全文获取类型
收费全文 | 1598675篇 |
免费 | 132306篇 |
国内免费 | 2544篇 |
专业分类
耳鼻咽喉 | 21676篇 |
儿科学 | 52956篇 |
妇产科学 | 46268篇 |
基础医学 | 226912篇 |
口腔科学 | 47399篇 |
临床医学 | 139972篇 |
内科学 | 313555篇 |
皮肤病学 | 34231篇 |
神经病学 | 129555篇 |
特种医学 | 64978篇 |
外国民族医学 | 474篇 |
外科学 | 244911篇 |
综合类 | 39656篇 |
一般理论 | 544篇 |
预防医学 | 121964篇 |
眼科学 | 36387篇 |
药学 | 121474篇 |
2篇 | |
中国医学 | 2906篇 |
肿瘤学 | 87705篇 |
出版年
2018年 | 14667篇 |
2016年 | 12864篇 |
2015年 | 14996篇 |
2014年 | 20719篇 |
2013年 | 31500篇 |
2012年 | 42851篇 |
2011年 | 45091篇 |
2010年 | 26529篇 |
2009年 | 25435篇 |
2008年 | 43309篇 |
2007年 | 45639篇 |
2006年 | 46480篇 |
2005年 | 45085篇 |
2004年 | 44509篇 |
2003年 | 42528篇 |
2002年 | 41660篇 |
2001年 | 75928篇 |
2000年 | 78514篇 |
1999年 | 66304篇 |
1998年 | 16808篇 |
1997年 | 15426篇 |
1996年 | 15372篇 |
1995年 | 16015篇 |
1994年 | 15052篇 |
1993年 | 14213篇 |
1992年 | 55671篇 |
1991年 | 54049篇 |
1990年 | 52774篇 |
1989年 | 51070篇 |
1988年 | 47397篇 |
1987年 | 46744篇 |
1986年 | 44469篇 |
1985年 | 43076篇 |
1984年 | 32111篇 |
1983年 | 27629篇 |
1982年 | 16147篇 |
1981年 | 14423篇 |
1980年 | 13523篇 |
1979年 | 30503篇 |
1978年 | 21086篇 |
1977年 | 17745篇 |
1976年 | 16658篇 |
1975年 | 17534篇 |
1974年 | 21468篇 |
1973年 | 20669篇 |
1972年 | 18865篇 |
1971年 | 17785篇 |
1970年 | 16308篇 |
1969年 | 15308篇 |
1968年 | 14011篇 |
排序方式: 共有10000条查询结果,搜索用时 17 毫秒
1.
Shintaro Ito Nobukazu Fuwa Miwako Nomura Suguru Ota Takayuki Morishima Takashi Daimon Yoshikazu Maeda Jun Ueda Iwai Tohnai Noriko Ii Tosiaki Miyati 《Auris, nasus, larynx》2021,48(3):496-501
ObjectiveIn cases of head and neck cancer treated with intra-arterial chemotherapy, no objective indices are available for determining the distribution of anticancer drugs administered to multiple arteries. To establish such indices, noninvasive measurements of drug concentrations are required in the arterial perfusion area of each artery. In MRI, changes in 1/T1 (Δ1/T1) are correlated with the contrast agent concentration. We focused on these properties and investigated whether it is possible to estimate anticancer drug concentrations within tissue based on Δ1/T1.MethodsWe employed the fast spin echo (FSE) sequence to determine optimum imaging parameters using a phantom. Subsequently, contrast agent was administered via the lingual and external carotid arteries for seven cases of tongue cancer. Δ1/T1 were then measured in tumor and nontumor tissues. The results of this study were compared with those of a previous study in which intratumor concentrations of anticancer agent were measured in excised specimens.ResultsThe optimum imaging parameters for the FSE was two repetition times (TR, 500 and 1000 ms). When compared with the external carotid artery administration, the lingual artery administration of contrast agent resulted in significantly higher Δ1/T1 in both tumor and nontumor tissues (2.13 and 2.62 times, respectively). The multiplying factor for the nontumor tissue and high homogeneity of the contrast agent concentration were reasonably consistent with the results of the previous study.ConclusionThis method can be applied to estimating intratissue concentrations of intra-arterially administered anticancer drugs, thus possibly providing useful information in determining the distribution of anticancer drugs. 相似文献
2.
Kara S. Tanaka MD Veronica R. Andaya BA Steven W. Thorpe MD Kenneth R. Gundle MD James B. Hayden MD Yee-Cheen Duong MD Raffi S. Avedian MD David G. Mohler MD Lee J. Morse MD Melissa N. Zimel MD Richard J. O'Donnell MD Andrew Fang MD Robert Lor Randall MD Tina H. Tran BS Christin New BA Rosanna L. Wustrack MD other members of Study Group FORCE 《Journal of surgical oncology》2023,127(1):148-158
3.
S. Liu A. E. Patanwala J. M. Naylor N. Levy R. Knaggs J. A. Stevens B. Bugeja D. Begley K. E. Khor E. Lau R. Allen S. Adie J. Penm 《Anaesthesia》2023,78(10):1237-1248
Modified-release opioids are often prescribed for the management of moderate to severe acute pain following total hip and knee arthroplasty, despite recommendations against their use due to increasing concerns regarding harm. The primary objective of this multicentre study was to examine the impact of modified-release opioid use on the incidence of opioid-related adverse events compared with immediate-release opioid use, among adult inpatients following total hip or knee arthroplasty. Data for total hip and knee arthroplasty inpatients receiving an opioid analgesic for postoperative analgesia during hospitalisation were collected from electronic medical records of three tertiary metropolitan hospitals in Australia. The primary outcome was the incidence of opioid-related adverse events during hospital admission. Patients who received modified with or without immediate-release opioids were matched to those receiving immediate-release opioids only (1:1) using nearest neighbour propensity score matching with patient and clinical characteristics as covariates. This included total opioid dose received. In the matched cohorts, patients given modified-release opioids (n = 347) experienced a higher incidence of opioid-related adverse events overall, compared with those given immediate-release opioids only (20.5%, 71/347 vs. 12.7%, 44/347; difference in proportions 7.8% [95%CI 2.3–13.3%]). Modified-release opioid use was associated with an increased risk of harm when used for acute pain during hospitalisation after total hip or knee arthroplasty. 相似文献
4.
Polyakova E. B. Sabirzyanov D. R. Prozorova N. A. Foteeva A. B. 《Pharmaceutical Chemistry Journal》2022,55(10):1119-1125
Pharmaceutical Chemistry Journal - Metformin hydrochloride is widely used to treat diabetes mellitus. This review presents its physical and chemical properties and discusses methods of analysis... 相似文献
5.
Khadka J. Ratcliffe J. Hutchinson C. Cleland J. Mulhern B. Lancsar E. Milte R. 《Quality of life research》2022,31(9):2849-2865
Quality of Life Research - To evaluate the construct (convergent and known group) validity of the Quality-of-Life-Aged Care Consumer (QOL-ACC), an older-person-specific quality-of-life measure... 相似文献
6.
7.
8.
Scott R. Bauer MD ScM Peggy M. Cawthon PhD MPH Kristine E. Ensrud MD Anne M. Suskind MD MS John C. Newman MD PhD Howard A. Fink MD MPH Kaiwei Lu MS Rebecca Scherzer PhD Andrew R. Hoffman MD Kenneth Covinsky MD Lynn M. Marshall ScD For the Osteoporotic Fractures in Men Research Group 《Journal of the American Geriatrics Society》2022,70(4):1082-1094
9.
10.
Silvia Radenkovic Diego Martinelli Yuebo Zhang Graeme J. Preston Arianna Maiorana Alessandra Terracciano Maria Lisa Dentici Elisa Pisaneschi Antonio Novelli Wasantha Ranatunga Anna N. Ligezka Bart Ghesquière David R. Deyle Tamas Kozicz Filippo Pinto e Vairo Peter Witters Eva Morava 《Genetics in medicine》2022,24(4):894-904
PurposeTRAPPC9 deficiency is an autosomal recessive disorder mainly associated with intellectual disability (ID), microcephaly, and obesity. Previously, TRAPPC9 deficiency has not been associated with biochemical abnormalities.MethodsExome sequencing was performed in 3 individuals with ID and dysmorphic features. N-Glycosylation analyses were performed in the patients’ blood samples to test for possible congenital disorder of glycosylation (CDG). TRAPPC9 gene, TRAPPC9 protein expression, and N-glycosylation markers were assessed in patient fibroblasts. Complementation with wild-type TRAPPC9 and immunofluorescence studies to assess TRAPPC9 expression and localization were performed. The metabolic consequences of TRAPPC9 deficiency were evaluated using tracer metabolomics.ResultsAll 3 patients carried biallelic missense variants in TRAPPC9 and presented with an N-glycosylation defect in blood, consistent with CDG type I. Extensive investigations in patient fibroblasts corroborated TRAPPC9 deficiency and an N-glycosylation defect. Tracer metabolomics revealed global metabolic changes with several affected glycosylation-related metabolites.ConclusionWe identified 3 TRAPPC9 deficient patients presenting with ID, dysmorphic features, and abnormal glycosylation. On the basis of our findings, we propose that TRAPPC9 deficiency could lead to a CDG (TRAPPC9-CDG). The finding of abnormal glycosylation in these patients is highly relevant for diagnosis, further elucidation of the pathophysiology, and management of the disease. 相似文献