全文获取类型
收费全文 | 16473篇 |
免费 | 1060篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 164篇 |
儿科学 | 628篇 |
妇产科学 | 670篇 |
基础医学 | 2015篇 |
口腔科学 | 230篇 |
临床医学 | 2737篇 |
内科学 | 2743篇 |
皮肤病学 | 343篇 |
神经病学 | 1380篇 |
特种医学 | 264篇 |
外科学 | 1497篇 |
综合类 | 305篇 |
一般理论 | 17篇 |
预防医学 | 2046篇 |
眼科学 | 361篇 |
药学 | 1008篇 |
中国医学 | 20篇 |
肿瘤学 | 1125篇 |
出版年
2023年 | 100篇 |
2022年 | 78篇 |
2021年 | 331篇 |
2020年 | 301篇 |
2019年 | 398篇 |
2018年 | 422篇 |
2017年 | 314篇 |
2016年 | 355篇 |
2015年 | 411篇 |
2014年 | 557篇 |
2013年 | 825篇 |
2012年 | 1293篇 |
2011年 | 1401篇 |
2010年 | 736篇 |
2009年 | 592篇 |
2008年 | 1179篇 |
2007年 | 1223篇 |
2006年 | 1136篇 |
2005年 | 1158篇 |
2004年 | 1100篇 |
2003年 | 1053篇 |
2002年 | 846篇 |
2001年 | 107篇 |
2000年 | 87篇 |
1999年 | 87篇 |
1998年 | 146篇 |
1997年 | 136篇 |
1996年 | 89篇 |
1995年 | 91篇 |
1994年 | 93篇 |
1993年 | 84篇 |
1992年 | 62篇 |
1991年 | 60篇 |
1990年 | 58篇 |
1989年 | 56篇 |
1988年 | 43篇 |
1987年 | 35篇 |
1986年 | 50篇 |
1985年 | 42篇 |
1984年 | 62篇 |
1983年 | 51篇 |
1982年 | 54篇 |
1981年 | 42篇 |
1980年 | 48篇 |
1979年 | 33篇 |
1978年 | 28篇 |
1977年 | 20篇 |
1976年 | 14篇 |
1974年 | 13篇 |
1972年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 109 毫秒
1.
2.
Sharon Elad DMD MSc Noam Yarom DMD Yehuda Zadik DMD MHA Michal Kuten-Shorrer DMD DMSc Stephen T. Sonis DMD DMSc 《CA: a cancer journal for clinicians》2022,72(1):57-77
Oral mucositis (OM) is a common, highly symptomatic complication of cancer therapy that affects patients' function, quality of life, and ability to tolerate treatment. In certain patients with cancer, OM is associated with increased mortality. Research on the management of OM is ongoing. Oral mucosal toxicities are also reported in targeted and immune checkpoint inhibitor therapies. The objective of this article is to present current knowledge about the epidemiology, pathogenesis, assessment, risk prediction, and current and developing intervention strategies for OM and other ulcerative mucosal toxicities caused by both conventional and evolving forms of cancer therapy. 相似文献
3.
Loren Saulsberry PhD Ankur Bhargava MD MPH Sharon Zeng BA Jason B. Gibbons PhD Cody Brannan MS Diane S. Lauderdale PhD Robert D. Gibbons PhD 《Health services research》2023,58(4):873-881
Objective
To derive and validate a new ecological measure of the social determinants of health (SDoH), calculable at the zip code or county level.Data Sources and Study Setting
The most recent releases of secondary, publicly available data were collected from national U.S. health agencies as well as state and city public health departments.Study Design
The Social Vulnerability Metric (SVM) was constructed from U.S. zip-code level measures (2018) from survey data using multidimensional Item Response Theory and validated using outcomes including all-cause mortality (2016), COVID-19 vaccination (2021), and emergency department visits for asthma (2018). The SVM was also compared with the existing Centers for Disease Control and Prevention's Social Vulnerability Index (SVI) to determine convergent validity and differential predictive validity.Data Collection/Extraction Methods
The data were collected directly from published files available to the public online from national U.S. health agencies as well as state and city public health departments.Principal Findings
The correlation between SVM scores and national age-adjusted county all-cause mortality was r = 0.68. This correlation demonstrated the SVM's robust validity and outperformed the SVI with an almost four-fold increase in explained variance (46% vs. 12%). The SVM was also highly correlated (r ≥ 0.60) to zip-code level health outcomes for the state of California and city of Chicago.Conclusions
The SVM offers a measurement tool improving upon the performance of existing SDoH composite measures and has broad applicability to public health that may help in directing future policies and interventions. The SVM provides a single measure of SDoH that better quantifies associations with health outcomes. 相似文献4.
5.
Dal Canto Elisa Remmelzwaal Sharon van Ballegooijen Adriana Johanne Handoko M. Louis Heymans Stephane van Empel Vanessa Paulus Walter J. Nijpels Giel Elders Petra Beulens Joline WJ 《Heart failure reviews》2022,27(1):207-218
Heart Failure Reviews - This study aimed to evaluate the diagnostic performance of echocardiographic markers of heart failure with preserved ejection fraction (HFpEF) and left ventricular diastolic... 相似文献
6.
Amir Hossein Saeidian Leila Youssefian Jianhe Huang Andrew Touati Hassan Vahidnezhad Luke Kowal Matthew Caffet Tamara Wurst Jagmohan Singh Adam E. Snook Ellen Ryu Paolo Fortina Sharon F. Terry Jonathan G. Schoenecker Jouni Uitto Qiaoli Li 《Genetics in medicine》2022,24(1):75-86
PurposeHeritable ectopic mineralization disorders comprise a group of conditions with a broad range of clinical manifestations in nonskeletal connective tissues. We report the genetic findings from a large international cohort of 478 patients afflicted with ectopic mineralization.MethodsSequence variations were identified using a next-generation sequencing panel consisting of 29 genes reported in association with ectopic mineralization. The pathogenicity of select splicing and missense variants was analyzed in experimental systems in vitro and in vivo.ResultsA total of 872 variants of unknown significance as well as likely pathogenic and pathogenic variants were disclosed in 25 genes. A total of 159 distinct variants were identified in 425 patients in ABCC6, the gene responsible for pseudoxanthoma elasticum, a heritable multisystem ectopic mineralization disorder. The interpretation of variant pathogenicity relying on bioinformatic predictions did not provide a consensus. Our in vitro and in vivo functional assessment of 14 ABCC6 variants highlighted this dilemma and provided unambiguous interpretations to their pathogenicity.ConclusionThe results expand the ABCC6 variant repertoire, shed new light on the genetic heterogeneity of heritable ectopic mineralization disorders, and provide evidence that functional characterization in appropriate experimental systems is necessary to determine the pathogenicity of genetic variants. 相似文献
7.
Oliver A. Cornely Martin Hoenigl Cornelia Lass‐Flrl Sharon C. ‐A. Chen Dimitrios P. Kontoyiannis C. Orla Morrissey George R. Thompson 《Mycoses》2019,62(9):716-729
Breakthrough invasive fungal infections (IFIs) have emerged as a significant problem in patients receiving systemic antifungals; however, consensus criteria for defining breakthrough IFI are missing. This position paper establishes broadly applicable definitions of breakthrough IFI for clinical research. Representatives of the Mycoses Study Group Education and Research Consortium (MSG‐ERC) and the European Confederation of Medical Mycology (ECMM) reviewed the relevant English literature for definitions applied and published through 2018. A draft proposal for definitions was developed and circulated to all members of the two organisations for comment and suggestions. The authors addressed comments received and circulated the updated document for approval. Breakthrough IFI was defined as any IFI occurring during exposure to an antifungal drug, including fungi outside the spectrum of activity of an antifungal. The time of breakthrough IFI was defined as the first attributable clinical sign or symptom, mycological finding or radiological feature. The period defining breakthrough IFI depends on pharmacokinetic properties and extends at least until one dosing interval after drug discontinuation. Persistent IFI describes IFI that is unchanged/stable since treatment initiation with ongoing need for antifungal therapy. It is distinct from refractory IFI, defined as progression of disease and therefore similar to non‐response to treatment. Relapsed IFI occurs after treatment and is caused by the same pathogen at the same site, although dissemination can occur. These proposed definitions are intended to support the design of future clinical trials and epidemiological research in clinical mycology, with the ultimate goal of increasing the comparability of clinical trial results. 相似文献
8.
Jeffrey N. Weitzel MD Susan L. Neuhausen PhD Aaron Adamson PhD Shu Tao PhD Charité Ricker MS Asaf Maoz MD Margalit Rosenblatt BA Bita Nehoray MS Sharon Sand BA Linda Steele MS Gary Unzeitig MD Nancy Feldman MD Amie M. Blanco MS Donglei Hu PhD Scott Huntsman MS Danielle Castillo BS Christopher Haiman ScD Thomas Slavin MD Elad Ziv MD 《Cancer》2019,125(16):2829-2836
9.
Chi Andrew S. Tarapore Rohinton S. Hall Matthew D. Shonka Nicole Gardner Sharon Umemura Yoshie Sumrall Ashley Khatib Ziad Mueller Sabine Kline Cassie Zaky Wafik Khatua Soumen Weathers Shiao-Pei Odia Yazmin Niazi Toba N. Daghistani Doured Cherrick Irene Korones David Karajannis Matthias A. Kong Xiao-Tang Minturn Jane Waanders Angela Arillaga-Romany Isabel Batchelor Tracy Wen Patrick Y. Merdinger Krystal Schalop Lee Stogniew Martin Allen Joshua E. Oster Wolfgang Mehta Minesh P. 《Journal of neuro-oncology》2019,144(1):97-105
Journal of Neuro-Oncology - Smoking is agreed to be a major health risk factor, but it is debated whether it has an influence on perioperative adverse events (AEs) in elective cranial tumor... 相似文献
10.
Konstantinos Chouliaras MD Rebecca Senehi MD Cecilia G. Ethun MD MS George Poultsides MD Thuy Tran MD Valerie Grignol MD Thomas Clark Gamblin MD Kevin K. Roggin MD Jennifer Tseng MD Ryan C. Fields MD Sharon M. Weber MD Gregory B. Russell MS Edward A. Levine MD Kenneth Cardona MD Konstantinos Votanopoulos MD 《Journal of surgical oncology》2019,120(3):340-347