全文获取类型
收费全文 | 6302篇 |
免费 | 365篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 41篇 |
儿科学 | 97篇 |
妇产科学 | 42篇 |
基础医学 | 793篇 |
口腔科学 | 108篇 |
临床医学 | 440篇 |
内科学 | 1426篇 |
皮肤病学 | 179篇 |
神经病学 | 421篇 |
特种医学 | 278篇 |
外科学 | 1103篇 |
综合类 | 14篇 |
预防医学 | 201篇 |
眼科学 | 266篇 |
药学 | 434篇 |
中国医学 | 20篇 |
肿瘤学 | 837篇 |
出版年
2023年 | 39篇 |
2022年 | 32篇 |
2021年 | 109篇 |
2020年 | 60篇 |
2019年 | 110篇 |
2018年 | 133篇 |
2017年 | 98篇 |
2016年 | 121篇 |
2015年 | 151篇 |
2014年 | 201篇 |
2013年 | 235篇 |
2012年 | 382篇 |
2011年 | 393篇 |
2010年 | 238篇 |
2009年 | 198篇 |
2008年 | 367篇 |
2007年 | 409篇 |
2006年 | 374篇 |
2005年 | 359篇 |
2004年 | 307篇 |
2003年 | 288篇 |
2002年 | 265篇 |
2001年 | 167篇 |
2000年 | 170篇 |
1999年 | 140篇 |
1998年 | 71篇 |
1997年 | 52篇 |
1996年 | 49篇 |
1995年 | 40篇 |
1994年 | 40篇 |
1993年 | 37篇 |
1992年 | 133篇 |
1991年 | 110篇 |
1990年 | 87篇 |
1989年 | 78篇 |
1988年 | 101篇 |
1987年 | 72篇 |
1986年 | 57篇 |
1985年 | 52篇 |
1984年 | 38篇 |
1983年 | 39篇 |
1982年 | 19篇 |
1979年 | 31篇 |
1977年 | 18篇 |
1975年 | 22篇 |
1973年 | 18篇 |
1972年 | 20篇 |
1970年 | 18篇 |
1969年 | 17篇 |
1968年 | 20篇 |
排序方式: 共有6700条查询结果,搜索用时 31 毫秒
1.
2.
Daisuke Yamamoto Kou Kayamori Kei Sakamoto Maiko Tsuchiya Tohru Ikeda Hiroyuki Harada Tetsuya Yoda Tetsuro Watabe Miki Hara‐Yokoyama 《Cancer science》2020,111(2):700-712
Claudins are the major component of tight junctions, which form a primary barrier to paracellular diffusion and maintain cell polarity in normal epithelia and endothelia. In cancer cells, claudins play additional roles besides serving as components of the tight junctions, and participate in anoikis or invasion. Among the claudin family proteins, claudin‐1 has the most promising potential, both diagnostically and prognostically, in many types of cancers, including oral, gastric, liver, and colon cancers. However, conflicting results have been reported in relation to the degree of claudin‐1 expression and the prognosis, suggesting that the expression level of claudin‐1 alone is not sufficient to analyze the relationship between claudin‐1 and cancer progression. As endocytic trafficking of claudin‐1 has been reported in several epithelial cell types in vitro, we aimed to determine whether intracellular localization of claudin‐1 is the missing aspect between claudin‐1 and cancer. We investigated the expression of claudin‐1 in 83 tongue squamous cell carcinoma (TSCC) pathological specimens. Although the expression level of claudin‐1 based on immunohistochemistry was not associated with TSCC progression, within the high claudin‐1 expression group, the incidence of intracellular localization of claudin‐1 was correlated with cervical lymph node metastasis. In an in vitro experiment, claudin‐1 was constitutively internalized in TSCC‐derived cells. Motility of TSCC‐derived cells was increased by deficiency of claudin‐1, suggesting that the decrease in cell‐surface claudin‐1 promoted the cell migration. Therefore, intracellular localization of claudin‐1 at the invasion front may represent a promising diagnostic marker of TSCC. 相似文献
3.
Hirokazu Miki Shingen Nakamura Masahiro Oura Hirofumi Hamano Kenji Ikuta Naoto Okada Yasunobu Okamoto Kimiko Sogabe Mamiko Takahashi Masami Iwasa Kengo Udaka Takeshi Harada Kiyoe Kurahashi Shiro Fujii Sumiko Yoshida Kumiko Kagawa Itsuro Endo Ken-ichi Aihara Masahiro Abe 《British journal of haematology》2019,186(2):355-358
4.
Rika Yoshimatsu Takuji Yamagami Miki Nishimori Kenta Ogi Yoriko Murata Hitomi Iwasa Kenji Kajiwara Tomoaki Yamanishi Hiroki Minamiguchi Takashi Karashima Keiji Inoue 《Journal of vascular and interventional radiology : JVIR》2019,30(3):460-465
Purpose
To evaluate the influence of percutaneous cryoablation for renal cell carcinoma on function of the affected kidney.Materials and Methods
Between June 2016 and September 2017 at our institution, 12 inoperable patients underwent 15 cryoablation sessions for 17 small renal tumors. Of these, 9 patients who underwent 11 sessions of cryoablation were the focus of this study. For those patients, time-dependent changes in postoperative renal function were investigated by a retrospective review of clinical records. Evaluated were the estimated glomerular filtration rate (eGFR) and scintigraphy using 99m technetium-mercaptoacetyltriglycine (99mTc-MAG3) before and 1 week, 1–2 months, and more than 6 months after cryoablation.Results
Mean baseline eGFR was 76.88 ± 29.82 mL/min/1.73 m2 (mean ± standard deviation; range, 23.4–112.5). Mean eGFR 1 week, 1–2 months, and more than 6 months after cryoablation were 74.56 ± 26.68 mL/min/1.73 m2 (21.0–101.1), 69.5 ± 25.28 mL/min/1.73 m2 (24.1–105.6), and 75.08 ± 26.25 mL/min/1.73 m2 (29.0–107.3), respectively. Changes were statistically insignificant (P = .6044, P = .6699, and P = .9038, respectively). Regarding split renal function, the mean baseline contribution of the affected kidney determined by 99mTc-MAG3 was 47.27% ± 6.14 (38.8%–57.0%). Mean contributions of the affected kidney 1 week after, 1–2 months after, and more than 6 months after cryoablation were 44.40% ± 5.37 (38.3%–53.6%), 44.57% ± 6.52 (34.35%–55.0%), and 45.41% ± 7.77 (34.4%–56.5%), respectively. Differences from baseline were significant for the earliest 2 periods (P = .0473 and P = .0334, respectively) but not the later period (P = .2532).Conclusions
Results suggested that total renal function does not worsen after cryoablation; however, function of the affected kidney worsened after cryoablation but later partially recovered. 相似文献5.
6.
Manabu Fujimoto Jun Asai Yoshihide Asano Takayuki Ishii Yohei Iwata Tamihiro Kawakami Masanari Kodera Masatoshi Abe Masahiro Amano Ryuta Ikegami Taiki Isei Zenzo Isogai Takaaki Ito Yuji Inoue Ryokichi Irisawa Masaki Ohtsuka Yoichi Omoto Hiroshi Kato Takafumi Kadono Sakae Kaneko Hiroyuki Kanoh Masakazu Kawaguchi Ryuichi Kukino Takeshi Kono Monji Koga Keisuke Sakai Eiichi Sakurai Yasuko Sarayama Yoichi Shintani Miki Tanioka Hideaki Tanizaki Jun Tsujita Naotaka Doi Takeshi Nakanishi Akira Hashimoto Minoru Hasegawa Masahiro Hayashi Kuninori Hirosaki Hideki Fujita Hiroshi Fujiwara Takeo Maekawa Koma Matsuo Naoki Madokoro Sei-Ichiro Motegi Hiroshi Yatsushiro Osamu Yamasaki Yuichiro Yoshino Andres James LE Pavoux Takao Tachibana Hironobu Ihn Japanese Dermatological Association Guidelines 《The Journal of dermatology》2020,47(10):1071-1109
The Japanese Dermatological Association prepared guidelines focused on the treatment of skin ulcers associated with connective tissue disease/vasculitis practical in clinical settings of dermatological care. Skin ulcers associated with connective tissue diseases or vasculitis occur on the background of a wide variety of diseases including, typically, systemic sclerosis but also systemic lupus erythematosus (SLE), dermatomyositis, rheumatoid arthritis (RA), various vasculitides and antiphospholipid antibody syndrome (APS). Therefore, in preparing the present guidelines, we considered diagnostic/therapeutic approaches appropriate for each of these disorders to be necessary and developed algorithms and clinical questions for systemic sclerosis, SLE, dermatomyositis, RA, vasculitis and APS. 相似文献
7.
8.
9.
Panicker Jalesh N. Simeoni Sara Miki Yasuo Batla Amit Iodice Valeria Holton Janice L. Sakakibara Ryuji Warner Thomas T. 《Journal of neurology》2020,267(3):659-664
Journal of Neurology - Lower urinary tract (LUT) dysfunction presents early in multiple system atrophy (MSA), usually initially as urinary urgency, frequency and incontinence, and voiding... 相似文献
10.