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排序方式: 共有599条查询结果,搜索用时 31 毫秒
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Gary R. Schooler Juan C. Infante Michael Acord Adina Alazraki Govind B. Chavhan James Christopher Davis Geetika Khanna Ajaykumar C. Morani Cara E. Morin HaiThuy N. Nguyen Mitchell A. Rees Raja Shaikh Abhay Srinivasan Judy H. Squires Elizabeth Tang Paul G. Thacker Alexander J. Towbin 《Pediatric blood & cancer》2023,70(Z4):e29965
Primary hepatic malignancies are relatively rare in the pediatric population, accounting for approximately 1%–2% of all pediatric tumors. Hepatoblastoma and hepatocellular carcinoma are the most common primary liver malignancies in children under the age of 5 years and over the age of 10 years, respectively. This paper provides consensus-based imaging recommendations for evaluation of patients with primary hepatic malignancies at diagnosis and follow-up during and after therapy. 相似文献
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Mitchell A. Rees Cara E. Morin Gerald G. Behr J. Christopher Davis Hollie Lai Ajaykumar C. Morani Marguerite T. Parisi Gaurav Saigal Sudha Singh Sireesha Yedururi Alexander J. Towbin Barry L. Shulkin 《Pediatric blood & cancer》2023,70(Z4):e29973
Adrenal tumors other than neuroblastoma are uncommon in children. The most frequently encountered are adrenocortical carcinoma and pheochromocytoma. This paper offers consensus recommendations for imaging of pediatric patients with a known or suspected primary adrenal malignancy other than neuroblastoma at diagnosis and during follow-up. 相似文献
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Ahmad Kaddourah Stuart L. Goldstein Steven E. Lipshultz James D. Wilkinson Lynn A. Sleeper Minmin Lu Steven D. Colan Jeffrey A. Towbin Scott I. Aydin Joseph Rossano Melanie D. Everitt Jeffrey G. Gossett Paolo Rusconi Paul F. Kantor Rakesh K. Singh John L. Jefferies 《Pediatric nephrology (Berlin, Germany)》2015,30(12):2177-2188
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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. 总被引:4954,自引:821,他引:4954 下载免费PDF全文
H Towbin T Staehelin J Gordon 《Proceedings of the National Academy of Sciences of the United States of America》1979,76(9):4350-4354
A method has been devised for the electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. The method results in quantitative transfer of ribosomal proteins from gels containing urea. For sodium dodecyl sulfate gels, the original band pattern was obtained with no loss of resolution, but the transfer was not quantitative. The method allows detection of proteins by autoradiography and is simpler than conventional procedures. The immobilized proteins were detectable by immunological procedures. All additional binding capacity on the nitrocellulose was blocked with excess protein; then a specific antibody was bound and, finally, a second antibody directed against the first antibody. The second antibody was either radioactively labeled or conjugated to fluorescein or to peroxidase. The specific protein was then detected by either autoradiography, under UV light, or by the peroxidase reaction product, respectively. In the latter case, as little as 100 pg of protein was clearly detectable. It is anticipated that the procedure will be applicable to analysis of a wide variety of proteins with specific reactions or ligands. 相似文献
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Receptor analogs and monoclonal antibodies that inhibit adherence of Bordetella pertussis to human ciliated respiratory epithelial cells 总被引:33,自引:3,他引:33 下载免费PDF全文
E Tuomanen H Towbin G Rosenfelder D Braun G Larson G C Hansson R Hill 《The Journal of experimental medicine》1988,168(1):267-277
The adherence of Bordetella pertussis to human respiratory cilia is critical to the pathogenesis of whooping cough. To explore the development of agents that could interrupt adherence, the structure of the receptor on the ciliary surface was investigated. Using an in vitro adherence assay to human ciliated epithelial cells, galactose, lactose, and complex carbohydrates containing lactose eliminated adherence when preincubated with the bacteria. 10(-2) M galactose eluted adherent bacteria from cilia. B. pertussis and its two purified adhesins bound specifically to natural lactose-containing glycolipids in a TLC assay. mAbs to eukaryotic glycoconjugates with specificity for substituted galactose-glucose moieties blocked adherence when preincubated with ciliated cells. The carbohydrates that serve as receptors for B. pertussis on human cilia are galactose-glucose-containing glycolipids. Receptor analogs and anti-receptor antibodies effectively block adherence of B. pertussis to cilia and thus should be considered candidates for therapeutic intervention against disease. 相似文献
9.
Ranjit Philip Jeffrey A. Towbin Shyam Sathanandam Jason Goldberg Thomas Yohannan Nithya Swaminathan Jason Nathaniel Johnson 《Congenital heart disease》2019,14(1):33-36
There continues to be controversy on the long‐term effects of a patent ductus arteriosus (PDA) and its management. However, the hemodynamic effects of a large PDA in a preterm infant are well known. This article aims to provide insight into the adaptive changes and remodeling effects of a PDA on the myocardium in preterm infants. 相似文献