全文获取类型
收费全文 | 3324篇 |
免费 | 157篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 127篇 |
妇产科学 | 29篇 |
基础医学 | 419篇 |
口腔科学 | 72篇 |
临床医学 | 214篇 |
内科学 | 796篇 |
皮肤病学 | 69篇 |
神经病学 | 388篇 |
特种医学 | 211篇 |
外科学 | 663篇 |
综合类 | 7篇 |
预防医学 | 108篇 |
眼科学 | 19篇 |
药学 | 184篇 |
中国医学 | 8篇 |
肿瘤学 | 180篇 |
出版年
2023年 | 12篇 |
2021年 | 44篇 |
2020年 | 33篇 |
2019年 | 35篇 |
2018年 | 55篇 |
2017年 | 41篇 |
2016年 | 41篇 |
2015年 | 52篇 |
2014年 | 84篇 |
2013年 | 92篇 |
2012年 | 167篇 |
2011年 | 211篇 |
2010年 | 108篇 |
2009年 | 85篇 |
2008年 | 163篇 |
2007年 | 175篇 |
2006年 | 183篇 |
2005年 | 153篇 |
2004年 | 168篇 |
2003年 | 137篇 |
2002年 | 119篇 |
2001年 | 131篇 |
2000年 | 134篇 |
1999年 | 114篇 |
1998年 | 34篇 |
1997年 | 31篇 |
1996年 | 18篇 |
1995年 | 32篇 |
1994年 | 25篇 |
1993年 | 23篇 |
1992年 | 76篇 |
1991年 | 66篇 |
1990年 | 59篇 |
1989年 | 72篇 |
1988年 | 67篇 |
1987年 | 53篇 |
1986年 | 63篇 |
1985年 | 54篇 |
1984年 | 30篇 |
1983年 | 21篇 |
1981年 | 17篇 |
1979年 | 28篇 |
1978年 | 19篇 |
1977年 | 17篇 |
1976年 | 12篇 |
1974年 | 18篇 |
1973年 | 14篇 |
1972年 | 12篇 |
1971年 | 16篇 |
1968年 | 13篇 |
排序方式: 共有3499条查询结果,搜索用时 15 毫秒
1.
2.
Shinichiro Uchiyama Takao Hoshino Leila Sissani Monteiro Tavares Linsay Kenji Kamiyama Taizen Nakase Kazuo Kitagawa Kazuo Minematsu Kenichi Todo Yasushi Okada Jyoji Nakagawara Ken Nagata Hiroshi Yamagami Takenori Yamaguchi Pierre Amarenco 《Journal of stroke and cerebrovascular diseases》2019,28(8):2232-2241
BackgroundTIAregistry.org is an international cohort of patients with transient ischemic attack (TIA) or minor stroke within 7 days before enrollment in the registry. Main analyses of 1-year follow-up data have been reported.5 We conducted subanalysis on the baseline and 1-year follow-up data of Japanese patients.MethodsThe patients were classified into 2 groups based on Japanese ethnicity, Japanese (345) and non-Japanese (3238), and their baseline data and 1-year event rates were compared. We also determined risk factors and predictors of 1-year stroke.ResultsCurrent smoking, regular alcohol drinking, intracranial arterial stenosis, and small vessel occlusion; and hypertension, dyslipidemia, coronary artery disease, and extracranial arterial stenosis were more and less common among Japanese patients, respectively. Stroke risk was higher and TIA risk was lower at 1-year follow-up among Japanese patients. The baseline risk factors for recurrent stroke were diabetes, alcohol drinking, and large artery atherosclerosis. Independent predictors of 1-year stroke risk were prior congestive heart failure and alcohol consumption.ConclusionsThe two populations of patients featured differences in risk factors, stroke subtypes, and outcome events. Predictors of recurrent stroke among Japanese patients included congestive heart failure and regular alcohol drinking. Strategies to attenuate residual risk of stroke aside from adherence to current guidelines should take our Japanese-patient specific findings into account. 相似文献
3.
4.
Kentaro Matsuo Kohei Taniguchi Hiroki Hamamoto Yosuke Inomata Kazumasa Komura Tomohito Tanaka Sang-Woong Lee Kazuhisa Uchiyama 《Cancer science》2021,112(8):2984-2992
Delta-like canonical Notch ligand 3 (DLL3) is a member of the Delta/Serrate/Lag2 (DSL) Notch receptor ligand family and plays a crucial role in Notch signaling, which influences various cellular processes including differentiation, proliferation, survival, and apoptosis. DLL3 is expressed throughout the presomitic mesoderm and is localized to the rostral somatic compartments; mutations in DLL3 induce skeletal abnormalities such as spondylocostal dysostosis. Recently, DLL3 has attracted interest as a novel molecular target due to its high expression in neuroendocrine carcinoma of the lung. Moreover, a DLL3-targeting Ab-drug conjugate, rovalpituzumab tesirine (ROVA-T), has been developed as a new treatment with proven antitumor activity. However, the development of ROVA-T was suspended because of shorter overall survival compared to topotecan, the second-line standard treatment. Thus, several studies on the mechanism and function of DLL3 in several malignancies are underway to find a new strategy for targeting DLL3. In this review, we discuss the roles of DLL3 in various malignancies and the future perspectives of DLL3-related research, especially as a therapeutic target. 相似文献
5.
6.
7.
Shumei Murakami D.D.S. Ph.D. Masami Fujishita D.D.S. Ph.D. Akira Takahashi D.D.S. Ph.D. Hideyoshi Nishiyama D.D.S. Yuka Uchiyama D.D.S. Tadashi Sasai D.D.S. Hajime Fuchihata D.D.S. Ph.D. 《Oral Radiology》1993,9(1):41-47
For patients with TMJ dysfunction, operators often change the condylar position by various methods. The aim of this study
is to investigate how much the changes with time of condylar positions are related to the changes of clinical signs.
The subjects were 584 joints of 127 patients with TMJ dysfunction to whom the serial lateral TMJ tomography was performed
more than twice.
In the most of cases where the condylar position had moved downward, inter-incisal distance had increased and TMJ noise had
ameliorated. Furthermore, in many cases where the condylar position had moved forward, the amelioration of the TMJ pain was
observed.
It was considered that those ameliorations occurred because the positional relationship between the condylar head and the
articular disk or posterior attachment had been improved. 相似文献
8.
9.
Sakamoto T Ishii T Mukai M Ueki A Sueishi K Suga K Nakano Y Uchiyama T 《The Bulletin of Tokyo Dental College》2011,52(2):103-112
Distraction osteogenesis is widely used for the treatment of craniofacial deformities. In patients with cleft lip and palate, distraction osteogenesis can be employed to repair the alveolar cleft. In this report, we describe the management of three cases of unilateral cleft lip and palate by interdental distraction osteogenesis. Interdental distraction osteogenesis of the maxillary bone was performed to reduce the width of the alveolar cleft in these patients in conjunction with orthodontic treatment. Tooth-tooth type distraction devices were fabricated and delivered at the same time as osteotomy. Distraction was continued until the midline of the dentition coincided with the facial midline, and until the width of the alveolar cleft was reduced to the width of lateral incisor or had closed. One month after distraction was complete, orthodontic treatment with an edgewise appliance was initiated, and neighboring teeth were moved into the newly created bone. A favorable treatment outcome was achieved in all three cases. 相似文献
10.
Y Mutoh Y Ohashi N Uchiyama K Terada K Hanada F Sasaki 《Journal of cranio-maxillo-facial surgery》1991,19(2):49-55
Three-dimensional surface reconstruction imaging from CT scans was used to study the deformity of the mandible in six patients with mandibular asymmetry. High-resolution axial CT scans of the mandible were obtained using Somatom-DR3 (Siemens). COSMOZONE-2SA (Nikon) with PC-9801VX21 (NEC) was used to reconstruct the three-dimensional images. The six patients were divided into two groups. One group was classified as unilateral hybrid forms and the other group was classified hemimandibular elongation on the diagnostic criteria of Obwegeser and Makek (1986). In the three-dimensional surface reconstruction, exact location and the degree of the deformity in the region from the ascending ramus to the condylar head and the lingual aspect from the ascending ramus to the mandibular body were accurately represented. In addition, the three-dimensional images could be easily rotated arbitrarily, precise evaluation could be done at every part of the mandible. On diagnosis, the mandibular morphology classified into the unilateral hybrid forms was presumed to vary from case to case even in the same classification. 相似文献