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Cutaneous abscesses are typically incised and drained on the basis of clinical assessment. In most cases this procedure is a safe practice. We report 6 cases in which point-of-care ultrasound interrogation of obvious abscesses revealed potential serious complications with planned incision and drainage. Management was altered in 5 of 6 cases, and potential vascular disasters were avoided. In 1 case, the ultrasound results were ignored, and incision and drainage was completed, confirming the suspected abscess was indeed a solid mass later diagnosed as a carcinoma. In this case series, point-of-care ultrasound interrogation provided rapid assessment and discovery of potentially catastrophic anatomic relationships, avoiding serious complications. 相似文献
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Mathew Nelson DO FACEP Amin Abdi MD Srikar Adhikari MD MS Michael Boniface MD Robert M. Bramante MD FACEP Daniel J. Egan MD J. Matthew Fields MD Megan M. Leo MD Andrew S. Liteplo MD FACEP Rachel Liu MD FACEP FAAEM Jason T. Nomura MD FACEP FACP David C. Pigott MD RDMS FACEP Christopher C. Raio MD MBA FACEP Jennifer Ruskis MD Robert Strony DO Chris Thom MD Resa E. Lewiss MD 《Academic emergency medicine》2016,23(11):1274-1279
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Sinuff T Adhikari NK Cook DJ Schünemann HJ Griffith LE Rocker G Walter SD 《Critical care medicine》2006,34(3):878-885
OBJECTIVE: Risk-prediction models offer potential advantages over physician predictions of outcomes in the intensive care unit (ICU). Our systematic review compared the accuracy of ICU physicians' and scoring system predictions of ICU or hospital mortality of critically ill adults. DATA SOURCE: MEDLINE (1966-2005), CINAHL (1982-2005), Ovid Healthstar (1975-2004), EMBASE (1980-2005), SciSearch (1980-2005), PsychLit (1985-2004), the Cochrane Library (Issue 1, 2005), PubMed "related articles," personal files, abstract proceedings, and reference lists. STUDY SELECTION: We considered all studies that compared physician predictions of ICU or hospital survival of critically ill adults to an objective scoring system, computer model, or prediction rule. We excluded studies if they focused exclusively on the development or economic evaluation of a scoring system, computer model, or prediction rule. DATA EXTRACTION AND ANALYSIS: We independently abstracted data and assessed study quality in duplicate. We determined summary receiver operating characteristic curves and areas under the summary receiver operating characteristic curves+/-se and summary diagnostic odds ratios. DATA SYNTHESIS: We included 12 observational studies of moderate methodological quality. The area under the summary receiver operating characteristic curves for seven studies was 0.85+/-0.03 for physician predictions compared with 0.63+/-0.06 for scoring system predictions (p=.002). Physicians' summary diagnostic odds ratios derived from the area under the summary receiver operating characteristic curves were significantly higher (12.43; 95% confidence interval 5.47, 27.11) than scoring systems' summary diagnostic odds ratios (2.25; 95% confidence interval 0.78, 6.52, p=.001). Combined results of all 12 studies indicated that physicians predict mortality more accurately than do scoring systems: ratio of diagnostic odds ratios (95% confidence interval) 1.92 (1.19, 3.08) (p=.007). CONCLUSIONS: Observational studies suggest that ICU physicians discriminate between survivors and nonsurvivors more accurately than do scoring systems in the first 24 hrs of ICU admission. The overall accuracy of both predictions of patient mortality was moderate, implying limited usefulness of outcome prediction in the first 24 hrs for clinical decision making. 相似文献
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Robert A Fowler Philip Abdelmalik Gordon Wood Denise Foster Noel Gibney Natalie Bandrauk Alexis F Turgeon Fran?ois Lamontagne Anand Kumar Ryan Zarychanski Rob Green Sean M Bagshaw Henry T Stelfox Ryan Foster Peter Dodek Susan Shaw John Granton Bernard Lawless Andrea Hill Louise Rose Neill K Adhikari Damon C Scales Deborah J Cook John C Marshall Claudio Martin Philippe Jouvet 《Critical care (London, England)》2015,19(1)
IntroductionIntensive Care Units (ICUs) provide life-supporting treatment; however, resources are limited, so demand may exceed supply in the event of pandemics, environmental disasters, or in the context of an aging population. We hypothesized that comprehensive national data on ICU resources would permit a better understanding of regional differences in system capacity.MethodsAfter the 2009–2010 Influenza A (H1N1) pandemic, the Canadian Critical Care Trials Group surveyed all acute care hospitals in Canada to assess ICU capacity. Using a structured survey tool administered to physicians, respiratory therapists and nurses, we determined the number of ICU beds, ventilators, and the ability to provide specialized support for respiratory failure.ResultsWe identified 286 hospitals with 3170 ICU beds and 4982 mechanical ventilators for critically ill patients. Twenty-two hospitals had an ICU that routinely cared for children; 15 had dedicated pediatric ICUs. Per 100,000 population, there was substantial variability in provincial capacity, with a mean of 0.9 hospitals with ICUs (provincial range 0.4-2.8), 10 ICU beds capable of providing mechanical ventilation (provincial range 6–19), and 15 invasive mechanical ventilators (provincial range 10–24). There was only moderate correlation between ventilation capacity and population size (coefficient of determination (R2) = 0.771).ConclusionICU resources vary widely across Canadian provinces, and during times of increased demand, may result in geographic differences in the ability to care for critically ill patients. These results highlight the need to evolve inter-jurisdictional resource sharing during periods of substantial increase in demand, and provide background data for the development of appropriate critical care capacity benchmarks.
Electronic supplementary material
The online version of this article (doi:10.1186/s13054-015-0852-6) contains supplementary material, which is available to authorized users. 相似文献6.
Samrachana Adhikari Fabrizio Lecci James T. Becker Brian W. Junker Lewis H. Kuller Oscar L. Lopez Ryan J. Tibshirani 《Statistics in medicine》2019,38(12):2184-2205
We study regularized estimation in high-dimensional longitudinal classification problems, using the lasso and fused lasso regularizers. The constructed coefficient estimates are piecewise constant across the time dimension in the longitudinal problem, with adaptively selected change points (break points). We present an efficient algorithm for computing such estimates, based on proximal gradient descent. We apply our proposed technique to a longitudinal data set on Alzheimer's disease from the Cardiovascular Health Study Cognition Study. Using data analysis and a simulation study, we motivate and demonstrate several practical considerations such as the selection of tuning parameters and the assessment of model stability. While race, gender, vascular and heart disease, lack of caregivers, and deterioration of learning and memory are all important predictors of dementia, we also find that these risk factors become more relevant in the later stages of life. 相似文献
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Hiroshi Mitoma Keya Adhikari Daniel Aeschlimann Partha Chattopadhyay Marios Hadjivassiliou Christiane S. Hampe Jérôme Honnorat Shinji Kakei Jongho Lee Mario Manto Akiko Matsunaga Hidehiro Mizusawa Kazunori Nanri Priya Shanmugarajah Makoto Yoneda Nobuhiro Yuki 《Cerebellum (London, England)》2016,15(2):213-232
In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto’s encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias. 相似文献
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Bhim M. Adhikari Juergen Dukart Joerg F. Hipp Anna Forsyth Rebecca McMillan Suresh D. Muthukumaraswamy Meghann C. Ryan L. Elliot Hong Simon B. Eickhoff Neda Jahandshad Paul M. Thompson Laura M. Rowland Peter Kochunov 《Human brain mapping》2020,41(3):767-778
Subanesthetic administration of ketamine is a pharmacological model to elicit positive and negative symptoms of psychosis in healthy volunteers. We used resting‐state pharmacological functional MRI (rsPhfMRI) to identify cerebral networks affected by ketamine and compared them to the functional connectivity (FC) in schizophrenia. Ketamine can produce sedation and we contrasted its effects with the effects of the anxiolytic drug midazolam. Thirty healthy male volunteers (age = 19–37 years) underwent a randomized, three‐way, cross‐over study consisting of three imaging sessions, with 48 hr between sessions. A session consisted of a control period followed by infusion of placebo or ketamine or midazolam. The ENIGMA rsfMRI pipeline was used to derive two long‐distance (seed‐based and dual‐regression) and one local (regional homogeneity, ReHo) FC measures. Ketamine induced significant reductions in the connectivity of the salience network (Cohen's d: 1.13 ± 0.28, p = 4.0 × 10?3), auditory network (d: 0.67 ± 0.26, p = .04) and default mode network (DMN, d: 0.63 ± 0.26, p = .05). Midazolam significantly reduced connectivity in the DMN (d: 0.77 ± 0.27, p = .03). The effect sizes for ketamine for resting networks showed a positive correlation (r = .59, p = .07) with the effect sizes for schizophrenia‐related deficits derived from ENIGMA's study of 261 patients and 327 controls. Effect sizes for midazolam were not correlated with the schizophrenia pattern (r = ?.17, p = .65). The subtraction of ketamine and midazolam patterns showed a significant positive correlation with the pattern of schizophrenia deficits (r = .68, p = .03). RsPhfMRI reliably detected the shared and divergent pharmacological actions of ketamine and midazolam on cerebral networks. The pattern of disconnectivity produced by ketamine was positively correlated with the pattern of connectivity deficits observed in schizophrenia, suggesting a brain functional basis for previously poorly understood effects of the drug. 相似文献