全文获取类型
收费全文 | 432篇 |
免费 | 42篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 15篇 |
妇产科学 | 12篇 |
基础医学 | 42篇 |
口腔科学 | 23篇 |
临床医学 | 55篇 |
内科学 | 92篇 |
皮肤病学 | 12篇 |
神经病学 | 28篇 |
特种医学 | 81篇 |
外科学 | 30篇 |
综合类 | 7篇 |
预防医学 | 20篇 |
眼科学 | 6篇 |
药学 | 46篇 |
中国医学 | 2篇 |
肿瘤学 | 7篇 |
出版年
2023年 | 6篇 |
2022年 | 4篇 |
2021年 | 9篇 |
2020年 | 14篇 |
2019年 | 7篇 |
2018年 | 18篇 |
2017年 | 19篇 |
2016年 | 21篇 |
2015年 | 15篇 |
2014年 | 8篇 |
2013年 | 17篇 |
2012年 | 25篇 |
2011年 | 20篇 |
2010年 | 11篇 |
2009年 | 17篇 |
2008年 | 22篇 |
2007年 | 14篇 |
2006年 | 9篇 |
2005年 | 12篇 |
2004年 | 3篇 |
2003年 | 4篇 |
2002年 | 5篇 |
2000年 | 6篇 |
1999年 | 5篇 |
1998年 | 7篇 |
1997年 | 13篇 |
1996年 | 11篇 |
1995年 | 12篇 |
1994年 | 17篇 |
1993年 | 16篇 |
1992年 | 2篇 |
1991年 | 7篇 |
1990年 | 7篇 |
1989年 | 14篇 |
1988年 | 14篇 |
1987年 | 6篇 |
1986年 | 3篇 |
1985年 | 14篇 |
1984年 | 3篇 |
1983年 | 9篇 |
1982年 | 4篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 6篇 |
1975年 | 3篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1968年 | 2篇 |
排序方式: 共有480条查询结果,搜索用时 312 毫秒
1.
Salarinasab Sadegh Salimi Leila Alidadiani Neda Shokrollahi Elhameh Arzhanga Pishva Karbasforush Saedeh Marofi Faroogh Nasirzadeh Mahdieh Rahbarghazi Reza Nourazarian Alireza Nikanfar Masoud 《Journal of molecular neuroscience : MN》2020,70(6):819-834
Journal of Molecular Neuroscience - Alzheimer's disease is associated with biochemical and histopathological changes characterized by molecular abnormalities. Due to the lack of effective... 相似文献
2.
Yahya Khosravi Ahmad Salimi Jalal Pourahmad 《Xenobiotica; the fate of foreign compounds in biological systems》2018,48(8):860-866
1. Today, diamond nanoparticles have several industrial applications. Nano diamond (ND) as a carbon allotrope diffuses in the air easily during producing and processing procedures.2. In this study, we investigated sub-acute exposed to ND at the exposure chamber in mice. The animals were divided into two groups (control and exposed group to ND at the concentration of 3?µg/m3 for 3?h/day, 5?days/week for 30?days) in a whole-body inhalation chamber.3. Our results showed that exposure to ND induced the hematological and biochemical changes. The target organs for ND were the lungs, brain and heart in the mice, respectively. Also, ND increased reactive oxygen species (ROS) generation, lipid peroxidation (LPO), the collapse of mitochondrial membrane potential (MMP), decreased a level of reduced glutathione (GSH) and finally increased a level of glutathione disulfide (GSSG) in lung, brain and heart tissues. Our results suggest that exposure to ND can induce oxidative stress in the tissue mentioned.4. These results suggest that exposure of researchers and workers with diamond nanoparticles probably increase a risk of respiratory, cardiovascular and cerebral disorders through oxidative stress. However, good ventilation, appropriate personal protective equipment and using of anti-oxidant compounds in daily diet of worker are suggested. 相似文献
3.
Alireza Tahamtan Fatemeh Sana Askari Louis Bont Vahid Salimi 《Reviews in medical virology》2019,29(2)
Respiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis and pneumonia in the pediatric population worldwide. The immunopathology of RSV infection varies considerably and severe disease occurs only in a minority of the population. There are many factors (host, viral, and environmental) that contribute to the complicated disease phenotype. In this regard, host factors are decisive for pulmonary susceptibility to RSV infection. Host genetic diversity certainly affects the balance between control of viral replication and tissue damage during RSV infection, consequently impacting on diseases outcome. In this review, we discuss the role of host genetic variation in disease caused by RSV aiming to highlight genetic risk factors for one of the most common diseases in early childhood. Our findings clearly indicate that the response of each individual to infection is influenced by genetic diversity mainly linked to the regulation of host immune responses. Future genetic association and functional studies using more powerful and consistently reproducible approaches will likely be able to confirm, refine, and expand our developing concept of RSV disease pathogenesis. 相似文献
4.
The dental implications of bisphosphonates and bone disease 总被引:3,自引:0,他引:3
5.
NL Vasukutty RG Middleton P Young C Uzoigwe B Barkham S Yusoff THA Minhas 《Annals of the Royal College of Surgeons of England》2014,96(8):597-601
IntroductionDislocation following total hip replacement continues to be a problem for which no completely satisfactory solution has been found. Several methods have been proposed to reduce the incidence of hip dislocations with varying degrees of success, including elevated rim liners, constrained liners and large diameter bearings. We present our experience with the double mobility acetabular component in patients at high risk of instability.MethodsThis was a retrospective review of 65 primary total hip arthroplasties in 55 patients (15 men, 40 women), performed between October 2005 and November 2009. The majority (80%) of patients had at least two and 26% had at least three risk factors for instability. The mean age was 76 years (range: 44–92 years). The patients were followed up for a mean duration of 60 months (range: 36–85 months).ResultsFourteen patients died and one was lost to follow-up, leaving fifty hips for final assessment. Until the final follow-up appointment, no patients had dislocation and none required revision surgery. The mean Oxford hip score improved from 45.0 to 26.5 (p<0.0001). The mean Merle d’Aubigné pain score improved from 1.4 to 4.9 (p<0.0001), the walking score from 2.3 to 3.1 (p<0.07) and the absolute hip function score from 5.4 to 10.8 (p<0.0001). There were no clinical or radiographic signs of loosening.ConclusionsThe double mobility acetabular component was successful at preventing dislocation during early to medium-term follow-up. However, as data are still lacking with regard to polyethylene wear rates at the additional bearing surface, it would be prudent to restrict the use of this implant to selected patients at high risk of instability. 相似文献
6.
Soluble Tumor Necrosis Factor Alpha Receptor 1, Bone Resorption,and Bone Mineral Density in the Year Following Hip Fractures: The Baltimore Hip Studies 下载免费PDF全文
7.
Mohsen Shahrousvand Ali Salimi 《Journal of biomaterials science. Polymer edition》2016,27(17):1712-1728
The cells as a tissue component need to viscoelastic, biocompatible, biodegradable, and wettable extracellular matrix for their biological activity. In this study, in order to prepare biomedical polyurethane elastomers with good mechanical behavior and biodegradability, a series of novel polyester–polyether- based polyurethanes (PUs) were synthesized using a two-step bulk reaction by melting pre-polymer method, taking 1,4-Butanediol (BDO) as chain extender, hexamethylene diisocyanate as the hard segment, and poly (tetramethylene ether) glycol (PTMEG) and poly (ε-caprolactone diol) (PCL-Diol) as the soft segment without a catalyst. The soft to the hard segment ratio was kept constant in all samples. Polyurethane characteristics such as thermal and mechanical properties, wettability and water adsorption, biodegradability, and cellular behavior were changed by changing the ratio of polyether diol to polyester diol composition in the soft segment. Our present work provides a new procedure for the preparation of engineered polyurethanes in surface properties and biodegradability, which could be a good candidate for bone, cartilage, and skin tissue engineering. 相似文献
8.
9.
Mohammad Jafferany Sohrab Salimi Ruzanna Mkhoyan Natalia Kalashnikova Roxanna Sadoughifar Etleva Jorgaqi 《Dermatologic therapy》2020,33(4)
Recently there is a surge in cosmetic and aesthetic surgery procedures. Several patient seeking various cosmetics procedures present to aesthetic surgery clinics and demanding procedures which are out of proportion. Several of these patients have under‐recognized or untreated psychiatric disorders. Proper screening and evaluation of these patients could save money and resources. This brief review focuses on current trends, clinical and psychological assessment and expectations on the part of patients and recommendations regarding management of these patients. 相似文献
10.
Reza Fekrazad Khojasteh Joharchi Katayoun AM Kalhori Fatemeh Mashhadi Abbas Fariborz Salimi Vahid 《Journal of cosmetic and laser therapy》2017,19(4):232-236
Introduction: One of the most important innovative methods for tissue repair promotion is therapeutic lasers with photobiomodulution effects. The aim of this study was to investigate the effect of four different wavelengths of therapeutic laser (405, 532, 660 and 810 nm) on healing of third-degree burns from both clinical and pathological standpoints in rats. Materials and methods: 60 male Wistar rats were used. Animals were anesthetized and dorsal hairs were shaved and third-degree skin burns were created by use of a 95°C copper stamp. Lesions were irradiated with 1.5 J/cm2 energy densities and 200 mW/cm2 power densities. Results: Statistical analyses of the “wound contraction” changes between five groups during the study showed more reduction in wound size in all laser groups in comparison with the control group; but these differences were not statistically significant except between red and blue lasers on the last day of experiment. Discussion: Results of our study showed that using therapeutic lasers with green, blue, red, and infrared wavelengths may accelerate healing process. This trend is more obvious in red and infrared groups especially after acute phase, however, this effect was neither statistically nor clinically significant. 相似文献