were older. Obese and overweight patients constituted 27.00% (n = 14) of all cases, 8 (66.7%) of whom were older than 12 years. The most common presenting feature was papilledema followed by headache. Vitamin D deficiency, which constituted the most common associated condition, was identified in 12 (22.6%) patients. Acetazolamide was the treatment option in 98.11% of patients, and only 5.7% underwent surgical interventions. The length of follow-up ranged from 6 months to 8 years.Conclusion:Intracranial hypertension is rare in children and commonly seen in overweight females older than 12 years similar to adults. Patients younger than 12 years tend to develop secondary IH. More studies are needed to characterize the clinical presentation and guide the management plan.Intracranial hypertension (IH) is rarely reported in children. It is characterized by increased intracranial pressure (ICP) without any evidence of underlying brain pathology, structural abnormalities, hydrocephalus, or any abnormal meningeal enhancement.1 The incidence of IH differs from region to region due to variations in the prevalence of obesity and other secondary causes. The annual incidence of IH in children is 0.9 per 100,000 in the United States,2 0.5 per 100,000 in Germany,3 0.6 per 100,000 in Nova Scotia and Prince Edward Island in Eastern Canada,4 and 1.2 per 100,000 in Croatia.5 A study carried out in Oman estimated the incidence of IH to be 1.9 per 100,000 in children below 15 years of age; with it being higher in female children.6 The present study aimed to review the clinical presentation, possible aetiological factors, diagnosis, management, and outcomes in children with IH in 2 tertiary institutes in Saudi Arabia. 相似文献
9.
10.
Lauren E. Wiznia Suneet Bhansali Nooshin Brinster Yasir M. Al‐Qaqaa Seth J. Orlow Vikash Oza 《Pediatric dermatology》2019,36(4):520-523
Well‐known causes of zinc deficiency, also referred to as acrodermatitis enteropathica (AE), include defects in intestinal zinc transporters and inadequate intake, but a rare cause of acquired zinc deficiency discussed here is an iatrogenic nutritional deficiency caused by parenteral nutrition administered without trace elements. While zinc‐depleted parenteral nutrition causing dermatosis of acquired zinc deficiency was first reported in the 1990s, it is now again relevant due to a national vitamin and trace element shortage. A high index of suspicion may be necessary to diagnose zinc deficiency, particularly because early clinical findings are nonspecific. We present this case of acquired zinc deficiency in a patient admitted to a pediatric intensive care unit for respiratory distress and atypical pneumonia, who subsequently developed a severe bullous eruption due to iatrogenic zinc deficiency but was treated effectively with enteral and parenteral zinc supplementation, allowing for rapid re‐epithelialization of previously denuded skin. 相似文献