全文获取类型
收费全文 | 4802篇 |
免费 | 306篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 272篇 |
妇产科学 | 145篇 |
基础医学 | 573篇 |
口腔科学 | 237篇 |
临床医学 | 369篇 |
内科学 | 998篇 |
皮肤病学 | 77篇 |
神经病学 | 412篇 |
特种医学 | 120篇 |
外国民族医学 | 1篇 |
外科学 | 658篇 |
综合类 | 86篇 |
一般理论 | 1篇 |
预防医学 | 395篇 |
眼科学 | 109篇 |
药学 | 328篇 |
中国医学 | 27篇 |
肿瘤学 | 300篇 |
出版年
2023年 | 68篇 |
2022年 | 65篇 |
2021年 | 202篇 |
2020年 | 165篇 |
2019年 | 170篇 |
2018年 | 210篇 |
2017年 | 135篇 |
2016年 | 145篇 |
2015年 | 172篇 |
2014年 | 225篇 |
2013年 | 267篇 |
2012年 | 351篇 |
2011年 | 360篇 |
2010年 | 206篇 |
2009年 | 118篇 |
2008年 | 239篇 |
2007年 | 253篇 |
2006年 | 250篇 |
2005年 | 207篇 |
2004年 | 192篇 |
2003年 | 180篇 |
2002年 | 152篇 |
2001年 | 57篇 |
2000年 | 62篇 |
1999年 | 73篇 |
1998年 | 32篇 |
1997年 | 27篇 |
1996年 | 27篇 |
1995年 | 30篇 |
1994年 | 15篇 |
1993年 | 22篇 |
1992年 | 46篇 |
1991年 | 41篇 |
1990年 | 41篇 |
1989年 | 42篇 |
1988年 | 29篇 |
1987年 | 41篇 |
1986年 | 30篇 |
1985年 | 31篇 |
1984年 | 19篇 |
1983年 | 14篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1979年 | 11篇 |
1978年 | 10篇 |
1977年 | 9篇 |
1975年 | 10篇 |
1974年 | 9篇 |
1971年 | 11篇 |
排序方式: 共有5138条查询结果,搜索用时 31 毫秒
1.
2.
Nur Azuatul Akma Kamaludin Nur Azree Ferdaus Kamudin Shalimar Abdullah Jamari Sapuan 《中华创伤杂志(英文版)》2019,22(1):59-62
Simultaneous ipsilateral fractures involving radial head and distal end of radius are uncommon. We present our thoughts on which fracture should be addressed first. A 68-year-old lady sustained an ipsilateral fracture of the right radial head and distal end of radius following a fall. Clinically her right elbow was posteriorly dislocated and right wrist was deformed. Plain radiographs showed an intraarticular fracture of the distal end of radius and a comminution radial head fracture with a proximally migrated radius. Magnetic resonance imaging (MRI) showed no significant ligament injuries. We addressed her distal radius first with an anatomical locking plate followed by her radial head with a radial head replacement. Our rationale to treat the distal end radius: first was to obtain a correct alignment of Lister's tubercle and correct the distal radius height. Lister's tubercle was used to guide for the correct rotation of the radial head prosthesis. Correcting the distal end fracture radial height helped us with length selection of the radial head prosthesis and address the proximally migrated radial shaft and neck. Postoperative radiographs showed an acceptable reduction. The Cooney score was 75 at 3 months postoperatively, which was equivalent to a fair functional outcome. 相似文献
3.
4.
Raya Saab MD Anas Obeid MD Fatiha Gachi MD Houda Boudiaf MD Lilit Sargsyan MD Khulood Al-Saad MD Tamar Javakhadze MD Azim Mehrvar MD Sawsan Sati Abbas MD Yasir Saadoon Abed Al-Agele MD Salma Al-Haddad MD Mouroge Hashim Al Ani MD Suleiman Al-Sweedan MD Amani Al Kofide MD Wasil Jastaniah MD Nisreen Khalifa MD Elie Bechara MD Malek Baassiri MD Peter Noun MD Jamila El-Houdzi MD Mohammed Khattab MD Krishna Sagar Sharma MD Yasser Wali MD Naureen Mushtaq MD Aliya Batool MD Mahwish Faizan MD Muhammad Rafie Raza MD Mohammad Najajreh MD Mohammed Awad Mohammed Abdallah MD Ghada Sousan MD Khaled M. Ghanem MD Ulker Kocak MD Tezer Kutluk MD Hacı Ahmet Demir MD Hamoud Hodeish MD Samar Muwakkit MD Asim Belgaumi MD Abdul-Hakim Al-Rawas MD Sima Jeha MD 《Cancer》2020,126(18):4235-4245
5.
Differential involvement of glutathione S‐transferase mu 1 and multidrug resistance protein 1 in melanoma acquired resistance to vinca alkaloids 下载免费PDF全文
Chaker Attaoua Laure‐Anaïs Vincent Aida Abdel Jaoued Kamel Hadj‐Kaddour Qiang Baï John De Vos Laurence Vian Pierre Cuq 《Fundamental & clinical pharmacology》2015,29(1):62-71
On account of its extreme intrinsic resistance to apoptosis and of its strong ability to become chemoresistant after a primary response to drugs, malignant melanoma (MM) is still a therapeutic challenge. We previously showed that glutathione S‐transferase mu 1 (GSTM1) acts in synergy with multidrug resistance protein 1 (MRP1) to protect GSTM1‐transfected human CAL1 melanoma cells from toxic effects of vincristine (VCR). Herein, we investigated the role of these proteins in the acquired resistance of CAL1 cells to vinca alkaloids (VAs). Resistant lines were established by continuous exposure (>1 year) of parental CAL1‐wt cells to VCR, vindesine (VDS), or vinorelbine (VRB): CAL1R‐VCR, CAL1R‐VDS, CAL1R‐VRB, respectively. All resistant lines displayed more than 10‐fold increase in resistance to their selection VA, and specifically expressed GSTM1. Suggesting a direct interaction between this protein and VAs, each VA specifically decreased the GSTM1‐mediated glutathione conjugation activity in cell lysates. Curcumin (GSTM1 inhibitor), BSO (glutathione synthesis inhibitor), and MK571 (MRP1 inhibitor) considerably reversed the acquired resistance to VCR and VDS, but not to VRB. Microarray data analysis revealed similar gene expression patterns of CAL1R‐VCR and CAL1R‐VDS, and a distinct one for CAL1R‐VRB. These data suggest a differential involvement of GSTM1 and MRP1 in acquired resistance to VAs. A coordinated expression and activity of GSTM1 and MRP1 is required to protect CAL1 cells from VCR and VDS, while the simple expression of GSTM1 is sufficient, possibly by a direct drug/protein interaction, to confer resistance against VRB. 相似文献
6.
7.
Nur A. Hasan Talayeh Rezayat Peter J. Blatz Seon Young Choi Kimberly J. Griffitt Shah M. Rashed Anwar Huq Nicholas G. Conger Rita R. Colwell D. Jay Grimes 《Journal of clinical microbiology》2015,53(1):9-14
An occurrence of Vibrio cholerae non-O1/O139 gastroenteritis in the U.S. Gulf Coast is reported here. Genomic analysis revealed that the isolate lacked known virulence factors associated with the clinical outcome of a V. cholerae infection but did contain putative genomic islands and other accessory virulence factors. Many of these factors are widespread among environmental strains of V. cholerae, suggesting that there might be additional virulence factors in non-O1/O139 V. cholerae yet to be determined. Phylogenetic analysis revealed that the isolate belonged to a phyletic lineage of environmental V. cholerae isolates associated with sporadic cases of gastroenteritis in the Western Hemisphere, suggesting a need to monitor non-O1/O139 V. cholerae in the interest of public health. 相似文献
8.
9.
10.
Georgios Megas Michael Chrisofos Ioannis Anastasiou Aida Tsitlidou Theodosia Choreftaki Charalampos Deliveliotis 《Asian journal of andrology》2015,17(1):98-105
The objective of this study was to evaluate the expression of estrogen receptors (ER(α) and ER(β)) and androgen receptors (ARs) as prognostic factors for biochemical recurrence, disease progression and survival in patients with pT3N0M0 prostate cancer (PCa) in an urban Greek population. A total of 100 consecutive patients with pT3N0M0 PCa treated with radical prostatectomy participated in the study. The mean age and follow-up were 64.2 and 6 years, respectively. The HSCORE was used for semi-quantitative analysis of the immunoreactivity of the receptors. The prognostic value of the ER(α) and ER(β) and AR was assessed in terms of recurrence, progression, and survival. AR expression was not associated with any of the above parameters; however, both ERs correlated with the prognosis. A univariate Cox regression analysis showed that ER(α) positive staining was significantly associated with a greater hazard for all outcomes. Increased ER(β) staining was significantly associated with a lower hazard for all outcomes in the univariate analysis. When both ER HSCORES were used for the analysis, it was found that patients with high ER(α) or low ER(β) HSCORES compared with patients with negatively stained ER(α) and >1.7 hSCORE ER(β) had 6.03, 10.93, and 10.53 times greater hazard for biochemical disease recurrence, progression of disease and death, respectively. Multiple Cox proportional hazard analyses showed that the age, preoperative prostate specific antigen, Gleason score and ERs were independent predictors of all outcomes. ER expression is an important prognosticator after radical prostatectomy in patients with pT3N0M0 PCa. By contrast, AR expression has limited prognostic value. 相似文献