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1.
Rolf Svedjeholm Gabriele Ferrari Farkas Vanky Örjan Friberg Jonas Holm 《Acta anaesthesiologica Scandinavica》2023,67(10):1373-1382
Background
Glutamate plays a key role for post-ischaemic recovery of myocardial metabolism. According to post hoc analyses of the two GLUTAMICS trials, patients without diabetes benefit from glutamate with less myocardial dysfunction after coronary artery bypass surgery (CABG). Copeptin reflects activation of the Arginine Vasopressin system and is a reliable marker of heart failure but available studies in cardiac surgery are limited. We investigated whether glutamate infusion is associated with reduced postoperative rises of plasma Copeptin (p-Copeptin) after CABG.Methods
A prespecified randomised double-blind substudy of GLUTAMICS II. Patients had left ventricular ejection fraction ≤0.30 or EuroSCORE II ≥3.0 and underwent CABG ± valve procedure. Intravenous infusion of 0.125 M L-glutamic acid or saline at 1.65 mL/kg/h was commenced 10–20 min before the release of the aortic cross-clamp and then continued for another 150 min P-Copeptin was measured preoperatively and postoperatively on day one (POD1) and day three. The primary endpoint was an increase in p-Copeptin from the preoperative level to POD1. Postoperative stroke ≤24 h and mortality ≤30 days were safety outcomes.Results
We included 181 patients of whom 48% had diabetes. The incidence of postoperative mortality ≤30 days (0% vs. 2.1%; p = .50) and stroke ≤24 h (0% vs. 3.2%; p = .25) did not differ between the glutamate group and controls. P-Copeptin increased postoperatively with the highest values recorded on POD1 without significant inter-group differences. Among patients without diabetes, p-Copeptin did not differ preoperatively but postoperative rise from preoperative level to POD1 was significantly reduced in the glutamate group (73 ± 66 vs. 115 ± 102 pmol/L; p = .02). P-Copeptin was significantly lower in the Glutamate group on POD1 (p = .02) and POD 3 (p = .02).Conclusions
Glutamate did not reduce rises of p-Copeptin significantly after moderate to high-risk CABG. However, glutamate was associated with reduced rises of p-Copeptin among patients without diabetes. These results agree with previous observations suggesting that glutamate mitigates myocardial dysfunction after CABG in patients without diabetes. Given the exploratory nature of these findings, they need to be confirmed in future studies. 相似文献2.
Paula Pessin Fábrega Branisso Claudia Pinto Marques Souza de Oliveira Hilton Muniz Leão Filho Fabiana Roberto Lima Aritânia Sousa Santos Marcio Correa Mancini Maria Edna de Melo Flair José Carrilho Manoel de Souza Rocha Paul Clark Henrique José Pereira Branisso Cintia Cercato 《Annals of hepatology》2022,27(4):100707
IntroductionAlthough hyperferritinemia may reflect the inflammatory status of patients with non-alcoholic fatty liver disease (NAFLD), approximately 33% of hyperferritinemia cases reflect real hepatic iron overload.AimTo evaluate a non-invasive method for assessing mild iron overload in patients with NAFLD using 3T magnetic resonance imaging (MRI) relaxometry, serum hepcidin, and the expression of ferritin subunits.MethodsThis cross-sectional study assessed patients with biopsy-proven NAFLD. MRI relaxometry was performed using a 3T scanner in all patients, and the results were compared with iron content determined by liver biopsy. Ferritin, hepcidin, and ferritin subunits were assessed and classified according to ferritin levels and to siderosis identified by liver biopsy.ResultsA total of 67 patients with NAFLD were included in the study. MRI revealed mild iron overload in all patients (sensitivity, 73.5%; specificity, 70%). For mild (grade 1) siderosis, the transverse relaxation rate (R2*) threshold was 58.9 s?1 and the mean value was 72.5 s?1 (SD, 33.9), while for grades 2/3 it was 88.2 s?1 (SD, 31.9) (p < 0.001). The hepcidin threshold for siderosis was > 30.2 ng/mL (sensitivity, 87%; specificity, 82%). Ferritin H and ferritin L subunits were expressed similarly in patients with NAFLD, regardless of siderosis. There were no significant differences in laboratory test results between the groups, including glucose parameters and liver function tests.ConclusionsMRI relaxometry and serum hepcidin accurately assessed mild iron overload in patients with dysmetabolic iron overload syndrome. 相似文献
3.
Pikis Stylianos Mantziaris Georgios Islim Abdurrahman I. Peker Selcuk Samanci Yavuz Nabeel Ahmed M. Reda Wael A. Abdelkarim Khaled El-Shehaby Amr M. N. Tawadros Sameh R. Emad Reem M. Delabar Violaine Mathieu David Lee Cheng-chia Yang Huai-che Licsak Roman Hanuska Jaromir Alvarez Roberto Martinez Patel Dev N. Kondziolka Douglas Bernstein Kenneth Moreno Nuria Martinez Tripathi Manjul Speckter Herwin Albert Camilo Bowden Greg N. Benveniste Ronald J. Lunsford Dade L. Jenkinson Michael D. Sheehan Jason 《Journal of neuro-oncology》2022,157(1):121-128
Journal of Neuro-Oncology - The optimal treatment strategy of asymptomatic, convexity meningiomas, remains unclear. The purpose of this study was to define the safety and efficacy of stereotactic... 相似文献
4.
Singh Amita Sun Deyu Mor-Avi Victor Addetia Karima Patel Amit R. DeCara Jeanne M. Ward R. Parker Lang Roberto M. 《The international journal of cardiovascular imaging》2022,38(5):965-974
The International Journal of Cardiovascular Imaging - Echocardiographic evaluation of left ventricular diastolic function relies on a multi-pronged algorithm, which incorporates Doppler-based and... 相似文献
5.
Ruscitti Piero Di Cola Ilenia Berardicurti Onorina Conforti Alessandro Iacono Daniela Pantano Ilenia Rozza Gelsomina Rossi Silvia De Stefano Ludovico Balduzzi Silvia Vitale Antonio Caso Francesco Costa Luisa Prete Marcella Navarini Luca Atzeni Fabiola Guggino Giuliana Perosa Federico Cantarini Luca Frediani Bruno Montecucco Carlomaurizio Ciccia Francesco Giacomelli Roberto Cipriani Paola 《Clinical rheumatology》2022,41(11):3597-3597
Clinical Rheumatology - 相似文献
6.
Alterio Daniela La Rocca Eliana Volpe Stefania Camarda Anna Maria Casbarra Alessia Russell-Edu William Zerella Maria Alessia Orecchia Roberto Galimberti Viviana Veronesi Paolo Leonardi Maria Cristina Jereczek-Fossa Barbara Alicja 《Breast cancer research and treatment》2022,192(2):249-263
Breast Cancer Research and Treatment - To critically review available literature on hypofractionated (≥?3 Gy/fraction) proton therapy (PT) for breast cancer (BCa). A systematic... 相似文献
7.
Olivari Davide De Giorgio Daria Staszewsky Lidia Irene Fumagalli Francesca Boccardo Antonio Novelli Deborah Manfredi Martina Babini Giovanni Luciani Anita Ruggeri Laura Magliocca Aurora Zani Davide Danilo Masson Serge Belloli Angelo Pravettoni Davide Maiocchi Giuseppe Latini Roberto Ristagno Giuseppe 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2022,36(4):727-738
Cardiovascular Drugs and Therapy - Available animal models of acute heart failure (AHF) and their limitations are discussed herein. A novel and preclinically relevant porcine model of decompensated... 相似文献
8.
Yadav Siddhartha Sangaralingham Lindsey Payne Stephanie R. Giridhar Karthik V. Hieken Tina J. Boughey Judy C. Mutter Robert W. Hawse John R. Jimenez Rafael E. Freedman Rachel A. Khanani Sadia Couch Fergus J. Vachon Celine Shah Nilay Leon-Ferre Roberto A. Ruddy Kathryn J. 《Breast cancer research and treatment》2022,194(3):693-698
Breast Cancer Research and Treatment - To identify the practice patterns related to use of surveillance mammography in male breast cancer (MaBC) survivors. Using administrative claims data from... 相似文献
9.
Edwin Jabbari Shunsuke Koga Rebecca R Valentino Regina H Reynolds Raffaele Ferrari Manuela M X Tan James B Rowe Clifton L Dalgard Sonja W Scholz Dennis W Dickson Thomas T Warner Tamas Revesz Günter U Höglinger Owen A Ross Mina Ryten John Hardy Maryam Shoai Huw R Morris 《Lancet neurology》2021,20(2):107-116
10.
Anna Cay Magorzata A.
liwiska Magdalena Zikowska Kacper ukasiewicz Roberto Pagano Jakub M. Dzik Katarzyna Kalita Tytus Berna Michael G. Stewart K. Peter Giese Kasia Radwanska 《The Journal of neuroscience》2021,41(11):2329
Cognitive processes that require spatial information rely on synaptic plasticity in the dorsal CA1 area (dCA1) of the hippocampus. Since the function of the hippocampus is impaired in aged individuals, it remains unknown how aged animals make spatial choices. Here, we used IntelliCage to study behavioral processes that support spatial choices of aged female mice living in a group. As a proxy of training-induced synaptic plasticity, we analyzed the morphology of dendritic spines and the expression of a synaptic scaffold protein, PSD-95. We observed that spatial choice training in young adult mice induced correlated shrinkage of dendritic spines and downregulation of PSD-95 in dCA1. Moreover, long-term depletion of PSD-95 by shRNA in dCA1 limited correct choices to a reward corner, while reward preference was intact. In contrast, old mice used behavioral strategies characterized by an increased tendency for perseverative visits and social interactions. This strategy resulted in a robust preference for the reward corner during the spatial choice task. Moreover, training decreased the correlation between PSD-95 expression and the size of dendritic spines. Furthermore, PSD-95 depletion did not impair place choice or reward preference in old mice. Thus, our data indicate that while young mice require PSD-95-dependent synaptic plasticity in dCA1 to make correct spatial choices, old animals observe cage mates and stick to a preferred corner to seek the reward. This strategy is resistant to the depletion of PSD-95 in the CA1 area. Overall, our study demonstrates that aged mice combine alternative behavioral and molecular strategies to approach and consume rewards in a complex environment.SIGNIFICANCE STATEMENT It remains poorly understood how aging affects behavioral and molecular processes that support cognitive functions. It is, however, essential to understand these processes to develop therapeutic interventions that support successful cognitive aging. Our data indicate that while young mice require PSD-95-dependent synaptic plasticity in dCA1 to make correct spatial choices (i.e., choices that require spatial information), old animals observe cage mates and stick to a preferred corner to seek the reward. This strategy is resistant to the depletion of PSD-95 in the CA1 area. Overall, our study demonstrates that aged mice combine alternative behavioral and molecular strategies to approach and consume rewards in a complex environment. Second, the contribution of PSD-95-dependent synaptic functions in spatial choice changes with age. 相似文献