全文获取类型
收费全文 | 929篇 |
免费 | 60篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 127篇 |
儿科学 | 38篇 |
妇产科学 | 6篇 |
基础医学 | 53篇 |
口腔科学 | 34篇 |
临床医学 | 72篇 |
内科学 | 129篇 |
皮肤病学 | 17篇 |
神经病学 | 10篇 |
特种医学 | 106篇 |
外科学 | 189篇 |
综合类 | 27篇 |
预防医学 | 33篇 |
眼科学 | 5篇 |
药学 | 29篇 |
中国医学 | 1篇 |
肿瘤学 | 120篇 |
出版年
2021年 | 9篇 |
2020年 | 11篇 |
2019年 | 7篇 |
2018年 | 18篇 |
2017年 | 8篇 |
2016年 | 18篇 |
2015年 | 24篇 |
2014年 | 33篇 |
2013年 | 42篇 |
2012年 | 48篇 |
2011年 | 37篇 |
2010年 | 44篇 |
2009年 | 37篇 |
2008年 | 34篇 |
2007年 | 30篇 |
2006年 | 51篇 |
2005年 | 24篇 |
2004年 | 28篇 |
2003年 | 33篇 |
2002年 | 51篇 |
2001年 | 36篇 |
2000年 | 14篇 |
1999年 | 25篇 |
1998年 | 36篇 |
1997年 | 23篇 |
1996年 | 22篇 |
1995年 | 17篇 |
1994年 | 23篇 |
1993年 | 29篇 |
1992年 | 11篇 |
1991年 | 13篇 |
1990年 | 9篇 |
1989年 | 18篇 |
1988年 | 22篇 |
1987年 | 10篇 |
1986年 | 17篇 |
1985年 | 7篇 |
1984年 | 12篇 |
1983年 | 6篇 |
1982年 | 9篇 |
1981年 | 12篇 |
1980年 | 12篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1976年 | 10篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1957年 | 1篇 |
1955年 | 1篇 |
1939年 | 1篇 |
排序方式: 共有996条查询结果,搜索用时 218 毫秒
1.
2.
3.
4.
GT Terézhalmy AR Biesbrock PA Walters JM Grender RD Bartizek 《International journal of dental hygiene》2008,6(4):321-327
Abstract: Aim: To compare plaque removal efficacy of Oral‐B CrossAction (CA) used for 1 min with an American Dental Association (ADA) manual toothbrush used for 2 or 5 min in an examiner‐blind, three‐treatment, six‐period crossover study. Materials and methods: After refraining from all oral hygiene procedures for 23–25 h, subjects were randomly assigned to one of nine possible six‐period (visit) treatment sequences. Plaque was assessed at baseline (Rustogi Modified Navy Plaque Index). Post‐brushing scores were recorded after brushing with a marketed dentifrice and the assigned toothbrush for the specified duration. The same procedure was followed at each of six subsequent visits. Clinical measurements were carried out by the same examiner. Results: Forty subjects completed the study. All three treatments effectively removed plaque from the whole mouth, along the gingival margin and from approximal surfaces. Whole mouth and gingival margin plaque removal scores with CA for 1 min did not differ significantly from scores with the ADA toothbrush used for 2 min. The ADA brush used for 5 min showed significantly greater whole mouth (P < 0.001) and gingival margin (P < 0.001) plaque reduction than the two other treatments. Approximal plaque removal scores did not differ between the three treatments. Conclusions: Efficient plaque removal can be achieved after 1 min of brushing with CA. The amount of plaque removed did not differ significantly from that achieved with the ADA brush after 2 min of brushing. Greater whole mouth and gingival margin plaque removal scores were seen with the ADA brush after 5 min. 相似文献
5.
Mary Murray-Weir PT MBA Steven Magid MD CMIO Laura Robbins DSW Patricia Quinlan PhD MPA RN CPHQ Pamela Sanchez-Villagomez MPA Steven H. Shaha PhD DBA 《HSS journal》2014,10(1):52-58
Background
Computerized provider order entry (CPOE) has been considered essential for the reduction of medical errors and increased patient safety. Assessment of staff perception regarding a CPOE system is important for satisfaction and adoption. Incorporation of user feedback can greatly improve the functionality of a system and promote user satisfaction.Questions/Purposes
This study aims to develop an informatics staff satisfaction survey instrument and to understand what components of computerized prescriber order entry (CPOE) contribute to staff satisfaction and its variability over time.Methods
The 22-question survey was developed by a multidisciplinary group and focused on patient data including demographics, orders, medications, laboratory, and radiology data. The questions were designed to understand if clinicians (1) could easily access the information needed to properly take care of patients, (2) could act upon the information once acquired, (3) could obtain the information clearly, and (4) were alerted to potential errors. The survey was distributed just prior to “go-live,” 6 and 12 months after go-live. Responses were given on a five-point Likert scale.Results
The survey results post-implementation showed user satisfaction with CPOE. Satisfaction regarding the ease of obtaining orders, medication, and lab data had a significant improvement at 6 and 12 months post-implementation, p < 0.001. Satisfaction that the computerized order entry system provided information needed to take care of their patients improved, p < 0.01. At 1 year post-implementation, user satisfaction declined from 6 months earlier but still demonstrated an overall increase in satisfaction from pre-implementation.Conclusion
Compared prior to go-live, clinicians are satisfied or very satisfied across multiple spheres and multiple disciplines. At all time points, clinicians were able to obtain information required to take care of their patients. However, post-go-live, it was easier to obtain and act upon as well as more clear and understandable.Electronic supplementary material
The online version of this article (doi:10.1007/s11420-013-9377-1) contains supplementary material, which is available to authorized users. 相似文献6.
DK Bilku AR Dennison TC Hall MS Metcalfe G Garcea 《Annals of the Royal College of Surgeons of England》2014,96(1):15-22
INTRODUCTION
Surgical stress in the presence of fasting worsens the catabolic state, causes insulin resistance and may delay recovery. Carbohydrate rich drinks given preoperatively may ameliorate these deleterious effects. A systematic review was undertaken to analyse the effect of preoperative carbohydrate loading on insulin resistance, gastric emptying, gastric acidity, patient wellbeing, immunity and nutrition following surgery.METHODS
All studies identified through PubMed until September 2011 were included. References were cross-checked to ensure capture of cited pertinent articles.RESULTS
Overall, 17 randomised controlled trials with a total of 1,445 patients who met the inclusion criteria were identified. Preoperative carbohydrate drinks significantly improved insulin resistance and indices of patient comfort following surgery, especially hunger, thirst, malaise, anxiety and nausea. No definite conclusions could be made regarding preservation of muscle mass. Following ingestion of carbohydrate drinks, no adverse events such as apparent or proven aspiration during or after surgery were reported.CONCLUSIONS
Administration of oral carbohydrate drinks before surgery is probably safe and may have a positive influence on a wide range of perioperative markers of clinical outcome. Further studies are required to determine its cost effectiveness. 相似文献7.
J Isherwood G Garcea R Williams M Metcalfe AR Dennison 《Annals of the Royal College of Surgeons of England》2014,96(3):224-228
Introduction
Magnetic resonance cholangiopancreatography (MRCP) is not a routine investigation to exclude choledocholithiasis unless there is clinical or biochemical suspicion of common bile duct (CBD) stones. This study attempted to determine which radiological or serological parameters best predicted CBD stones.Methods
All patients undergoing MRCP from 2005 to 2011 were selected. Patients with pancreatitis were excluded. Liver function tests (LFTs) at admission and prior to MRCP were recorded, as was abdominal ultrasonography and MRCP results. Parameters measured routinely on LFTs included alkaline phosphatase (ALP), alanine transaminase (ALT) and bilirubin. Receiver operating characteristic curve area analysis (area under the curve [AUC]) and chi-squared analysis were undertaken.Results
Overall, 195 patients were identified, 71 of whom had CBD stones on MRCP. Raised ALP levels on admission demonstrated a correlation with CBD stones (AUC: 0.619, odds ratio [OR]: 3.16, p=0.06). At ultrasonography, a dilated CBD (OR: 3.76, p<0.001) and intrahepatic duct dilation (OR: 5.56, p<0.001) were highly significant predictors. However, only 37% of patients had a dilated CBD on ultrasonography. Ongoing elevation of LFT parameters, particularly ALP (AUC: 0.707, OR: 4.64, p<0.001) and ALT (AUC: 0.646, OR: 5.40, p<0.001), displayed a significant correlation with CBD stones.Conclusions
Ongoing (even if minor) elevations of liver function test parameters should prompt the need to exclude CBD stones even in the presence of a normal CBD diameter on ultrasonography. 相似文献8.
Temporal artery biopsy is considered the gold standard investigation of giant cell arteritis and is recommended in suspected cases despite a sensitivity of 81–91%. This review highlights the potential risk of facial nerve injury during temporal artery biopsy and introduces recent advances in the emerging role of imaging modalities. When these non-invasive techniques are used in conjunction with American College of Rheumatology scoring, which includes clinical features and biochemical test results, temporal artery biopsy may be avoided in selected cases. 相似文献
9.
Image‐guided chemical and thermal ablations for thyroid disease: Review of efficacy and complications 下载免费PDF全文
Iain J. Nixon MBChB PhD Peter Angelos MD PhD Ashok R. Shaha MD Michelle D. Williams MD 《Head & neck》2018,40(9):2103-2115
Image‐guided ablation of thyroid disease is increasingly being commonly reported. Techniques including ethanol injection and thermal ablation using radio‐frequency, laser, and microwave devices have been described. Minimally invasive approaches to the management of benign cystic, solid, and functional thyroid nodules as well as both primary and recurrent thyroid malignancy have been reported. The purpose of this article is to review the current evidence relating to image‐guided ablation of thyroid disease with a focus on clinical outcomes and complication rates for patients treated with this minimally invasive approach. 相似文献
10.
Hyperbaric oxygen therapy improves angiogenesis and bone formation in critical sized diaphyseal defects 下载免费PDF全文
JP Grassmann J Schneppendahl AR Hakimi M Herten M Betsch TT Lögters S Thelen M Sager M Wild J Windolf P Jungbluth M Hakimi 《Journal of orthopaedic research》2015,33(4):513-520
Besides the use of autologous bone grafting several osteoconductive and osteoinductive methods have been reported to improve bone healing. However, persistent non‐union occurs in a considerable number of cases and compromised angiogenesis is suspected to impede bone regeneration. Hyperbaric oxygen therapy (HBO) improves angiogenesis. This study evaluates the effects of HBO on bone defects treated with autologous bone grafting in a bone defect model in rabbits. Twenty‐four New‐Zealand White Rabbits were subjected to a unilateral critical sized diaphyseal radius bone defect and treated with autologous cancellous bone transplantation. The study groups were exposed to an additional HBO treatment regimen. Bone regeneration was evaluated radiologically and histologically at 3 and 6 weeks, angiogenesis was assessed by immunohistochemistry at three and six weeks. The additional administration of HBO resulted in a significantly increased new bone formation and angiogenesis compared to the sole treatment with autologous bone grafting. These results were apparent after three and six weeks of treatment. The addition of HBO therapy to autologous bone grafts leads to significantly improved bone regeneration. The increase in angiogenesis observed could play a crucial role for the results observed. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:513–520, 2015. 相似文献